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Protein

Probable cytochrome c oxidase subunit 1-beta

Gene

ctaD2

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+By similarityNote: Binds 1 copper B ion per subunit.By similarity
  • hemeBy similarityNote: Binds 2 heme groups per subunit.By similarity

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi87Iron (heme A axial ligand)By similarity1
Metal bindingi265Copper BBy similarity1
Metal bindingi269Copper BBy similarity1
Metal bindingi314Copper BBy similarity1
Metal bindingi315Copper BBy similarity1
Metal bindingi398Iron (heme A3 axial ligand)By similarity1
Metal bindingi400Iron (heme A axial ligand)By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Respiratory chain, Transport
LigandCopper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1-beta (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-beta
Cytochrome c oxidase polypeptide I-beta
Gene namesi
Name:ctaD2
Ordered Locus Names:NFA_11940
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000006820 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei90 – 110HelicalSequence analysisAdd BLAST21
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Transmembranei259 – 279HelicalSequence analysisAdd BLAST21
Transmembranei291 – 311HelicalSequence analysisAdd BLAST21
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Transmembranei360 – 380HelicalSequence analysisAdd BLAST21
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Transmembranei477 – 497HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001834461 – 588Probable cytochrome c oxidase subunit 1-betaAdd BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi247156.nfa11940

Structurei

3D structure databases

ProteinModelPortaliQ5Z0K2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ9 Bacteria
COG0843 LUCA
KOiK02274
OMAiPVDFQYH
OrthoDBiPOG091H042R

Family and domain databases

Gene3Di1.20.210.10, 1 hit
InterProiView protein in InterPro
IPR023616 Cyt_c_oxase-like_su1_dom
IPR036927 Cyt_c_oxase-like_su1_sf
IPR000883 Cyt_C_Oxase_1
IPR023615 Cyt_c_Oxase_su1_BS
IPR014241 Cyt_c_oxidase_su1_bac
PANTHERiPTHR10422 PTHR10422, 1 hit
PfamiView protein in Pfam
PF00115 COX1, 1 hit
PRINTSiPR01165 CYCOXIDASEI
SUPFAMiSSF81442 SSF81442, 1 hit
TIGRFAMsiTIGR02891 CtaD_CoxA, 1 hit
PROSITEiView protein in PROSITE
PS50855 COX1, 1 hit
PS00077 COX1_CUB, 1 hit

Sequencei

Sequence statusi: Complete.

Q5Z0K2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTATPAQRRP ALPATRPYPA RHGPKGSYLR KMVTTTDPKD LGVLYLVSAT
60 70 80 90 100
GFFLIGGLLA LLMRGELARP GLQFLSAEQY NQLFTMHGTI MLLFYATPVV
110 120 130 140 150
FGFANAVLPL QIGAPDVAFP RLNAFSYWLY LFGATMATAG FLTPGGAADF
160 170 180 190 200
GWTAYTPLSL SEHSPGVGAD LWILGLAVSG LGTILGAVNM ITTVVCLRAP
210 220 230 240 250
GMTMFRMPIF TWNILITSIL VLLAFPILTA ALMALAYDRH LGGHIYDPAN
260 270 280 290 300
GGAILYQHLF WFFGHPEVYI IALPFFGIIS EVIPVFSRKP IFGYTALVYA
310 320 330 340 350
TLAIAALSMA VWAHHMYATG AVLLPFFSMM TFLIAVPTGV KFFNWIGTMW
360 370 380 390 400
KGQITFETPM LFAIGFIVTF LLGGLSGVIL ASPPLDWHVT DSYFVVAHFH
410 420 430 440 450
YVLFGTIVFA TFAGIYFWFP KLTGRFMDER LGRLHFWTTF LGFHLTFLVQ
460 470 480 490 500
HWLGNEGMPR RYADYLPSDG FTGLNTVSTI GSFLLGISMV TFVWNGFKSF
510 520 530 540 550
RYGEVVTVDD PWGAGNSLEW ATTCPPPRHN FYELPRIRSE RPAFELHYPH
560 570 580
MAERMRAEAH AGRRAGHGAG AELSVPSTVA TKDDDHTS
Length:588
Mass (Da):64,932
Last modified:November 23, 2004 - v1
Checksum:i21AD99945E88DF8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA Translation: BAD56039.1
RefSeqiWP_011207724.1, NC_006361.1

Genome annotation databases

EnsemblBacteriaiBAD56039; BAD56039; NFA_11940
KEGGinfa:NFA_11940

Similar proteinsi

Entry informationi

Entry nameiCOX1B_NOCFA
AccessioniPrimary (citable) accession number: Q5Z0K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health