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Q5Z2U3

- PANC_NOCFA

UniProt

Q5Z2U3 - PANC_NOCFA

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Protein
Pantothenate synthetase
Gene
panC, NFA_4060
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Proton donor By similarity
Binding sitei75 – 751Beta-alanine By similarity
Binding sitei75 – 751Pantoate By similarity
Binding sitei167 – 1671Pantoate By similarity
Binding sitei190 – 1901ATP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 518ATP By similarity
Nucleotide bindingi161 – 1644ATP By similarity
Nucleotide bindingi198 – 2014ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-418-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetase (EC:6.3.2.1)
Short name:
PS
Alternative name(s):
Pantoate--beta-alanine ligase
Pantoate-activating enzyme
Gene namesi
Name:panC
Ordered Locus Names:NFA_4060
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Pantothenate synthetaseUniRule annotation
PRO_0000128250Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi247156.nfa4060.

Structurei

3D structure databases

ProteinModelPortaliQ5Z2U3.
SMRiQ5Z2U3. Positions 9-291.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0414.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5Z2U3-1 [UniParc]FASTAAdd to Basket

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MIDPTLRGAY RPGQLTVHHD PAVLGSVAKA LRGVGRTVAL VPTMGALHQG    50
HLQIVRQAKR TNQVVIVSIF VNPLQFGAGE DLDKYPRTLD ADVELLRAEG 100
VELVFAPNAE QMYPDGPRTT VHPGPLGAEL EGASRPTHFA GMLTVVAKLL 150
QIARPHQAFF GEKDYQQLTL IRQMVRDLNF DVRIVAVPTV RESDGLALSS 200
RNRYLDAAQR ETALALSAAL SAGAHAGGLG AEGVLAAARA VLDATPGLDL 250
DYLELRSSTL GPAPASGNAR LLVAAKVGTT RLIDNIAVTL GAPIDGHPNL 300
DSQPEPAGTD PALLPPAR 318
Length:318
Mass (Da):33,561
Last modified:November 23, 2004 - v1
Checksum:iF443D21E97FF5D68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD55248.1.
RefSeqiYP_116612.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD55248; BAD55248; NFA_4060.
GeneIDi3111359.
KEGGinfa:nfa4060.
PATRICi22730292. VBINocFar94200_0411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD55248.1 .
RefSeqi YP_116612.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5Z2U3.
SMRi Q5Z2U3. Positions 9-291.
ModBasei Search...

Protein-protein interaction databases

STRINGi 247156.nfa4060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD55248 ; BAD55248 ; NFA_4060 .
GeneIDi 3111359.
KEGGi nfa:nfa4060.
PATRICi 22730292. VBINocFar94200_0411.

Phylogenomic databases

eggNOGi COG0414.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci NFAR247156:GJ9T-418-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiPANC_NOCFA
AccessioniPrimary (citable) accession number: Q5Z2U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 23, 2004
Last modified: June 11, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity.

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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