Q5Z0Z9 (SYR_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arginine--tRNA ligase
EC=6.1.1.19

Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS

Gene names

Name:	argS
Ordered Locus Names:	NFA_10470

Organism

Nocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]

Taxonomic identifier

247156 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP MF_00123
Subunit structure	Monomer By similarity. HAMAP MF_00123
Subcellular location	Cytoplasm HAMAP MF_00123.
Sequence similarities	Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Aminoacyl-tRNA synthetase Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginyl-tRNA aminoacylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW arginine-tRNA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 552	552	Arginine--tRNA ligase HAMAP MF_00123		PRO_0000242058
Regions
	Motif	130 – 140	11	"HIGH" region HAMAP MF_00123

Sequences

	Sequence		Length	Mass (Da)
	Q5Z0Z9 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: FCE2A0FCFC6A59AA	FASTA	552	59,065
	10 20 30 40 50 60 MTPADLADLL RATAAKVLAE RGLDPAVLPD EVTVERPRNP EHGDYATNLA MKVAKKAGTN 70 80 90 100 110 120 PRDLAGWLAE ALGAADGITS AEVAGPGFLN IRLAAAAQGA VLEQVLAAGS GYGTADTLRG 130 140 150 160 170 180 TKINLEFVSA NPTGPIHLGG TRWASVGDAL GRILAAQGAD VTREYYFNDH GAQIDRFANS 190 200 210 220 230 240 LVAAATGQPT PDDGYAGAYI GEIAEQIVAE HPEAPTLPAD QRHELFRAEG VELMFAHIKR 250 260 270 280 290 300 TLHEFGTDFD VYFNESTLFA SGAVEQAVET LKASGDLYEK DGAWWIASSE YGDDQDRVVI 310 320 330 340 350 360 KSDGNAAYIA GDIAYFQNKR SRGFDLCIYM LGADHHGYIG RLKAAAAAFG DDPATVEVLI 370 380 390 400 410 420 GQMVNLVRDG QAVKMSKRAG TVVTLDDLVE AIGVDAARYA LVRWSVNSSV DIDLNLWTSQ 430 440 450 460 470 480 KNENPVYYVQ YAHARTASIG RNAAAFDYAS VTPDLSQLTA EEEGELIRTI GEYPRVVASA 490 500 510 520 530 540 ASLREPHRVA RYLEELAGAY HRFQTNSKLR VLPLGDDPVS PLNAARLVLV NATRQVLANG 550 LALLGVSAPE QM

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006618 Genomic DNA. Translation: BAD55892.1.
RefSeq	YP_117256.1. NC_006361.1.
3D structure databases
ProteinModelPortal	Q5Z0Z9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3109865.
GenomeReviews	Gene locus NFA_10470 in contig AP006618_GR.
KEGG	nfa:nfa10470.
NMPDR	fig|247156.1.peg.1082.
PATRIC	22731650. VBINocFar94200_1081.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG695395.
OMA	FDVYFHE.
ProtClustDB	PRK01611.
Enzyme and pathway databases
BioCyc	NFAR247156:NFA10470-MONOMER.
Family and domain databases
HAMAP	MF_00123. Arg_tRNA_synth. [Tree]
InterPro	IPR001412. aa-tRNA-synth_I_CS. IPR001278. Arg-tRNA-synth_Ia. IPR015945. Arg-tRNA-synth_Ia_core. IPR005148. Arg-tRNA-synth_N. IPR008909. DALR_anticod-bd. IPR014729. Rossmann-like_a/b/a_fold. IPR009080. tRNAsynth_1a_anticodon-bd. [Graphical view]
Gene3D	G3DSA:3.30.1360.70. Arg-tRNA-synth_Ic_N. 1 hit. G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K01887.
PANTHER	PTHR11956. Arg_tRNA-synt_1c. 1 hit.
Pfam	PF03485. Arg_tRNA_synt_N. 1 hit. PF05746. DALR_1. 1 hit. PF00750. tRNA-synt_1d. 1 hit. [Graphical view]
PRINTS	PR01038. TRNASYNTHARG.
SMART	SM01016. Arg_tRNA_synt_N. 1 hit. SM00836. DALR_1. 1 hit. [Graphical view]
SUPFAM	SSF55190. Arg-tRNA-synth_Ic_N. 1 hit. SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMs	TIGR00456. ArgS. 1 hit.
PROSITE	PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SYR_NOCFA

Accession

Primary (citable) accession number: Q5Z0Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program