Q5Z3Z2 (Q5Z3Z2_NOCFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA gyrase subunit A HAMAP MF_01897
EC=5.99.1.3 HAMAP MF_01897

Gene names

Name:	gyrA HAMAP MF_01897 EMBL BAD54849.1
Ordered Locus Names:	NFA_70

Organism

Nocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]

Taxonomic identifier

247156 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	836 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings By similarity. SAAS SAAS006691 HAMAP MF_01897
Catalytic activity	ATP-dependent breakage, passage and rejoining of double-stranded DNA. SAAS SAAS006691 HAMAP MF_01897
Subunit structure	Made up of two chains. The A chain is responsible for DNA breakage and rejoining; the B chain catalyzes ATP hydrolysis. The enzyme forms an A2B2 tetramer By similarity. HAMAP MF_01897
Subcellular location	Cytoplasm By similarity SAAS SAAS006691 HAMAP MF_01897.
Sequence similarities	Belongs to the topoisomerase GyrA/ParC subunit family. HAMAP MF_01897

Ontologies

Keywords
Cellular component	Cytoplasm SAAS SAAS006691 HAMAP MF_01897
Ligand	ATP-binding SAAS SAAS006691 HAMAP MF_01897 DNA-binding SAAS SAAS006691 HAMAP MF_01897 Nucleotide-binding
Molecular function	Isomerase Topoisomerase SAAS SAAS006691 HAMAP MF_01897
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA topological change Inferred from electronic annotation. Source: InterPro DNA-dependent DNA replication Inferred from electronic annotation. Source: HAMAP regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Cellular component	chromosome Inferred from electronic annotation. Source: InterPro cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA topoisomerase (ATP-hydrolyzing) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5Z3Z2 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 07EF1176559F0302	FASTA	836	92,357
	10 20 30 40 50 60 MTDITLPPES AGDRVEPVDI QQEMQNSYID YAMSVIVGRA LPEVRDGLKP VHRRILYAMY 70 80 90 100 110 120 DNGYRPDRGY VKSARPVSDT MGNYHPHGDS AIYDTLVRMA QPWAMRYPLV DGQGNFGSRG 130 140 150 160 170 180 NDGAAAMRYT ECRLTPLAME MLREIDHETV DFIPNYDGKT QEPVVLPSRV PNMLMNGSNG 190 200 210 220 230 240 IAVGMATNIP PHNLTELAEA IYWALDNHDA DEETTLAACM ERIKGPDFPT AGLIVGTQGI 250 260 270 280 290 300 HDAYTTGRGS IKMRGVVEIE EDNRGRTTIV ITELPYQVNT DNFINAIAEQ VKDGKIAGIA 310 320 330 340 350 360 DIHDESSDRV GLRIVVTVKR DAVAKVVLNN LYKHTQLQTS FGANMLSIVD GVPRTLRLDQ 370 380 390 400 410 420 MIRLYVNHQL DVIIRRTRYL LRKAEERAHI LRGLVKALDA LDEVIALIRR SANTDTARTG 430 440 450 460 470 480 LMELLDIDEI QATAILDMQL RRLSALERQK IIDDLARIEA EIADYKDILD KPERQRAIVR 490 500 510 520 530 540 DELAEIVEKY GDERRTQIVS ADGDVADEDL IAREDVVVTI TETGYAKRTK TDLYRSQKRG 550 560 570 580 590 600 GKGVQGAGLK QDDIVKHFFV TSTHDWLLFF TNKGRVYRAK AYELPEANRT ARGQHVANLL 610 620 630 640 650 660 AFQPDEKIAQ IIQIKTYEDA PYLVLATKNG LVKKSRLSDF DSNRSGGIVA VNLRDNDELV 670 680 690 700 710 720 GAVLCSADDD LLLVSAQGQS IRFSATDEAL RPMGRATSGV QGMRFNAEDE LLSLNVVRPG 730 740 750 760 770 780 TYLLVATSGG YAKRTAIEEY TAQGRGGKGV LTIQFDARRG TLVGALIVDD DDELYAITSG 790 800 810 820 830 GGVIRTAANQ VRKAGRQTKG VRLMNLGEGD TLLAIARNAD EPDAVDGGDD TGSSQQ

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006618 Genomic DNA. Translation: BAD54849.1.
RefSeq	YP_116213.1. NC_006361.1.
3D structure databases
ProteinModelPortal	Q5Z3Z2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3109625.
GenomeReviews	Gene locus NFA_70 in contig AP006618_GR.
KEGG	nfa:nfa70.
NMPDR	fig|247156.1.peg.94.
PATRIC	22729462. VBINocFar94200_0007.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG635183.
OMA	TGRGRIY.
ProtClustDB	PRK05560.
Family and domain databases
HAMAP	MF_01897. GyrA. [Tree]
InterPro	IPR011042. 6-blade_b-propeller_TolB-like. IPR005743. GyrA. IPR006691. GyrA/parC_pinwhl. IPR002205. Topo_IIA_A/C. IPR013758. Topo_IIA_A/C_ab. IPR013757. Topo_IIA_A_a. IPR013760. Topo_IIA_cen. [Graphical view]
Gene3D	G3DSA:2.120.10.30. 6-blade_b-propeller_TolB-like. 1 hit. G3DSA:3.90.199.10. Topo_IIA_A/C_ab. 1 hit. G3DSA:1.10.268.10. Topo_IIA_A_a. 1 hit.
KO	K02469.
Pfam	PF03989. DNA_gyraseA_C. 6 hits. PF00521. DNA_topoisoIV. 1 hit. [Graphical view]
SMART	SM00434. TOP4c. 1 hit. [Graphical view]
SUPFAM	SSF56719. Topo_IIA_cen. 1 hit.
TIGRFAMs	TIGR01063. GyrA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5Z3Z2_NOCFA

Accession

Primary (citable) accession number: Q5Z3Z2

Entry history

Integrated into UniProtKB/TrEMBL:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)