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Q5Z0K2

- COX1B_NOCFA

UniProt

Q5Z0K2 - COX1B_NOCFA

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Protein

Probable cytochrome c oxidase subunit 1-beta

Gene
ctaD2, NFA_11940
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Binds 1 copper B per subunit By similarity.
Binds 2 heme groups per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Iron (heme A axial ligand) By similarity
Metal bindingi265 – 2651Copper B By similarity
Metal bindingi269 – 2691Copper B By similarity
Metal bindingi314 – 3141Copper B By similarity
Metal bindingi315 – 3151Copper B By similarity
Metal bindingi398 – 3981Iron (heme A3 axial ligand) By similarity
Metal bindingi400 – 4001Iron (heme A axial ligand) By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-1222-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1-beta (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-beta
Cytochrome c oxidase polypeptide I-beta
Gene namesi
Name:ctaD2
Ordered Locus Names:NFA_11940
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321Helical; Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Transmembranei128 – 14821Helical; Reviewed predictionAdd
BLAST
Transmembranei171 – 19121Helical; Reviewed predictionAdd
BLAST
Transmembranei214 – 23421Helical; Reviewed predictionAdd
BLAST
Transmembranei259 – 27921Helical; Reviewed predictionAdd
BLAST
Transmembranei291 – 31121Helical; Reviewed predictionAdd
BLAST
Transmembranei320 – 34021Helical; Reviewed predictionAdd
BLAST
Transmembranei360 – 38021Helical; Reviewed predictionAdd
BLAST
Transmembranei399 – 41921Helical; Reviewed predictionAdd
BLAST
Transmembranei434 – 45421Helical; Reviewed predictionAdd
BLAST
Transmembranei477 – 49721Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Probable cytochrome c oxidase subunit 1-betaPRO_0000183446Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr) By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase By similarity.

Protein-protein interaction databases

STRINGi247156.nfa11940.

Structurei

3D structure databases

ProteinModelPortaliQ5Z0K2.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
KOiK02274.
OMAiILNIWIL.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Z0K2-1 [UniParc]FASTAAdd to Basket

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MTATPAQRRP ALPATRPYPA RHGPKGSYLR KMVTTTDPKD LGVLYLVSAT    50
GFFLIGGLLA LLMRGELARP GLQFLSAEQY NQLFTMHGTI MLLFYATPVV 100
FGFANAVLPL QIGAPDVAFP RLNAFSYWLY LFGATMATAG FLTPGGAADF 150
GWTAYTPLSL SEHSPGVGAD LWILGLAVSG LGTILGAVNM ITTVVCLRAP 200
GMTMFRMPIF TWNILITSIL VLLAFPILTA ALMALAYDRH LGGHIYDPAN 250
GGAILYQHLF WFFGHPEVYI IALPFFGIIS EVIPVFSRKP IFGYTALVYA 300
TLAIAALSMA VWAHHMYATG AVLLPFFSMM TFLIAVPTGV KFFNWIGTMW 350
KGQITFETPM LFAIGFIVTF LLGGLSGVIL ASPPLDWHVT DSYFVVAHFH 400
YVLFGTIVFA TFAGIYFWFP KLTGRFMDER LGRLHFWTTF LGFHLTFLVQ 450
HWLGNEGMPR RYADYLPSDG FTGLNTVSTI GSFLLGISMV TFVWNGFKSF 500
RYGEVVTVDD PWGAGNSLEW ATTCPPPRHN FYELPRIRSE RPAFELHYPH 550
MAERMRAEAH AGRRAGHGAG AELSVPSTVA TKDDDHTS 588
Length:588
Mass (Da):64,932
Last modified:November 23, 2004 - v1
Checksum:i21AD99945E88DF8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD56039.1.
RefSeqiYP_117403.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD56039; BAD56039; NFA_11940.
GeneIDi3106703.
KEGGinfa:nfa11940.
PATRICi22731964. VBINocFar94200_1235.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD56039.1 .
RefSeqi YP_117403.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5Z0K2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa11940.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD56039 ; BAD56039 ; NFA_11940 .
GeneIDi 3106703.
KEGGi nfa:nfa11940.
PATRICi 22731964. VBINocFar94200_1235.

Phylogenomic databases

eggNOGi COG0843.
KOi K02274.
OMAi ILNIWIL.
OrthoDBi EOG6B35XR.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci NFAR247156:GJ9T-1222-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiCOX1B_NOCFA
AccessioniPrimary (citable) accession number: Q5Z0K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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