Q5YZ37 (COX2_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II

Gene names

Name:	ctaC
Ordered Locus Names:	NFA_17080

Organism

Nocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]

Taxonomic identifier

247156 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia › Nocardia farcinica

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) By similarity.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A By similarity. Heme group By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 375	375	Probable cytochrome c oxidase subunit 2		PRO_0000183718
Regions
	Transmembrane	36 – 56	21	Helical; Potential
	Transmembrane	80 – 100	21	Helical; Potential
	Transmembrane	122 – 142	21	Helical; Potential
Sites
	Metal binding	264	1	Copper A Potential
	Metal binding	305	1	Copper A Potential
	Metal binding	309	1	Copper A Potential
	Metal binding	313	1	Copper A Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5YZ37 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 51FE78E89A462104	FASTA	375	41,976
	10 20 30 40 50 60 MCGDQEGVSV AHKASEEIGA RPVRGRQGRI LRRAGLAVSL GITAMLVSGC SIDNVWLRFG 70 80 90 100 110 120 WPSGVTPQAT RMRELWTWSI IAALAMGVLV WGLTFWTVVF HRKKKDSPEF PRQTGYNVPL 130 140 150 160 170 180 ELTYTAIPFV IIAVLFYFTV VVQNYVHEKV ADPDVTVDVT AFQWNWKFGY REVDFKDGGY 190 200 210 220 230 240 QFNGIDTARE EAAQAQLKEY EERVDTEHGH PQPGPVHGKP ENDILSYLHY DTVETVGTST 250 260 270 280 290 300 EIPVLVLPTG KVIEFQLAAA DVIHAFWVPE FLFKRDVMPN PKENHSDNVF QITEIEKEGA 310 320 330 340 350 360 FVGRCAEMCG TYHSMMNFEV RAVSPEKFTR YLDERRAGKT NAEALAAIGE SPVATSTRPF 370 NTDRTVKSAA APEAE

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006618 Genomic DNA. Translation: BAD56554.1.
RefSeq	YP_117918.1. NC_006361.1.
3D structure databases
ProteinModelPortal	Q5YZ37.
ModBase	Search...
Protein-protein interaction databases
STRING	247156.nfa17080.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	BAD56554; BAD56554; NFA_17080.
GeneID	3107212.
KEGG	nfa:nfa17080.
PATRIC	22733026. VBINocFar94200_1758.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1622.
KO	K02275.
OMA	MRELWTW.
ProtClustDB	CLSK2765886.
Enzyme and pathway databases
BioCyc	NFAR247156:GJ9T-1746-MONOMER.
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 2 hits.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_NOCFA

Accession

Primary (citable) accession number: Q5YZ37

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	November 23, 2004
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program