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Protein

Mycothiol acetyltransferase

Gene

mshD

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.UniRule annotation

Catalytic activityi

Desacetylmycothiol + acetyl-CoA = CoA + mycothiol.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381Desacetylmycothiol; via amide nitrogenUniRule annotation
Binding sitei181 – 1811DesacetylmycothiolUniRule annotation
Binding sitei223 – 2231DesacetylmycothiolUniRule annotation
Binding sitei234 – 2341DesacetylmycothiolUniRule annotation
Binding sitei272 – 2721Desacetylmycothiol; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-615-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Mycothiol acetyltransferaseUniRule annotation (EC:2.3.1.189UniRule annotation)
Short name:
MSH acetyltransferaseUniRule annotation
Alternative name(s):
Mycothiol synthaseUniRule annotation
Gene namesi
Name:mshDUniRule annotation
Ordered Locus Names:NFA_5990
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000006820 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Mycothiol acetyltransferasePRO_0000400285Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi247156.nfa5990.

Structurei

3D structure databases

ProteinModelPortaliQ5Z297.
SMRiQ5Z297. Positions 6-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 141138N-acetyltransferase 1UniRule annotationAdd
BLAST
Domaini154 – 303150N-acetyltransferase 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni80 – 823Acetyl-CoA binding 1UniRule annotation
Regioni238 – 2403Acetyl-CoA binding 2UniRule annotation
Regioni245 – 2517Acetyl-CoA binding 2UniRule annotation
Regioni277 – 2826Acetyl-CoA binding 2UniRule annotation

Sequence similaritiesi

Belongs to the acetyltransferase family. MshD subfamily.UniRule annotation
Contains 2 N-acetyltransferase domains.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
KOiK15520.
OMAiMLYVDES.
OrthoDBiEOG69D3BP.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Z297-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDITVRWTQ RLDGETADAV RELLAAASAA DGVAPVSEQA VLSLGEPGAA
60 70 80 90 100
RHLLAEHDGE LAGYANLVPA HGDHPAMAEA AVAPARRGRG IGTALVREAL
110 120 130 140 150
AAGGADARVW AHGDRPAAKA VAARLGLRTA RELWQMRRSL ATPQLPELVV
160 170 180 190 200
PDGIVLRTYA GPADDAELLR VNNAAFDWHP EQGGWTQRDI AVRRAESWFD
210 220 230 240 250
PAGLFLATDT AAPDRVLGFH WTKVHADEQP PVGEVYVVGI DPAAQGRGLG
260 270 280 290 300
RLLTLAGLHH LRERGLGGVL LYTEADNTAA VNTYTKLGFA PAHVDVAYAA

NGA
Length:303
Mass (Da):31,936
Last modified:November 23, 2004 - v1
Checksum:iE4FF0633185ABC5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD55444.1.
RefSeqiWP_011207131.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD55444; BAD55444; NFA_5990.
KEGGinfa:NFA_5990.
PATRICi22730700. VBINocFar94200_0615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD55444.1.
RefSeqiWP_011207131.1. NC_006361.1.

3D structure databases

ProteinModelPortaliQ5Z297.
SMRiQ5Z297. Positions 6-299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi247156.nfa5990.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD55444; BAD55444; NFA_5990.
KEGGinfa:NFA_5990.
PATRICi22730700. VBINocFar94200_0615.

Phylogenomic databases

eggNOGiENOG4108RTV. Bacteria.
COG0456. LUCA.
KOiK15520.
OMAiMLYVDES.
OrthoDBiEOG69D3BP.

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-615-MONOMER.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
HAMAPiMF_01698. MshD.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR017813. Mycothiol_AcTrfase.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 2 hits.
[Graphical view]
PIRSFiPIRSF021524. MSH_acetyltransferase. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR03448. mycothiol_MshD. 1 hit.
PROSITEiPS51186. GNAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiMSHD_NOCFA
AccessioniPrimary (citable) accession number: Q5Z297
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: November 23, 2004
Last modified: March 16, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.