Q5YZ05 (Q5YZ05_NOCFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Methylenetetrahydrofolate reductase RuleBase RU003862
EC=1.5.1.20 RuleBase RU003862

Gene names

Name:	metF EMBL BAD56586.1
Ordered Locus Names:	NFA_17400

Organism

Nocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]

Taxonomic identifier

247156 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H. RuleBase RU003862
Cofactor	FAD By similarity. RuleBase RU003862
Pathway	One-carbon metabolism; tetrahydrofolate pathway. RuleBase RU004255
Sequence similarities	Belongs to the methylenetetrahydrofolate reductase family. RuleBase RU003862

Ontologies

Keywords
Biological process	Amino-acid biosynthesis RuleBase RU004255
Ligand	FAD RuleBase RU003862 Flavoprotein RuleBase RU003862
Molecular function	Oxidoreductase RuleBase RU003862
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	methylenetetrahydrofolate reductase (NADPH) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5YZ05 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 15BBB5ADC448F7A0	FASTA	321	34,781
	10 20 30 40 50 60 MTFDPAPPHA AGTPSVVQSL RAHAGRSVPF SVEFNPPRDA AGEARLWRAV REFERMHPAF 70 80 90 100 110 120 VSMTYGAGGS TKDRTVRVTG QLAQETTLLP VAHLTAVGHS VAELRSLVGA YADSGIRNIL 130 140 150 160 170 180 VLRGDPPGDP LGEWHKHPEG VEYAEELVRI VRDLGDFHVG VASFPQGHHR SPDLATDTAF 190 200 210 220 230 240 LAAKLRAGAE YSITQMFFEV EHYLRLRDRL AALDPVEGAK PIIPELMPIT SLRTVTRAEE 250 260 270 280 290 300 LCGRPLPAAV LDRLRRAAGD GPEEDRAAVR EVGIEIATEM AQRLIDEGAP CLHFITLNFA 310 320 KATSEVLTNL GYGVTAAPVR A

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006618 Genomic DNA. Translation: BAD56586.1.
RefSeq	YP_117950.1. NC_006361.1.
3D structure databases
ProteinModelPortal	Q5YZ05.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3111282.
GenomeReviews	Gene locus NFA_17400 in contig AP006618_GR.
KEGG	nfa:nfa17400.
NMPDR	fig|247156.1.peg.1754.
PATRIC	22733092. VBINocFar94200_1791.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG649727.
OMA	ITQMFFD.
ProtClustDB	CLSK758165.
Family and domain databases
InterPro	IPR003171. Mehydrof_redctse. [Graphical view]
KO	K00297.
Pfam	PF02219. MTHFR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5YZ05_NOCFA

Accession

Primary (citable) accession number: Q5YZ05

Entry history

Integrated into UniProtKB/TrEMBL:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	December 14, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)