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Q5Z2N3

- ACDH1_NOCFA

UniProt

Q5Z2N3 - ACDH1_NOCFA

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Protein
Acetaldehyde dehydrogenase 1
Gene
NFA_4660
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281Acyl-thioester intermediate By similarity
Binding sitei278 – 2781NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NAD By similarity
Nucleotide bindingi159 – 1679NAD By similarity

GO - Molecular functioni

  1. NAD binding Source: UniProtKB-HAMAP
  2. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1
Gene namesi
Ordered Locus Names:NFA_4660
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Acetaldehyde dehydrogenase 1UniRule annotation
PRO_0000387695Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa4660.

Structurei

3D structure databases

ProteinModelPortaliQ5Z2N3.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
KOiK04073.
OMAiDIQQYVP.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5Z2N3-1 [UniParc]FASTAAdd to Basket

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MSNGTVTAAI VGSGNISTDL LYKLLRSQAI EPRWMIGIDP ESEGLKRARG    50
LGLETSHEGV DWLLAQSELP DMIFEATSAY VHRAAAPRYA EAGIRAVDLT 100
PAAVGPAVVP PVNLGANLDA PNVNMITCGG QATIPIVAAV SRVVPVPYAE 150
IVASVSSVSA GPGTRANIDE FTKTTSRGVE TIGGAQRGKA IIILNPAEPP 200
MIMRDTIFCA IPEDADTDAI ADSIHRMVAD IQQYVPGYRL LNEPQFDEPS 250
VVSGGLAKVS VFVEVEGAGD FLPPYAGNLD IMTAAATKVG EVIAGQITSA 300
RV 302
Length:302
Mass (Da):31,545
Last modified:November 23, 2004 - v1
Checksum:i60BBA3FF721EF00E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD55308.1.
RefSeqiYP_116672.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD55308; BAD55308; NFA_4660.
GeneIDi3106946.
KEGGinfa:nfa4660.
PATRICi22730416. VBINocFar94200_0473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD55308.1 .
RefSeqi YP_116672.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5Z2N3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa4660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD55308 ; BAD55308 ; NFA_4660 .
GeneIDi 3106946.
KEGGi nfa:nfa4660.
PATRICi 22730416. VBINocFar94200_0473.

Phylogenomic databases

eggNOGi COG4569.
KOi K04073.
OMAi DIQQYVP.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-478-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiACDH1_NOCFA
AccessioniPrimary (citable) accession number: Q5Z2N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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