Q5Z2Z4 (Q5Z2Z4_NOCFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetyl-coenzyme A synthetase HAMAP MF_01123
EC=6.2.1.1 HAMAP MF_01123

Alternative name(s):
Acetate--CoA ligase HAMAP MF_01123
Acyl-activating enzyme HAMAP MF_01123

Gene names

Name:	acsA HAMAP MF_01123
Ordered Locus Names:	NFA_3550

Organism

Nocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]

Taxonomic identifier

247156 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	650 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. HAMAP MF_01123
Post-translational modification	Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity. HAMAP MF_01123
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family. HAMAP MF_01123

Ontologies

Keywords
Ligand	ATP-binding HAMAP MF_01123 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01123
PTM	Acetylation HAMAP MF_01123
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	520	1	By similarity HAMAP MF_01123
Amino acid modifications
	Modified residue	615	1	N6-acetyllysine By similarity HAMAP MF_01123

Sequences

	Sequence		Length	Mass (Da)
	Q5Z2Z4 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 4B672114570BD3F8	FASTA	650	71,958
	10 20 30 40 50 60 MTETTADHRE SYPPSPEFVA GANADGSLYE RAQADRLGFW AEQARRLYWH TPFTEVLDWS 70 80 90 100 110 120 QAPVARWFAD GRLNVAYNCL DRHVLDGHGD QPAILWEGEP GDTRTLTYAQ LLTEVSKTAN 130 140 150 160 170 180 YLTELGLNTG DRVAIYLPMI PEAIIAMLAC ARLGLPHSVV FAGFSPAALR QRVDDAAARL 190 200 210 220 230 240 IITSDGQYRR GTPTPLKTAV DEALTEPGHT VEHVLIVNRC NLDIPLTPGR DLWWHDTIAH 250 260 270 280 290 300 APTQHTAQPL PAEHPLFILY TSGTTGKPKG ILHTSGGYLT QAAYTHHYVF DHKPGHDIYW 310 320 330 340 350 360 CTADIGWVTG HSYIVYGPLA NRATQILYEG TPNTPDEHRH FHIIEKYGVT IYYTAPTLIR 370 380 390 400 410 420 TFMKWGRHIP DAHNLTSLRL LGSVGEPINP EAWRWYRHVI GRDTTPIVDT WWQTETGAIM 430 440 450 460 470 480 ISPLPGITHT KPGAAMTPLP GISAQVVDDD ANPVTPGETE ANGYLVLDQP WPAMLRGIWG 490 500 510 520 530 540 DPDRYRDTYW NRYHTHGWYF AGDGAKIDTD GALWVLGRVD DVMNVSGHRI STAEVESALV 550 560 570 580 590 600 AHPAVAEAAV VGATDPTTGQ GIVAFVITNT TTNPHTTPDQ LITDLKTQVA QEISPIARPR 610 620 630 640 650 DIHIVPELPK TRSGKIMRRL LRDIAEGRPL GDTSTLVDPT VFEAIRAEKA

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006618 Genomic DNA. Translation: BAD55197.1.
RefSeq	YP_116561.1. NC_006361.1.
3D structure databases
ProteinModelPortal	Q5Z2Z4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3107699.
GenomeReviews	Gene locus NFA_3550 in contig AP006618_GR.
KEGG	nfa:nfa3550.
NMPDR	fig|247156.1.peg.422.
PATRIC	22730188. VBINocFar94200_0360.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG547964.
OMA	PEAMEST.
ProtClustDB	PRK00174.
Family and domain databases
HAMAP	MF_01123. Ac_CoA_synth. [Tree]
InterPro	IPR011904. Ac_CoA_lig. IPR024597. Acyl-CoA_synth_DUF3448. IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
KO	K01895.
PANTHER	PTHR24095:SF42. PTHR24095:SF42. 1 hit.
Pfam	PF00501. AMP-binding. 1 hit. PF11930. DUF3448. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5Z2Z4_NOCFA

Accession

Primary (citable) accession number: Q5Z2Z4

Entry history

Integrated into UniProtKB/TrEMBL:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)