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Q5YZ37 (COX2_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene names
Name:ctaC
Ordered Locus Names:NFA_17080
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A By similarity.

Heme group By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 375375Probable cytochrome c oxidase subunit 2
PRO_0000183718

Regions

Transmembrane36 – 5621Helical; Potential
Transmembrane80 – 10021Helical; Potential
Transmembrane122 – 14221Helical; Potential

Sites

Metal binding2641Copper A Potential
Metal binding3051Copper A Potential
Metal binding3091Copper A Potential
Metal binding3131Copper A Potential

Sequences

Sequence LengthMass (Da)Tools
Q5YZ37 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 51FE78E89A462104

FASTA37541,976
        10         20         30         40         50         60 
MCGDQEGVSV AHKASEEIGA RPVRGRQGRI LRRAGLAVSL GITAMLVSGC SIDNVWLRFG 

        70         80         90        100        110        120 
WPSGVTPQAT RMRELWTWSI IAALAMGVLV WGLTFWTVVF HRKKKDSPEF PRQTGYNVPL 

       130        140        150        160        170        180 
ELTYTAIPFV IIAVLFYFTV VVQNYVHEKV ADPDVTVDVT AFQWNWKFGY REVDFKDGGY 

       190        200        210        220        230        240 
QFNGIDTARE EAAQAQLKEY EERVDTEHGH PQPGPVHGKP ENDILSYLHY DTVETVGTST 

       250        260        270        280        290        300 
EIPVLVLPTG KVIEFQLAAA DVIHAFWVPE FLFKRDVMPN PKENHSDNVF QITEIEKEGA 

       310        320        330        340        350        360 
FVGRCAEMCG TYHSMMNFEV RAVSPEKFTR YLDERRAGKT NAEALAAIGE SPVATSTRPF 

       370 
NTDRTVKSAA APEAE 

« Hide

References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006618 Genomic DNA. Translation: BAD56554.1.
RefSeqYP_117918.1. NC_006361.1.

3D structure databases

ProteinModelPortalQ5YZ37.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING247156.nfa17080.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD56554; BAD56554; NFA_17080.
GeneID3107212.
KEGGnfa:nfa17080.
PATRIC22733026. VBINocFar94200_1758.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1622.
KOK02275.
OMAMNFEVRA.
OrthoDBEOG68SVXT.
ProtClustDBCLSK2765886.

Enzyme and pathway databases

BioCycNFAR247156:GJ9T-1746-MONOMER.

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_NOCFA
AccessionPrimary (citable) accession number: Q5YZ37
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families