ID   HUTI_NOCFA              Reviewed;         392 AA.
AC   Q5Z0G2;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=Imidazolonepropionase;
DE            EC=3.5.2.7;
DE   AltName: Full=Imidazolone-5-propionate hydrolase;
GN   Name=hutI; OrderedLocusNames=NFA_12340;
OS   Nocardia farcinica.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=37329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- CATALYTIC ACTIVITY: (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-
CC       yl)propanoate + H(2)O = N-formimidoyl-L-glutamate + H(+).
CC   -!- COFACTOR: Binds 1 zinc or iron ion per subunit (By similarity).
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the hutI family.
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DR   EMBL; AP006618; BAD56079.1; -; Genomic_DNA.
DR   RefSeq; YP_117443.1; -.
DR   GeneID; 3109583; -.
DR   GenomeReviews; AP006618_GR; NFA_12340.
DR   KEGG; nfa:nfa12340; -.
DR   NMPDR; fig|247156.1.peg.1265; -.
DR   HOGENOM; Q5Z0G2; -.
DR   OMA; Q5Z0G2; MNMACTL.
DR   BioCyc; NFAR247156:NFA12340-MON; -.
DR   BRENDA; 3.5.2.7; 290697.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0050480; F:imidazolonepropionase activity; IEA:HAMAP.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate an...; IEA:InterPro.
DR   HAMAP; MF_00372; -; 1.
DR   InterPro; IPR006680; Amidohydro_1.
DR   InterPro; IPR005920; HutI.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   TIGRFAMs; TIGR01224; hutI; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Histidine metabolism; Hydrolase; Iron;
KW   Metal-binding; Zinc.
FT   CHAIN         1    392       Imidazolonepropionase.
FT                                /FTId=PRO_0000306475.
FT   METAL        70     70       Zinc or iron (By similarity).
FT   METAL        72     72       Zinc or iron (By similarity).
FT   METAL       227    227       Zinc or iron (By similarity).
FT   METAL       301    301       Zinc or iron (By similarity).
FT   BINDING      79     79       Substrate (By similarity).
FT   BINDING      92     92       Substrate (By similarity).
FT   BINDING     137    137       Substrate (By similarity).
FT   BINDING     164    164       Substrate (By similarity).
FT   BINDING     230    230       Substrate (By similarity).
SQ   SEQUENCE   392 AA;  41273 MW;  D3B6F77810B9482C CRC64;
     MPTTALTGIG QLVTNDPALG EGPLGLRRDA AIVFEDGVVA WVGDSAHVPA TDTAHDLDGR
     AVLPGFVESH SHLVFAGDRA EEFAARMSGR PYGAGGIRTT IEATRAATDE QLGANVRRLL
     DESLRAGSTT VECKSGYGQS VEHELRSVRV AGRYTDEVTL LAAHVPPPEY AGRVDDYVAM
     ACAEMIPRCA PHAKWIDVFC EQGAFDRDQA HAVLTAGIAH GLVPRVHGNQ LHRGPGVQLA
     VEVGAASVDH VTYIDDADIE ALAHSDTVAT LLPGADFCTR NSYPDARALL DAGVTVALGA
     DCNPGTSYTT SLPFCIALAV RELRMTPDEA VWAATAGGAR ALRRGDVGVL TPGARADALA
     LDAPSHLHLA YRPGVPLISR VWREGTLAYA TN
//