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Q5Z2U3

- PANC_NOCFA

UniProt

Q5Z2U3 - PANC_NOCFA

Protein

Pantothenate synthetase

Gene

panC

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei51 – 511Proton donorUniRule annotation
    Binding sitei75 – 751Beta-alanineUniRule annotation
    Binding sitei75 – 751PantoateUniRule annotation
    Binding sitei167 – 1671PantoateUniRule annotation
    Binding sitei190 – 1901ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 518ATPUniRule annotation
    Nucleotide bindingi161 – 1644ATPUniRule annotation
    Nucleotide bindingi198 – 2014ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-418-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Gene namesi
    Name:panCUniRule annotation
    Ordered Locus Names:NFA_4060
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Pantothenate synthetasePRO_0000128250Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi247156.nfa4060.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5Z2U3.
    SMRiQ5Z2U3. Positions 9-291.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pantothenate synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0414.
    KOiK01918.
    OMAiPTHFAGM.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    InterProiIPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5Z2U3-1 [UniParc]FASTAAdd to Basket

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    MIDPTLRGAY RPGQLTVHHD PAVLGSVAKA LRGVGRTVAL VPTMGALHQG    50
    HLQIVRQAKR TNQVVIVSIF VNPLQFGAGE DLDKYPRTLD ADVELLRAEG 100
    VELVFAPNAE QMYPDGPRTT VHPGPLGAEL EGASRPTHFA GMLTVVAKLL 150
    QIARPHQAFF GEKDYQQLTL IRQMVRDLNF DVRIVAVPTV RESDGLALSS 200
    RNRYLDAAQR ETALALSAAL SAGAHAGGLG AEGVLAAARA VLDATPGLDL 250
    DYLELRSSTL GPAPASGNAR LLVAAKVGTT RLIDNIAVTL GAPIDGHPNL 300
    DSQPEPAGTD PALLPPAR 318
    Length:318
    Mass (Da):33,561
    Last modified:November 23, 2004 - v1
    Checksum:iF443D21E97FF5D68
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD55248.1.
    RefSeqiYP_116612.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD55248; BAD55248; NFA_4060.
    GeneIDi3111359.
    KEGGinfa:nfa4060.
    PATRICi22730292. VBINocFar94200_0411.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD55248.1 .
    RefSeqi YP_116612.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5Z2U3.
    SMRi Q5Z2U3. Positions 9-291.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa4060.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD55248 ; BAD55248 ; NFA_4060 .
    GeneIDi 3111359.
    KEGGi nfa:nfa4060.
    PATRICi 22730292. VBINocFar94200_0411.

    Phylogenomic databases

    eggNOGi COG0414.
    KOi K01918.
    OMAi PTHFAGM.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci NFAR247156:GJ9T-418-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    InterProi IPR004821. Cyt_trans-like.
    IPR003721. Pantoate_ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiPANC_NOCFA
    AccessioniPrimary (citable) accession number: Q5Z2U3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3