Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5Z0K2 (COX1B_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 1-beta

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 1-beta
Cytochrome c oxidase polypeptide I-beta
Gene names
Name:ctaD2
Ordered Locus Names:NFA_11940
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia

Protein attributes

Sequence length588 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Binds 1 copper B per subunit By similarity.

Binds 2 heme groups per subunit By similarity.

Pathway

Energy metabolism; oxidative phosphorylation.

Subunit structure

Associates with subunits II, III and IV to form cytochrome c oxidase By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 588588Probable cytochrome c oxidase subunit 1-beta
PRO_0000183446

Regions

Transmembrane43 – 6321Helical; Potential
Transmembrane90 – 11021Helical; Potential
Transmembrane128 – 14821Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane214 – 23421Helical; Potential
Transmembrane259 – 27921Helical; Potential
Transmembrane291 – 31121Helical; Potential
Transmembrane320 – 34021Helical; Potential
Transmembrane360 – 38021Helical; Potential
Transmembrane399 – 41921Helical; Potential
Transmembrane434 – 45421Helical; Potential
Transmembrane477 – 49721Helical; Potential

Sites

Metal binding871Iron (heme A axial ligand) By similarity
Metal binding2651Copper B By similarity
Metal binding2691Copper B By similarity
Metal binding3141Copper B By similarity
Metal binding3151Copper B By similarity
Metal binding3981Iron (heme A3 axial ligand) By similarity
Metal binding4001Iron (heme A axial ligand) By similarity

Amino acid modifications

Cross-link265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5Z0K2 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 21AD99945E88DF8F

FASTA58864,932
        10         20         30         40         50         60 
MTATPAQRRP ALPATRPYPA RHGPKGSYLR KMVTTTDPKD LGVLYLVSAT GFFLIGGLLA 

        70         80         90        100        110        120 
LLMRGELARP GLQFLSAEQY NQLFTMHGTI MLLFYATPVV FGFANAVLPL QIGAPDVAFP 

       130        140        150        160        170        180 
RLNAFSYWLY LFGATMATAG FLTPGGAADF GWTAYTPLSL SEHSPGVGAD LWILGLAVSG 

       190        200        210        220        230        240 
LGTILGAVNM ITTVVCLRAP GMTMFRMPIF TWNILITSIL VLLAFPILTA ALMALAYDRH 

       250        260        270        280        290        300 
LGGHIYDPAN GGAILYQHLF WFFGHPEVYI IALPFFGIIS EVIPVFSRKP IFGYTALVYA 

       310        320        330        340        350        360 
TLAIAALSMA VWAHHMYATG AVLLPFFSMM TFLIAVPTGV KFFNWIGTMW KGQITFETPM 

       370        380        390        400        410        420 
LFAIGFIVTF LLGGLSGVIL ASPPLDWHVT DSYFVVAHFH YVLFGTIVFA TFAGIYFWFP 

       430        440        450        460        470        480 
KLTGRFMDER LGRLHFWTTF LGFHLTFLVQ HWLGNEGMPR RYADYLPSDG FTGLNTVSTI 

       490        500        510        520        530        540 
GSFLLGISMV TFVWNGFKSF RYGEVVTVDD PWGAGNSLEW ATTCPPPRHN FYELPRIRSE 

       550        560        570        580 
RPAFELHYPH MAERMRAEAH AGRRAGHGAG AELSVPSTVA TKDDDHTS 

« Hide

References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006618 Genomic DNA. Translation: BAD56039.1.
RefSeqYP_117403.1. NC_006361.1.

3D structure databases

ProteinModelPortalQ5Z0K2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING247156.nfa11940.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD56039; BAD56039; NFA_11940.
GeneID3106703.
KEGGnfa:nfa11940.
PATRIC22731964. VBINocFar94200_1235.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0843.
KOK02274.
OMAVNAIGFW.
OrthoDBEOG6B35XR.

Enzyme and pathway databases

BioCycNFAR247156:GJ9T-1222-MONOMER.
UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
TIGRFAMsTIGR02891. CtaD_CoxA. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1B_NOCFA
AccessionPrimary (citable) accession number: Q5Z0K2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways