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Q5YZ37

- COX2_NOCFA

UniProt

Q5YZ37 - COX2_NOCFA

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Protein

Probable cytochrome c oxidase subunit 2

Gene

ctaC

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationBy similarityNote: Binds a copper A center.By similarity
  • hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi264 – 2641Copper ASequence Analysis
Metal bindingi305 – 3051Copper ASequence Analysis
Metal bindingi309 – 3091Copper ASequence Analysis
Metal bindingi313 – 3131Copper ASequence Analysis

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. electron transport chain Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-1746-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 2
Cytochrome c oxidase polypeptide II
Gene namesi
Name:ctaC
Ordered Locus Names:NFA_17080
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei36 – 5621HelicalSequence AnalysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST
Transmembranei122 – 14221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 375375Probable cytochrome c oxidase subunit 2PRO_0000183718Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa17080.

Structurei

3D structure databases

ProteinModelPortaliQ5YZ37.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1622.
KOiK02275.
OMAiMRELWTW.
OrthoDBiEOG68SVXT.

Family and domain databases

Gene3Di1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YZ37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MCGDQEGVSV AHKASEEIGA RPVRGRQGRI LRRAGLAVSL GITAMLVSGC
60 70 80 90 100
SIDNVWLRFG WPSGVTPQAT RMRELWTWSI IAALAMGVLV WGLTFWTVVF
110 120 130 140 150
HRKKKDSPEF PRQTGYNVPL ELTYTAIPFV IIAVLFYFTV VVQNYVHEKV
160 170 180 190 200
ADPDVTVDVT AFQWNWKFGY REVDFKDGGY QFNGIDTARE EAAQAQLKEY
210 220 230 240 250
EERVDTEHGH PQPGPVHGKP ENDILSYLHY DTVETVGTST EIPVLVLPTG
260 270 280 290 300
KVIEFQLAAA DVIHAFWVPE FLFKRDVMPN PKENHSDNVF QITEIEKEGA
310 320 330 340 350
FVGRCAEMCG TYHSMMNFEV RAVSPEKFTR YLDERRAGKT NAEALAAIGE
360 370
SPVATSTRPF NTDRTVKSAA APEAE
Length:375
Mass (Da):41,976
Last modified:November 23, 2004 - v1
Checksum:i51FE78E89A462104
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD56554.1.
RefSeqiYP_117918.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD56554; BAD56554; NFA_17080.
GeneIDi3107212.
KEGGinfa:nfa17080.
PATRICi22733026. VBINocFar94200_1758.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD56554.1 .
RefSeqi YP_117918.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YZ37.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa17080.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD56554 ; BAD56554 ; NFA_17080 .
GeneIDi 3107212.
KEGGi nfa:nfa17080.
PATRICi 22733026. VBINocFar94200_1758.

Phylogenomic databases

eggNOGi COG1622.
KOi K02275.
OMAi MRELWTW.
OrthoDBi EOG68SVXT.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-1746-MONOMER.

Family and domain databases

Gene3Di 1.10.287.90. 1 hit.
2.60.40.420. 2 hits.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 2 hits.
SSF81464. SSF81464. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiCOX2_NOCFA
AccessioniPrimary (citable) accession number: Q5YZ37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3