Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5Z2N3

- ACDH1_NOCFA

UniProt

Q5Z2N3 - ACDH1_NOCFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Acetaldehyde dehydrogenase 1

Gene

NFA_4660

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei128 – 1281Acyl-thioester intermediateUniRule annotation
Binding sitei278 – 2781NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 164NADUniRule annotation
Nucleotide bindingi159 – 1679NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-478-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 1UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 1UniRule annotation
Gene namesi
Ordered Locus Names:NFA_4660
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Acetaldehyde dehydrogenase 1PRO_0000387695Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa4660.

Structurei

3D structure databases

ProteinModelPortaliQ5Z2N3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
KOiK04073.
OMAiDIQQYVP.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5Z2N3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNGTVTAAI VGSGNISTDL LYKLLRSQAI EPRWMIGIDP ESEGLKRARG
60 70 80 90 100
LGLETSHEGV DWLLAQSELP DMIFEATSAY VHRAAAPRYA EAGIRAVDLT
110 120 130 140 150
PAAVGPAVVP PVNLGANLDA PNVNMITCGG QATIPIVAAV SRVVPVPYAE
160 170 180 190 200
IVASVSSVSA GPGTRANIDE FTKTTSRGVE TIGGAQRGKA IIILNPAEPP
210 220 230 240 250
MIMRDTIFCA IPEDADTDAI ADSIHRMVAD IQQYVPGYRL LNEPQFDEPS
260 270 280 290 300
VVSGGLAKVS VFVEVEGAGD FLPPYAGNLD IMTAAATKVG EVIAGQITSA

RV
Length:302
Mass (Da):31,545
Last modified:November 23, 2004 - v1
Checksum:i60BBA3FF721EF00E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD55308.1.
RefSeqiWP_011206995.1. NC_006361.1.
YP_116672.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD55308; BAD55308; NFA_4660.
GeneIDi3106946.
KEGGinfa:nfa4660.
PATRICi22730416. VBINocFar94200_0473.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD55308.1 .
RefSeqi WP_011206995.1. NC_006361.1.
YP_116672.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5Z2N3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa4660.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD55308 ; BAD55308 ; NFA_4660 .
GeneIDi 3106946.
KEGGi nfa:nfa4660.
PATRICi 22730416. VBINocFar94200_0473.

Phylogenomic databases

eggNOGi COG4569.
KOi K04073.
OMAi DIQQYVP.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-478-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiACDH1_NOCFA
AccessioniPrimary (citable) accession number: Q5Z2N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3