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Protein

Acetaldehyde dehydrogenase 1

Gene

NFA_4660

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281Acyl-thioester intermediateUniRule annotation
Binding sitei278 – 2781NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NADUniRule annotation
Nucleotide bindingi159 – 1679NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Ordered Locus Names:NFA_4660
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
ProteomesiUP000006820 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Acetaldehyde dehydrogenase 1PRO_0000387695Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa4660.

Structurei

3D structure databases

ProteinModelPortaliQ5Z2N3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
KOiK04073.
OMAiQRSEWLE.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5Z2N3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNGTVTAAI VGSGNISTDL LYKLLRSQAI EPRWMIGIDP ESEGLKRARG
60 70 80 90 100
LGLETSHEGV DWLLAQSELP DMIFEATSAY VHRAAAPRYA EAGIRAVDLT
110 120 130 140 150
PAAVGPAVVP PVNLGANLDA PNVNMITCGG QATIPIVAAV SRVVPVPYAE
160 170 180 190 200
IVASVSSVSA GPGTRANIDE FTKTTSRGVE TIGGAQRGKA IIILNPAEPP
210 220 230 240 250
MIMRDTIFCA IPEDADTDAI ADSIHRMVAD IQQYVPGYRL LNEPQFDEPS
260 270 280 290 300
VVSGGLAKVS VFVEVEGAGD FLPPYAGNLD IMTAAATKVG EVIAGQITSA

RV
Length:302
Mass (Da):31,545
Last modified:November 23, 2004 - v1
Checksum:i60BBA3FF721EF00E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD55308.1.
RefSeqiWP_011206995.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD55308; BAD55308; NFA_4660.
KEGGinfa:nfa4660.
PATRICi22730416. VBINocFar94200_0473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD55308.1.
RefSeqiWP_011206995.1. NC_006361.1.

3D structure databases

ProteinModelPortaliQ5Z2N3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi247156.nfa4660.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD55308; BAD55308; NFA_4660.
KEGGinfa:nfa4660.
PATRICi22730416. VBINocFar94200_0473.

Phylogenomic databases

eggNOGiCOG4569.
KOiK04073.
OMAiQRSEWLE.
OrthoDBiEOG6H1PXH.

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-478-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiACDH1_NOCFA
AccessioniPrimary (citable) accession number: Q5Z2N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 23, 2004
Last modified: July 22, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.