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Q5YZ37

- COX2_NOCFA

UniProt

Q5YZ37 - COX2_NOCFA

Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Copper A.By similarity
    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi264 – 2641Copper ASequence Analysis
    Metal bindingi305 – 3051Copper ASequence Analysis
    Metal bindingi309 – 3091Copper ASequence Analysis
    Metal bindingi313 – 3131Copper ASequence Analysis

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. electron transport chain Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-1746-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 2
    Cytochrome c oxidase polypeptide II
    Gene namesi
    Name:ctaC
    Ordered Locus Names:NFA_17080
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 375375Probable cytochrome c oxidase subunit 2PRO_0000183718Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi247156.nfa17080.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5YZ37.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei36 – 5621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei122 – 14221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1622.
    KOiK02275.
    OMAiMRELWTW.
    OrthoDBiEOG68SVXT.

    Family and domain databases

    Gene3Di1.10.287.90. 1 hit.
    2.60.40.420. 2 hits.
    InterProiIPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view]
    PfamiPF00116. COX2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    PROSITEiPS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5YZ37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGDQEGVSV AHKASEEIGA RPVRGRQGRI LRRAGLAVSL GITAMLVSGC    50
    SIDNVWLRFG WPSGVTPQAT RMRELWTWSI IAALAMGVLV WGLTFWTVVF 100
    HRKKKDSPEF PRQTGYNVPL ELTYTAIPFV IIAVLFYFTV VVQNYVHEKV 150
    ADPDVTVDVT AFQWNWKFGY REVDFKDGGY QFNGIDTARE EAAQAQLKEY 200
    EERVDTEHGH PQPGPVHGKP ENDILSYLHY DTVETVGTST EIPVLVLPTG 250
    KVIEFQLAAA DVIHAFWVPE FLFKRDVMPN PKENHSDNVF QITEIEKEGA 300
    FVGRCAEMCG TYHSMMNFEV RAVSPEKFTR YLDERRAGKT NAEALAAIGE 350
    SPVATSTRPF NTDRTVKSAA APEAE 375
    Length:375
    Mass (Da):41,976
    Last modified:November 23, 2004 - v1
    Checksum:i51FE78E89A462104
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD56554.1.
    RefSeqiYP_117918.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD56554; BAD56554; NFA_17080.
    GeneIDi3107212.
    KEGGinfa:nfa17080.
    PATRICi22733026. VBINocFar94200_1758.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD56554.1 .
    RefSeqi YP_117918.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5YZ37.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa17080.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD56554 ; BAD56554 ; NFA_17080 .
    GeneIDi 3107212.
    KEGGi nfa:nfa17080.
    PATRICi 22733026. VBINocFar94200_1758.

    Phylogenomic databases

    eggNOGi COG1622.
    KOi K02275.
    OMAi MRELWTW.
    OrthoDBi EOG68SVXT.

    Enzyme and pathway databases

    BioCyci NFAR247156:GJ9T-1746-MONOMER.

    Family and domain databases

    Gene3Di 1.10.287.90. 1 hit.
    2.60.40.420. 2 hits.
    InterProi IPR001505. Copper_CuA.
    IPR008972. Cupredoxin.
    IPR002429. Cyt_c_oxidase_su2_C.
    IPR011759. Cyt_c_oxidase_su2_TM_dom.
    [Graphical view ]
    Pfami PF00116. COX2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 2 hits.
    SSF81464. SSF81464. 1 hit.
    PROSITEi PS00078. COX2. 1 hit.
    PS50857. COX2_CUA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiCOX2_NOCFA
    AccessioniPrimary (citable) accession number: Q5YZ37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3