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Q5Z2N3

- ACDH1_NOCFA

UniProt

Q5Z2N3 - ACDH1_NOCFA

Protein

Acetaldehyde dehydrogenase 1

Gene

NFA_4660

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei128 – 1281Acyl-thioester intermediateUniRule annotation
    Binding sitei278 – 2781NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 164NADUniRule annotation
    Nucleotide bindingi159 – 1679NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-478-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
    Gene namesi
    Ordered Locus Names:NFA_4660
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Acetaldehyde dehydrogenase 1PRO_0000387695Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi247156.nfa4660.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5Z2N3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    KOiK04073.
    OMAiDIQQYVP.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5Z2N3-1 [UniParc]FASTAAdd to Basket

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    MSNGTVTAAI VGSGNISTDL LYKLLRSQAI EPRWMIGIDP ESEGLKRARG    50
    LGLETSHEGV DWLLAQSELP DMIFEATSAY VHRAAAPRYA EAGIRAVDLT 100
    PAAVGPAVVP PVNLGANLDA PNVNMITCGG QATIPIVAAV SRVVPVPYAE 150
    IVASVSSVSA GPGTRANIDE FTKTTSRGVE TIGGAQRGKA IIILNPAEPP 200
    MIMRDTIFCA IPEDADTDAI ADSIHRMVAD IQQYVPGYRL LNEPQFDEPS 250
    VVSGGLAKVS VFVEVEGAGD FLPPYAGNLD IMTAAATKVG EVIAGQITSA 300
    RV 302
    Length:302
    Mass (Da):31,545
    Last modified:November 23, 2004 - v1
    Checksum:i60BBA3FF721EF00E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD55308.1.
    RefSeqiYP_116672.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD55308; BAD55308; NFA_4660.
    GeneIDi3106946.
    KEGGinfa:nfa4660.
    PATRICi22730416. VBINocFar94200_0473.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD55308.1 .
    RefSeqi YP_116672.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5Z2N3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa4660.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD55308 ; BAD55308 ; NFA_4660 .
    GeneIDi 3106946.
    KEGGi nfa:nfa4660.
    PATRICi 22730416. VBINocFar94200_0473.

    Phylogenomic databases

    eggNOGi COG4569.
    KOi K04073.
    OMAi DIQQYVP.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci NFAR247156:GJ9T-478-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiACDH1_NOCFA
    AccessioniPrimary (citable) accession number: Q5Z2N3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3