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Protein

Glutamate-ammonia-ligase adenylyltransferase

Gene

glnE

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Adenylation and deadenylation of glutamate--ammonia ligase.UniRule annotation

Catalytic activityi

ATP + [L-glutamate:ammonia ligase (ADP-forming)]-L-tyrosine = diphosphate + [L-glutamate:ammonia ligase (ADP-forming)]-O(4)-(5'-adenylyl)-L-tyrosine.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-1699-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-ammonia-ligase adenylyltransferaseUniRule annotation (EC:2.7.7.42UniRule annotation)
Alternative name(s):
Glutamine-synthetase adenylyltransferase
Short name:
ATaseUniRule annotation
[Glutamate--ammonia-ligase] adenylyltransferaseUniRule annotation
Gene namesi
Name:glnEUniRule annotation
Ordered Locus Names:NFA_16610
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000006820 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10041004Glutamate-ammonia-ligase adenylyltransferasePRO_0000209261Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa16610.

Structurei

3D structure databases

ProteinModelPortaliQ5YZ84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni158 – 350193GlnE 1Add
BLAST
Regioni653 – 861209GlnE 2Add
BLAST

Sequence similaritiesi

Belongs to the GlnE family.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105CE6. Bacteria.
COG1391. LUCA.
KOiK00982.
OMAiEFMVQYA.
OrthoDBiPOG091H0675.

Family and domain databases

HAMAPiMF_00802. GlnE. 1 hit.
InterProiIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YZ84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRPPSARSA VPGVGRLGLL DPTAAASLRE LGWDNVESIP VLWALSRAPD
60 70 80 90 100
ADLALNTLMR LREALGSDWQ RLDSAIRTDT SLRGRLFALL GSSTALGDHL
110 120 130 140 150
VAEPAAWEVL RRGDLPDRDE LLADLLAAVQ ATPEAGPHAG PMLFRAGIAG
160 170 180 190 200
PEAVALLRCR YRDQLMLLAA LDLAATVENE PVLPYRVVGR HLTDLADAAL
210 220 230 240 250
TAALAVAVAR VCKDQPCPVR LAVIAMGKCG ARELNYVSDV DVVFVAEPAD
260 270 280 290 300
ATATRLAAEM MSVGSQAFFE VDAALRPEGK QGALVRTLDS HLTYYKRWAR
310 320 330 340 350
TWEFQALLKN RPMTGDLELG REYRDAVMPM VWTASERPDF VPEVQGMRRR
360 370 380 390 400
VEDLVPAELR ERELKLGRGS LRDVEFAVQL LQLVHGRVDE NLHVASTVDA
410 420 430 440 450
LSALAAGGYV GRDDAANLTA SYEFLRLLEH RLQLQRLKRT HTLPADDDEE
460 470 480 490 500
GMRWLARAAH IRPDGRQDAM GVLRSEIRRN AVRVRRLHAK LFYRPLLEAV
510 520 530 540 550
VRMDPDALRL SPDAAVRQLA ALGYAAPENA FGHLKALTGG VSRKGRIQAL
560 570 580 590 600
LLPTLLEWLG ETPNPDAGLL AYRRVSEALD EQTWFLRELR DEGAVAQRLM
610 620 630 640 650
IVLGSSEFLP DLLINAPETI RMFADGPHGP LLLGPQPEEV ARGILTAAAR
660 670 680 690 700
YDDPNRAVAA ARSLRRHELA RVASADLLGM LEVPQVCRAL SSVWVAVLDA
710 720 730 740 750
ALAAVIRAGE AESGEPAPAA FAVIGMGRLG GMELGYGSDA DVLFVCEPRP
760 770 780 790 800
GVDETKAVKW ANTVAERVQR LLGAPSTDPP LHVDAGLRPE GRSGALVRTL
810 820 830 840 850
SAYQAYYGQW AQSWEVQALL RAHQVAGDQE LGVRFLHAVD KVRYPAGGVS
860 870 880 890 900
EDAVREIRRI KARVDSERLP RGADPATHTK LGRGGLADIE WTVQLLQLRH
910 920 930 940 950
AHEVESLHNT ATLETLAAIE KAELLAAEDV ALLRDSWLLA TKARNALVLV
960 970 980 990 1000
RGKPSDQLPG PGRLLSAVAT VAGWPNNDGG SEFLDHYLRI TRRARAVVER

VFGS
Length:1,004
Mass (Da):109,461
Last modified:November 23, 2004 - v1
Checksum:i3F296121C8A8F601
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD56507.1.
RefSeqiWP_011208192.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD56507; BAD56507; NFA_16610.
KEGGinfa:NFA_16610.
PATRICi22732930. VBINocFar94200_1710.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD56507.1.
RefSeqiWP_011208192.1. NC_006361.1.

3D structure databases

ProteinModelPortaliQ5YZ84.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi247156.nfa16610.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD56507; BAD56507; NFA_16610.
KEGGinfa:NFA_16610.
PATRICi22732930. VBINocFar94200_1710.

Phylogenomic databases

eggNOGiENOG4105CE6. Bacteria.
COG1391. LUCA.
KOiK00982.
OMAiEFMVQYA.
OrthoDBiPOG091H0675.

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-1699-MONOMER.

Family and domain databases

HAMAPiMF_00802. GlnE. 1 hit.
InterProiIPR023057. GlnE.
IPR005190. GlnE_rpt_dom.
IPR013546. PII_UdlTrfase/GS_AdlTrfase.
[Graphical view]
PfamiPF08335. GlnD_UR_UTase. 2 hits.
PF03710. GlnE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLNE_NOCFA
AccessioniPrimary (citable) accession number: Q5YZ84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: September 7, 2016
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.