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Q5Z0Z9 (SYR_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase
EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:NFA_10470
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia ›

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000242058

Regions

Motif130 – 14011"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q5Z0Z9 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: FCE2A0FCFC6A59AA

FASTA55259,065
        10         20         30         40         50         60 
MTPADLADLL RATAAKVLAE RGLDPAVLPD EVTVERPRNP EHGDYATNLA MKVAKKAGTN 

        70         80         90        100        110        120 
PRDLAGWLAE ALGAADGITS AEVAGPGFLN IRLAAAAQGA VLEQVLAAGS GYGTADTLRG 

       130        140        150        160        170        180 
TKINLEFVSA NPTGPIHLGG TRWASVGDAL GRILAAQGAD VTREYYFNDH GAQIDRFANS 

       190        200        210        220        230        240 
LVAAATGQPT PDDGYAGAYI GEIAEQIVAE HPEAPTLPAD QRHELFRAEG VELMFAHIKR 

       250        260        270        280        290        300 
TLHEFGTDFD VYFNESTLFA SGAVEQAVET LKASGDLYEK DGAWWIASSE YGDDQDRVVI 

       310        320        330        340        350        360 
KSDGNAAYIA GDIAYFQNKR SRGFDLCIYM LGADHHGYIG RLKAAAAAFG DDPATVEVLI 

       370        380        390        400        410        420 
GQMVNLVRDG QAVKMSKRAG TVVTLDDLVE AIGVDAARYA LVRWSVNSSV DIDLNLWTSQ 

       430        440        450        460        470        480 
KNENPVYYVQ YAHARTASIG RNAAAFDYAS VTPDLSQLTA EEEGELIRTI GEYPRVVASA 

       490        500        510        520        530        540 
ASLREPHRVA RYLEELAGAY HRFQTNSKLR VLPLGDDPVS PLNAARLVLV NATRQVLANG 

       550 
LALLGVSAPE QM

« Hide

References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006618 Genomic DNA. Translation: BAD55892.1.
RefSeqYP_117256.1. NC_006361.1.

3D structure databases

ProteinModelPortalQ5Z0Z9.
ModBaseSearch...

Protein-protein interaction databases

STRING247156.nfa10470.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD55892; BAD55892; NFA_10470.
GeneID3109865.
KEGGnfa:nfa10470.
PATRIC22731650. VBINocFar94200_1081.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMAHTSANPN.
ProtClustDBPRK01611.

Enzyme and pathway databases

BioCycNFAR247156:GJ9T-1072-MONOMER.

Family and domain databases

Gene3D3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase_Ia.
IPR015945. Arg-tRNA-synth_Ia_core.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF55190. Arg-tRNA-synth_Ic_N. 1 hit.
SSF47323. tRNAsyn_1a_bind. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_NOCFA
AccessionPrimary (citable) accession number: Q5Z0Z9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries

SIMILARITY comments

Index of protein domains and families

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