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Q5Z859

- MPK4_ORYSJ

UniProt

Q5Z859 - MPK4_ORYSJ

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Protein
Mitogen-activated protein kinase 4
Gene
MPK4, MAP2, MSRMK3, Os06g0699400, LOC_Os06g48590, P0468G03.11
Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Activated by threonine and tyrosine phosphorylation By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei61 – 611ATP By similarity
Active sitei158 – 1581Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi38 – 469ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. MAP kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to hydrogen peroxide Source: EnsemblPlants/Gramene
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Stress response

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_205014. CREB phosphorylation through the activation of Ras.
REACT_214549. Signalling to ERK5.
REACT_215626. ERK2 activation.
REACT_221522. ERKs are inactivated.
REACT_221537. ERK1 activation.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitogen-activated protein kinase 4 (EC:2.7.11.24)
Short name:
MAP kinase 4
Alternative name(s):
Multiple stress-responsive MAP kinase 3
OsMAP2
OsMSRMK3
Gene namesi
Name:MPK4
Synonyms:MAP2, MSRMK3
Ordered Locus Names:Os06g0699400, LOC_Os06g48590
ORF Names:P0468G03.11
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 6

Organism-specific databases

GrameneiQ5Z859.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 369369Mitogen-activated protein kinase 4
PRO_0000239747Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei191 – 1911Phosphothreonine By similarity
Modified residuei193 – 1931Phosphotyrosine By similarity

Post-translational modificationi

Dually phosphorylated on Thr-191 and Tyr-193, which activates the enzyme By similarity.

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Expressed in leaves and panicles.1 Publication

Inductioni

By stresses, hormones, heavy metals, phosphatase inhibitors and infection with rice blast fungus (M.grisea). Down-regulated by drought, high/low temperature and UV-C.2 Publications

Structurei

3D structure databases

ProteinModelPortaliQ5Z859.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 319288Protein kinase
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi191 – 1933TXY

Domaini

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
KOiK04371.
OMAiMYPQAHP.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Z859-1 [UniParc]FASTAAdd to Basket

« Hide

MAMMVDPPNG MGNQGKHYYT MWQTLFEIDT KYVPIKPIGR GAYGIVCSSI    50
NRATNEKVAI KKINNVFDNR VDALRTLREL KLLRHLRHEN VIALKDIMMP 100
VHRRSFKDVY LVYELMDTDL HQIIKSSQPL SNDHCQYFLF QLLRGLKYLH 150
SAGILHRDLK PGNLLVNANC DLKICDFGLA RTNNTKGQFM TEYVVTRWYR 200
APELLLCCDN YGTSIDVWSV GCIFAELLGR KPIFPGTECL NQLKLIVNVL 250
GTMSEADIEF IDNPKARKYI KTLPYTPGIP LTSMYPQAHP LAIDLLQKML 300
VFDPSKRISV TEALEHPYMS PLYDPSANPP AQVPIDLDID ENLGVDMIRE 350
MMWQEMLHYH PEVVAGVNM 369
Length:369
Mass (Da):42,244
Last modified:November 23, 2004 - v1
Checksum:iD21EBE45865CE08B
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21A → V1 Publication
Sequence conflicti2 – 21A → V1 Publication
Sequence conflicti32 – 321Y → V in CAB61889. 1 Publication
Sequence conflicti331 – 3311A → V in CAB61889. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF216316 mRNA. Translation: AAG40580.1.
AJ512642 mRNA. Translation: CAD54741.1.
AJ251330 mRNA. Translation: CAB61889.1.
AP004278 Genomic DNA. Translation: BAD53997.1.
RefSeqiNP_001058471.1. NM_001065006.1.
UniGeneiOs.4602.

Genome annotation databases

EnsemblPlantsiOS06T0699400-01; OS06T0699400-01; OS06G0699400.
GeneIDi4341956.
KEGGiosa:4341956.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF216316 mRNA. Translation: AAG40580.1 .
AJ512642 mRNA. Translation: CAD54741.1 .
AJ251330 mRNA. Translation: CAB61889.1 .
AP004278 Genomic DNA. Translation: BAD53997.1 .
RefSeqi NP_001058471.1. NM_001065006.1.
UniGenei Os.4602.

3D structure databases

ProteinModelPortali Q5Z859.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS06T0699400-01 ; OS06T0699400-01 ; OS06G0699400 .
GeneIDi 4341956.
KEGGi osa:4341956.

Organism-specific databases

Gramenei Q5Z859.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
KOi K04371.
OMAi MYPQAHP.

Enzyme and pathway databases

Reactomei REACT_205014. CREB phosphorylation through the activation of Ras.
REACT_214549. Signalling to ERK5.
REACT_215626. ERK2 activation.
REACT_221522. ERKs are inactivated.
REACT_221537. ERK1 activation.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS01351. MAPK. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Two novel mitogen-activated protein signaling components, OsMEK1 and OsMAP1, are involved in a moderate low-temperature signaling pathway in rice."
    Wen J.-Q., Oono K., Imai R.
    Plant Physiol. 129:1880-1891(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Novel rice MAP kinases OsMSRMK3 and OsWJUMK1 involved in encountering diverse environmental stresses and developmental regulation."
    Agrawal G.K., Agrawal S.K., Shibato J., Iwahashi H., Rakwal R.
    Biochem. Biophys. Res. Commun. 300:775-783(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: cv. Nipponbare.
    Tissue: Leaf.
  3. "Molecular cloning and expression of a MAP kinase homologue from rice."
    Huang H.-J., Fu S.-F., Tai Y.-H., Huang D.-D., Kuo T.T.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  5. "Molecular analysis of the rice MAP kinase gene family in relation to Magnaporthe grisea infection."
    Reyna N.S., Yang Y.
    Mol. Plant Microbe Interact. 19:530-540(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, NOMENCLATURE.

Entry informationi

Entry nameiMPK4_ORYSJ
AccessioniPrimary (citable) accession number: Q5Z859
Secondary accession number(s): Q8H0P1, Q9FQM2, Q9SMA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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