Q5Z077 (Q5Z077_NOCFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase HAMAP MF_00137
EC=6.3.2.6 HAMAP MF_00137

Alternative name(s):
SAICAR synthetase HAMAP MF_00137

Gene names

Name:	purC HAMAP MF_00137 EMBL BAD56164.1
Ordered Locus Names:	NFA_13190

Organism

Nocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]

Taxonomic identifier

247156 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate. HAMAP MF_00137 SAAS SAAS001636
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2. HAMAP MF_00137 SAAS SAAS001636
Sequence similarities	Belongs to the SAICAR synthetase family. HAMAP MF_00137 RuleBase RU004193

Ontologies

Keywords
Biological process	Purine biosynthesis HAMAP MF_00137 SAAS SAAS001636
Ligand	ATP-binding HAMAP MF_00137 SAAS SAAS001636 Nucleotide-binding
Molecular function	Ligase HAMAP MF_00137 SAAS SAAS001636
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5Z077 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: A1C7DEB8D78E7009	FASTA	296	32,601
	10 20 30 40 50 60 MRAVWFLRPG GRATTHGCGG STVKHVHAGK VRDLYEDGDT LLLVASDRVS VYDVVLPTPI 70 80 90 100 110 120 PGKGALLTQL SNWWFEFFAD IPNHIVSATD VPAEFAGRAV RVKPLRMVQV ECIARGYLTG 130 140 150 160 170 180 SGLKEYRASG TVSGVALPPG LRDGDKLPEP IFTPTSKASE GHDEPITFAD VVNQEGREVA 190 200 210 220 230 240 ELLRERTLEI YRRGAEHAAG NGVLIADTKV EFGWDGDVLT LGDEVLTSDS SRFWPADQWE 250 260 270 280 290 PGRPQPSFDK QFVRDWATST GWDKEPPGPE IPADIVEATR LKYQEAYELI TGREWS

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006618 Genomic DNA. Translation: BAD56164.1.
RefSeq	YP_117528.1. NC_006361.1.
3D structure databases
ProteinModelPortal	Q5Z077.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3111414.
GenomeReviews	Gene locus NFA_13190 in contig AP006618_GR.
KEGG	nfa:nfa13190.
NMPDR	fig|247156.1.peg.1350.
PATRIC	22732240. VBINocFar94200_1370.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG555040.
OMA	LTLMDEV.
ProtClustDB	PRK13961.
Family and domain databases
HAMAP	MF_00137. SAICAR_synth. [Tree]
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
KO	K01923.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5Z077_NOCFA

Accession

Primary (citable) accession number: Q5Z077

Entry history

Integrated into UniProtKB/TrEMBL:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)