Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38Desacetylmycothiol; via amide nitrogenUniRule annotation1
Binding sitei181DesacetylmycothiolUniRule annotation1
Binding sitei223DesacetylmycothiolUniRule annotation1
Binding sitei234DesacetylmycothiolUniRule annotation1
Binding sitei272Desacetylmycothiol; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciNFAR247156:G1G24-606-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:NFA_5990
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000006820 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004002851 – 303Mycothiol acetyltransferaseAdd BLAST303

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi247156.nfa5990

Structurei

3D structure databases

ProteinModelPortaliQ5Z297
SMRiQ5Z297
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 141N-acetyltransferase 1UniRule annotationAdd BLAST138
Domaini154 – 303N-acetyltransferase 2UniRule annotationAdd BLAST150

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni80 – 82Acetyl-CoA binding 1UniRule annotation3
Regioni238 – 240Acetyl-CoA binding 2UniRule annotation3
Regioni245 – 251Acetyl-CoA binding 2UniRule annotation7
Regioni277 – 282Acetyl-CoA binding 2UniRule annotation6

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV Bacteria
COG0456 LUCA
KOiK15520
OMAiAEPWFDP
OrthoDBiPOG091H09IL

Family and domain databases

HAMAPiMF_01698 MshD, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR000182 GNAT_dom
IPR017813 Mycothiol_AcTrfase
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 2 hits
PIRSFiPIRSF021524 MSH_acetyltransferase, 1 hit
SUPFAMiSSF55729 SSF55729, 1 hit
TIGRFAMsiTIGR03448 mycothiol_MshD, 1 hit
PROSITEiView protein in PROSITE
PS51186 GNAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q5Z297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDITVRWTQ RLDGETADAV RELLAAASAA DGVAPVSEQA VLSLGEPGAA
60 70 80 90 100
RHLLAEHDGE LAGYANLVPA HGDHPAMAEA AVAPARRGRG IGTALVREAL
110 120 130 140 150
AAGGADARVW AHGDRPAAKA VAARLGLRTA RELWQMRRSL ATPQLPELVV
160 170 180 190 200
PDGIVLRTYA GPADDAELLR VNNAAFDWHP EQGGWTQRDI AVRRAESWFD
210 220 230 240 250
PAGLFLATDT AAPDRVLGFH WTKVHADEQP PVGEVYVVGI DPAAQGRGLG
260 270 280 290 300
RLLTLAGLHH LRERGLGGVL LYTEADNTAA VNTYTKLGFA PAHVDVAYAA

NGA
Length:303
Mass (Da):31,936
Last modified:November 23, 2004 - v1
Checksum:iE4FF0633185ABC5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA Translation: BAD55444.1
RefSeqiWP_011207131.1, NC_006361.1

Genome annotation databases

EnsemblBacteriaiBAD55444; BAD55444; NFA_5990
KEGGinfa:NFA_5990

Similar proteinsi

Entry informationi

Entry nameiMSHD_NOCFA
AccessioniPrimary (citable) accession number: Q5Z297
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health