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Q5YZD2 (Q5YZD2_NOCFA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pyruvate dehydrogenase E1 component PIRNR PIRNR000156
EC=1.2.4.1 PIRNR PIRNR000156
Gene names
Name:aceE EMBL BAD56459.1
Ordered Locus Names:NFA_16130
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length927 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity. PIRNR PIRNR000156

Catalytic activity

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2. PIRNR PIRNR000156

Cofactor

Thiamine pyrophosphate By similarity. PIRNR PIRNR000156

Sequences

Sequence LengthMass (Da)Tools
Q5YZD2 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 6367A9AFF5BB773F

FASTA927102,954
        10         20         30         40         50         60 
MASYLPDIDP EETGEWLESF DEMLDREGPQ RARYLMLRLL ERAGERRVSI PSLTSTDYVN 

        70         80         90        100        110        120 
TIPTENEPWF PGDEEVERRY RAWIRWNAAI MVHRAQRPGI GVGGHISTYA SSAALYEVGF 

       130        140        150        160        170        180 
NHFFRGKDHP GGGDQIFIQG HASPGIYARA FLEGRLTADQ LDGFRQEYSH GGLGHGLPSY 

       190        200        210        220        230        240 
PHPRLLNNFW EFPTVSMGLG PMNAIYQARF NHYLHDRGIK DTSDQHVWAF LGDGEMDEPE 

       250        260        270        280        290        300 
SRGLAHVAAM EGLDNLTFVV NCNLQRLDGP VRGNGKIIQE LEAFFRGAGW NVIKVIWGRE 

       310        320        330        340        350        360 
WDALLGADRD GALVNLMNST PDGDYQTYKA NDGAYVRDHF FGRDPRTKAL VQNMSDQEIW 

       370        380        390        400        410        420 
NLKRGGHDYR KVYAAYAAAM AHKGQPTVIL AKTIKGYTLG KHFEGRNATH QMKKLTLQDL 

       430        440        450        460        470        480 
KDFRDLQRIP ISDAELEKDP YLPPYYHPGM EAREIQYMLD RRRALGGFLP ERRAKAKPLQ 

       490        500        510        520        530        540 
LPGDEAYRSV RKGSGKQNVA TTMALVRLMK ELLRDKEIGK RIVPIIPDEA RTFGMDSWFP 

       550        560        570        580        590        600 
SLKIYNRNGQ LYTSVDAELM LAYKESTVGQ ILHEGINEAG STASFTAAGT SYATHGEPMI 

       610        620        630        640        650        660 
PLYIFYSMFG FQRTGDGLWA AADQLARGFV LGATAGRTTL TGEGLQHNDG HSLLLASTNP 

       670        680        690        700        710        720 
AVVTYDPAFA FEIAHIVRDG LRRMYGGGRP PAHQAVLPGT EPVERPDTDT FGGEDVFYYI 

       730        740        750        760        770        780 
TLYNEPYQQP AEPENLDVEG LLKGIYRYRA AGEGELRAQI LVSGVTVPDG LRAQALLAEE 

       790        800        810        820        830        840 
WGVQADVWSV TSWGELRKEA LAKEIAALRD PGADVGTPYI TEVLSAAGGP FVAATDWMRA 

       850        860        870        880        890        900 
VPDQVRQWVP GEFITLGTDG FGFSDTRPAA RRVFNVDAQS IAVAVLEGLA RTGKIDRSKA 

       910        920 
VEAARKYRIG DVDAAPKAAV SSDEDLA

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References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006618 Genomic DNA. Translation: BAD56459.1.
RefSeqYP_117823.1. NC_006361.1.

3D structure databases

ProteinModelPortalQ5YZD2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3109912.
GenomeReviewsGene locus NFA_16130 in contig AP006618_GR.
KEGGnfa:nfa16130.
NMPDRfig|247156.1.peg.1634.
PATRIC22732838. VBINocFar94200_1664.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG289271.
OMAFRQEKSH.
ProtClustDBPRK09405.

Family and domain databases

InterProIPR004660. 2-oxoA_DH_E1.
IPR009014. Transketo_C/Pyr-ferredox_oxred.
IPR015941. Transketolase-like_C.
IPR005474. Transketolase_N.
[Graphical view]
Gene3DG3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KOK00163.
PANTHERPTHR11624:SF37. PTHR11624:SF37. 1 hit.
PfamPF00456. Transketolase_N. 1 hit.
[Graphical view]
PIRSFPIRSF000156. Pyruvate_dh_E1. 1 hit.
SUPFAMSSF52922. Transketo_C_like. 1 hit.
TIGRFAMsTIGR00759. AceE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ5YZD2_NOCFA
AccessionPrimary (citable) accession number: Q5YZD2
Entry history
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info