ID   Q5Z362_NOCFA            Unreviewed;      1145 AA.
AC   Q5Z362;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   27-MAR-2024, entry version 127.
DE   RecName: Full=Serine/threonine-protein kinase PknK {ECO:0000256|PIRNR:PIRNR000574};
DE            EC=2.7.11.1 {ECO:0000256|PIRNR:PIRNR000574};
DE   AltName: Full=Protein kinase K {ECO:0000256|PIRNR:PIRNR000574};
GN   OrderedLocusNames=NFA_2870 {ECO:0000313|EMBL:BAD55129.1};
OS   Nocardia farcinica (strain IFM 10152).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Nocardia.
OX   NCBI_TaxID=247156 {ECO:0000313|EMBL:BAD55129.1, ECO:0000313|Proteomes:UP000006820};
RN   [1] {ECO:0000313|EMBL:BAD55129.1, ECO:0000313|Proteomes:UP000006820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152 {ECO:0000313|EMBL:BAD55129.1,
RC   ECO:0000313|Proteomes:UP000006820};
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001433,
CC         ECO:0000256|PIRNR:PIRNR000574};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775,
CC         ECO:0000256|PIRNR:PIRNR000574};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
CC       {ECO:0000256|PIRNR:PIRNR000574}.
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DR   EMBL; AP006618; BAD55129.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5Z362; -.
DR   STRING; 247156.NFA_2870; -.
DR   KEGG; nfa:NFA_2870; -.
DR   eggNOG; COG0515; Bacteria.
DR   eggNOG; COG2909; Bacteria.
DR   HOGENOM; CLU_006325_2_0_11; -.
DR   Proteomes; UP000006820; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd14014; STKc_PknB_like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR016236; Ser/Thr_kinase_PknK_prd.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR43289; MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED; 1.
DR   PANTHER; PTHR43289:SF32; SERINE_THREONINE-PROTEIN KINASE PKAB; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   Pfam; PF17874; TPR_MalT; 1.
DR   PIRSF; PIRSF000574; Ser/Thr_PK_PknK_prd; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000574};
KW   Kinase {ECO:0000256|PIRNR:PIRNR000574, ECO:0000313|EMBL:BAD55129.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|PIRNR:PIRNR000574};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006820};
KW   Serine/threonine-protein kinase {ECO:0000256|PIRNR:PIRNR000574,
KW   ECO:0000313|EMBL:BAD55129.1}; Transferase {ECO:0000256|PIRNR:PIRNR000574}.
FT   DOMAIN          1..260
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          287..347
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..323
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..347
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         26
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ   SEQUENCE   1145 AA;  124494 MW;  39512B98DE5480C3 CRC64;
     MEIGRGGFGV VYRCLQTALE RVVAVKVLPP DMDAESRERF LREEQAMGRL SGHPNIVDIL
     QVDVTASGLP FIVMPYCTHG SLEQLIHEQG PLGWADTLRV GVKLAGAIES AHRAQILHRD
     VKPGNVLLSS YGEPQLTDFG IARIPGGFRT SSSMITGSPA FTAPEVLKGE EPTVRSDVYG
     LGATLFALLT GHAAFERQAG EKVVAQFLRI TTQPVPDLRE QDIPAPVAEA IERAMSPDPQ
     QRPESAFEFG EMLRAAQRAL GQLPDEMALL DTAVLLDDLG EVRATEPHPS IRTQFSTRAR
     PSVTARRSWP LTLRPNVSQH PPGATSTTPP PTAATKFRPP TPARAPVPRP RLLEVLRAGG
     RRRLALIHAP AGFGKSTVAA QWRAELTDQG VPVAWIGLDH DDDNEVWFLA HLLQAIHRVR
     PAIGAGLDQA LEERPADAVA FVISTLIDEV HAGGETIVVV IEDWHRITDP GAHRAMAALL
     DNGCHHLRFV VTSRDQSGLP VNSMRVHDEL VEIGSAQLRL TRAETGQILV ERNGFELTDK
     QVEQIHRVTD GWPAAVQLVS LALRGNPDPQ RLISALPEGG HGIREYLAEN VLDTLEPRML
     DFLTAISVTE RVNASLAAAL SEDSEAELLL AQAEQRELFL RRIEHDPEWY RMQPLFAEHL
     RARLERTDAA KLRALHRKAS RWYAEHQFLR KSVDHALAAT DLKLALDLVE GGGMDLIDGS
     RLATLLGTVS KLPVQQVTSR SKLLMAVARA NVNLQQSGAA RSALGKLTNM LPGGSGEDET
     NRQRCEAAVL AAADAVTRDQ TDGVLDQVAD CLDNPDDLPA WTVSTAANVV SYVRLCTFDF
     DGARQIQEWA QPYHEKSKDP LGTVFGLCAQ GAAAYEQLDI PGANDYFERA WEVAHSRAGP
     RSHGVRVASA MLGELKYRAG DLATADRLLD ESHQLVTRVG TVDFLLATFV TGARVKAVRG
     DLATAAARLE EGERIAREYE LPRLGAHVRA ERLRLGLPVE PATESGPGPG LRRATGVAAL
     IAEAEETAAV RAMLAARPSH TDDAPVRRAR ALYGRTTEQG RPRAELDTAL LLAETLAASG
     WVGEATAMLV PAAQVCARLG WPRPLLDAGP RVVAILRVLR GELHLSPENA DETRLPTHFL
     DEVLG
//