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Q5Z0K2

- COX1B_NOCFA

UniProt

Q5Z0K2 - COX1B_NOCFA

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Protein

Probable cytochrome c oxidase subunit 1-beta

Gene

ctaD2

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B per subunit.By similarity
Binds 2 heme groups per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Iron (heme A axial ligand)By similarity
Metal bindingi265 – 2651Copper BBy similarity
Metal bindingi269 – 2691Copper BBy similarity
Metal bindingi314 – 3141Copper BBy similarity
Metal bindingi315 – 3151Copper BBy similarity
Metal bindingi398 – 3981Iron (heme A3 axial ligand)By similarity
Metal bindingi400 – 4001Iron (heme A axial ligand)By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-1222-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1-beta (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-beta
Cytochrome c oxidase polypeptide I-beta
Gene namesi
Name:ctaD2
Ordered Locus Names:NFA_11940
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Probable cytochrome c oxidase subunit 1-betaPRO_0000183446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi247156.nfa11940.

Structurei

3D structure databases

ProteinModelPortaliQ5Z0K2.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence AnalysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence AnalysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence AnalysisAdd
BLAST
Transmembranei360 – 38021HelicalSequence AnalysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence AnalysisAdd
BLAST
Transmembranei477 – 49721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
KOiK02274.
OMAiILNIWIL.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Z0K2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTATPAQRRP ALPATRPYPA RHGPKGSYLR KMVTTTDPKD LGVLYLVSAT
60 70 80 90 100
GFFLIGGLLA LLMRGELARP GLQFLSAEQY NQLFTMHGTI MLLFYATPVV
110 120 130 140 150
FGFANAVLPL QIGAPDVAFP RLNAFSYWLY LFGATMATAG FLTPGGAADF
160 170 180 190 200
GWTAYTPLSL SEHSPGVGAD LWILGLAVSG LGTILGAVNM ITTVVCLRAP
210 220 230 240 250
GMTMFRMPIF TWNILITSIL VLLAFPILTA ALMALAYDRH LGGHIYDPAN
260 270 280 290 300
GGAILYQHLF WFFGHPEVYI IALPFFGIIS EVIPVFSRKP IFGYTALVYA
310 320 330 340 350
TLAIAALSMA VWAHHMYATG AVLLPFFSMM TFLIAVPTGV KFFNWIGTMW
360 370 380 390 400
KGQITFETPM LFAIGFIVTF LLGGLSGVIL ASPPLDWHVT DSYFVVAHFH
410 420 430 440 450
YVLFGTIVFA TFAGIYFWFP KLTGRFMDER LGRLHFWTTF LGFHLTFLVQ
460 470 480 490 500
HWLGNEGMPR RYADYLPSDG FTGLNTVSTI GSFLLGISMV TFVWNGFKSF
510 520 530 540 550
RYGEVVTVDD PWGAGNSLEW ATTCPPPRHN FYELPRIRSE RPAFELHYPH
560 570 580
MAERMRAEAH AGRRAGHGAG AELSVPSTVA TKDDDHTS
Length:588
Mass (Da):64,932
Last modified:November 23, 2004 - v1
Checksum:i21AD99945E88DF8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD56039.1.
RefSeqiYP_117403.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD56039; BAD56039; NFA_11940.
GeneIDi3106703.
KEGGinfa:nfa11940.
PATRICi22731964. VBINocFar94200_1235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD56039.1 .
RefSeqi YP_117403.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5Z0K2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa11940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD56039 ; BAD56039 ; NFA_11940 .
GeneIDi 3106703.
KEGGi nfa:nfa11940.
PATRICi 22731964. VBINocFar94200_1235.

Phylogenomic databases

eggNOGi COG0843.
KOi K02274.
OMAi ILNIWIL.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci NFAR247156:GJ9T-1222-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiCOX1B_NOCFA
AccessioniPrimary (citable) accession number: Q5Z0K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3