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Q5YYQ0

- HISX_NOCFA

UniProt

Q5YYQ0 - HISX_NOCFA

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Protein
Histidinol dehydrogenase
Gene
hisD, NFA_18450
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341NAD By similarity
Binding sitei198 – 1981NAD By similarity
Binding sitei226 – 2261NAD By similarity
Binding sitei249 – 2491Substrate By similarity
Metal bindingi271 – 2711Zinc By similarity
Binding sitei271 – 2711Substrate By similarity
Metal bindingi274 – 2741Zinc By similarity
Binding sitei274 – 2741Substrate By similarity
Active sitei340 – 3401Proton acceptor By similarity
Active sitei341 – 3411Proton acceptor By similarity
Binding sitei341 – 3411Substrate By similarity
Metal bindingi374 – 3741Zinc By similarity
Binding sitei374 – 3741Substrate By similarity
Binding sitei428 – 4281Substrate By similarity
Metal bindingi433 – 4331Zinc By similarity
Binding sitei433 – 4331Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-1886-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:NFA_18450
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Histidinol dehydrogenaseUniRule annotation
PRO_0000135806Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa18450.

Structurei

3D structure databases

ProteinModelPortaliQ5YYQ0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiDEMAMPI.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YYQ0-1 [UniParc]FASTAAdd to Basket

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MTSRIELARV DLRGRTPSTA ELRAALPRGG VDVDSVLHHV RPVVEAVRER    50
GAAAALEFGE KFDGVVPATV RVPAAELARA LDELDPAVRA ALEESIARAR 100
RVHADQRRTD TTTEVVPGGT VTERWVPVAR VGLYVPGGNA VYPSSVVMNV 150
VPAQTAGVGS LVVASPPQAN FGGLPHPTIL AAAALLGVEE VWAVGGAQAV 200
ALLSYGGTDT DGAPLDPVDL ITGPGNIYVT AAKRLCRGLV GIDAEAGPTE 250
IAILADATAD PAHVAADLIS QAEHDVLAAS VLVTDSVALA DAVDAALTAQ 300
LAVVKHAERV RTALTGKQSG TVLVDDITQG LRVVDAYAAE HLEIQTADAS 350
AVAARVRSAG AVFVGPYAPV SLGDYCAGSN HVLPTAGCAR HSSGLSVQTF 400
LRGIHVVEYT EAALKDVAGH VVALADAEDL PAHGQAVTVR FEALS 445
Length:445
Mass (Da):45,665
Last modified:November 23, 2004 - v1
Checksum:i90C2C883B64D9081
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD56691.1.
RefSeqiWP_011208376.1. NC_006361.1.
YP_118055.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD56691; BAD56691; NFA_18450.
GeneIDi3109568.
KEGGinfa:nfa18450.
PATRICi22733308. VBINocFar94200_1896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD56691.1 .
RefSeqi WP_011208376.1. NC_006361.1.
YP_118055.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YYQ0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa18450.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD56691 ; BAD56691 ; NFA_18450 .
GeneIDi 3109568.
KEGGi nfa:nfa18450.
PATRICi 22733308. VBINocFar94200_1896.

Phylogenomic databases

eggNOGi COG0141.
KOi K00013.
OMAi DEMAMPI.
OrthoDBi EOG6CVVCR.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci NFAR247156:GJ9T-1886-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiHISX_NOCFA
AccessioniPrimary (citable) accession number: Q5YYQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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