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Q5Z2U3

- PANC_NOCFA

UniProt

Q5Z2U3 - PANC_NOCFA

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Protein

Pantothenate synthetase

Gene

panC

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei51 – 511Proton donorUniRule annotation
Binding sitei75 – 751Beta-alanineUniRule annotation
Binding sitei75 – 751PantoateUniRule annotation
Binding sitei167 – 1671PantoateUniRule annotation
Binding sitei190 – 1901ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 518ATPUniRule annotation
Nucleotide bindingi161 – 1644ATPUniRule annotation
Nucleotide bindingi198 – 2014ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-418-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:NFA_4060
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Pantothenate synthetasePRO_0000128250Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi247156.nfa4060.

Structurei

3D structure databases

ProteinModelPortaliQ5Z2U3.
SMRiQ5Z2U3. Positions 9-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
KOiK01918.
OMAiPTHFAGM.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5Z2U3 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIDPTLRGAY RPGQLTVHHD PAVLGSVAKA LRGVGRTVAL VPTMGALHQG
60 70 80 90 100
HLQIVRQAKR TNQVVIVSIF VNPLQFGAGE DLDKYPRTLD ADVELLRAEG
110 120 130 140 150
VELVFAPNAE QMYPDGPRTT VHPGPLGAEL EGASRPTHFA GMLTVVAKLL
160 170 180 190 200
QIARPHQAFF GEKDYQQLTL IRQMVRDLNF DVRIVAVPTV RESDGLALSS
210 220 230 240 250
RNRYLDAAQR ETALALSAAL SAGAHAGGLG AEGVLAAARA VLDATPGLDL
260 270 280 290 300
DYLELRSSTL GPAPASGNAR LLVAAKVGTT RLIDNIAVTL GAPIDGHPNL
310
DSQPEPAGTD PALLPPAR
Length:318
Mass (Da):33,561
Last modified:November 23, 2004 - v1
Checksum:iF443D21E97FF5D68
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD55248.1.
RefSeqiYP_116612.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD55248; BAD55248; NFA_4060.
GeneIDi3111359.
KEGGinfa:nfa4060.
PATRICi22730292. VBINocFar94200_0411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD55248.1 .
RefSeqi YP_116612.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5Z2U3.
SMRi Q5Z2U3. Positions 9-291.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa4060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD55248 ; BAD55248 ; NFA_4060 .
GeneIDi 3111359.
KEGGi nfa:nfa4060.
PATRICi 22730292. VBINocFar94200_0411.

Phylogenomic databases

eggNOGi COG0414.
KOi K01918.
OMAi PTHFAGM.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci NFAR247156:GJ9T-418-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiPANC_NOCFA
AccessioniPrimary (citable) accession number: Q5Z2U3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3