Q5YZ45 (Q5YZ45_NOCFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase HAMAP-Rule MF_00230
Short name=NN:DBI PRT HAMAP-Rule MF_00230
EC=2.4.2.21 HAMAP-Rule MF_00230

Alternative name(s):
N(1)-alpha-phosphoribosyltransferase HAMAP-Rule MF_00230

Gene names

Name:	cobT HAMAP-Rule MF_00230 EMBL BAD56546.1
Ordered Locus Names:	NFA_17000 EMBL BAD56546.1

Organism

Nocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP] EMBL BAD56546.1

Taxonomic identifier

247156 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia › Nocardia farcinica

Protein attributes

Sequence length	359 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB) By similarity. HAMAP-Rule MF_00230 SAAS SAAS017846
Catalytic activity	Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate. HAMAP-Rule MF_00230 SAAS SAAS017846
Pathway	Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2. HAMAP-Rule MF_00230 SAAS SAAS017846
Sequence similarities	Belongs to the CobT family. HAMAP-Rule MF_00230

Ontologies

Keywords
Biological process	Cobalamin biosynthesis HAMAP-Rule MF_00230 SAAS SAAS017846
Molecular function	Glycosyltransferase HAMAP-Rule MF_00230 SAAS SAAS017846 EMBL BAD56546.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cobalamin biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW nucleoside biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	cobalamin-transporting ATPase activity Inferred from electronic annotation. Source: HAMAP nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	314	1	Proton acceptor By similarity HAMAP-Rule MF_00230

Sequences

	Sequence		Length	Mass (Da)
	Q5YZ45 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 929AF2C6C96BADA9	FASTA	359	36,925
	10 20 30 40 50 60 MTHGFGPVAP PDARIRAEAE QRQARLTKPA GSLGRLERLG NWVAACQGVC PPRQFERARV 70 80 90 100 110 120 VVFAGDHGVA AHGVSAYPSE VTAQMVANFL AGGAAVNALA RVADATVRVV DIAVDADTDP 130 140 150 160 170 180 AVSGHKVRRS SGRIDREDAL SGEEVEAALA AGRAIADEEI DAGADLLIAG DMGIGNTTPA 190 200 210 220 230 240 TVLIATLTDT EPVAAVGRGT GVDDAGWIRK VAAIRDAMRR ARPVHKDPVD LLRVAASADI 250 260 270 280 290 300 AATAGFLAQA AVRRTPVLLD GVVVTAAALV AEDLAAGASA WWLAGHRSTE PAHALALRQL 310 320 330 340 350 RLDPLIDMEM RLGEGSGALT ALPILRAAVA ALAEMATFDE AGVSTAAPTA AESALNLRK

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152 EMBL BAD56546.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006618 Genomic DNA. Translation: BAD56546.1.
RefSeq	YP_117910.1. NC_006361.1.
3D structure databases
ProteinModelPortal	Q5YZ45.
ModBase	Search...
Protein-protein interaction databases
STRING	247156.nfa17000.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD56546; BAD56546; NFA_17000.
GeneID	3109787.
KEGG	nfa:nfa17000.
PATRIC	22733010. VBINocFar94200_1750.
Organism-specific databases
CMR	Search...
Phylogenomic databases
KO	K00768.
OMA	FICSVAA.
ProtClustDB	PRK00105.
Enzyme and pathway databases
BioCyc	NFAR247156:GJ9T-1738-MONOMER.
UniPathway	UPA00061; UER00516.
Family and domain databases
Gene3D	1.10.1610.10. 1 hit.
HAMAP	MF_00230. CobT.
InterPro	IPR003200. Nict_dMeBzImd_PRibTrfase-like. IPR023195. Nict_dMeBzImd_PRibTrfase_N. IPR017846. Nict_dMeBzImd_PRibTrfase_pro. [Graphical view]
Pfam	PF02277. DBI_PRT. 1 hit. [Graphical view]
SUPFAM	SSF52733. NN:DBI_PRT. 1 hit.
TIGRFAMs	TIGR03160. cobT_DBIPRT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q5YZ45_NOCFA

Accession

Primary (citable) accession number: Q5YZ45

Entry history

Integrated into UniProtKB/TrEMBL:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)