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Q5YYQ0

- HISX_NOCFA

UniProt

Q5YYQ0 - HISX_NOCFA

Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

    Catalytic activityi

    L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei134 – 1341NADUniRule annotation
    Binding sitei198 – 1981NADUniRule annotation
    Binding sitei226 – 2261NADUniRule annotation
    Binding sitei249 – 2491SubstrateUniRule annotation
    Metal bindingi271 – 2711ZincUniRule annotation
    Binding sitei271 – 2711SubstrateUniRule annotation
    Metal bindingi274 – 2741ZincUniRule annotation
    Binding sitei274 – 2741SubstrateUniRule annotation
    Active sitei340 – 3401Proton acceptorUniRule annotation
    Active sitei341 – 3411Proton acceptorUniRule annotation
    Binding sitei341 – 3411SubstrateUniRule annotation
    Metal bindingi374 – 3741ZincUniRule annotation
    Binding sitei374 – 3741SubstrateUniRule annotation
    Binding sitei428 – 4281SubstrateUniRule annotation
    Metal bindingi433 – 4331ZincUniRule annotation
    Binding sitei433 – 4331SubstrateUniRule annotation

    GO - Molecular functioni

    1. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
    2. NAD binding Source: InterPro
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-1886-MONOMER.
    UniPathwayiUPA00031; UER00014.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
    Short name:
    HDHUniRule annotation
    Gene namesi
    Name:hisDUniRule annotation
    Ordered Locus Names:NFA_18450
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445Histidinol dehydrogenasePRO_0000135806Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi247156.nfa18450.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5YYQ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histidinol dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0141.
    KOiK00013.
    OMAiDEMAMPI.
    OrthoDBiEOG6CVVCR.

    Family and domain databases

    HAMAPiMF_01024. HisD.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view]
    PfamiPF00815. Histidinol_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
    PRINTSiPR00083. HOLDHDRGNASE.
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR00069. hisD. 1 hit.
    PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5YYQ0-1 [UniParc]FASTAAdd to Basket

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    MTSRIELARV DLRGRTPSTA ELRAALPRGG VDVDSVLHHV RPVVEAVRER    50
    GAAAALEFGE KFDGVVPATV RVPAAELARA LDELDPAVRA ALEESIARAR 100
    RVHADQRRTD TTTEVVPGGT VTERWVPVAR VGLYVPGGNA VYPSSVVMNV 150
    VPAQTAGVGS LVVASPPQAN FGGLPHPTIL AAAALLGVEE VWAVGGAQAV 200
    ALLSYGGTDT DGAPLDPVDL ITGPGNIYVT AAKRLCRGLV GIDAEAGPTE 250
    IAILADATAD PAHVAADLIS QAEHDVLAAS VLVTDSVALA DAVDAALTAQ 300
    LAVVKHAERV RTALTGKQSG TVLVDDITQG LRVVDAYAAE HLEIQTADAS 350
    AVAARVRSAG AVFVGPYAPV SLGDYCAGSN HVLPTAGCAR HSSGLSVQTF 400
    LRGIHVVEYT EAALKDVAGH VVALADAEDL PAHGQAVTVR FEALS 445
    Length:445
    Mass (Da):45,665
    Last modified:November 23, 2004 - v1
    Checksum:i90C2C883B64D9081
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD56691.1.
    RefSeqiWP_011208376.1. NC_006361.1.
    YP_118055.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD56691; BAD56691; NFA_18450.
    GeneIDi3109568.
    KEGGinfa:nfa18450.
    PATRICi22733308. VBINocFar94200_1896.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD56691.1 .
    RefSeqi WP_011208376.1. NC_006361.1.
    YP_118055.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5YYQ0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa18450.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD56691 ; BAD56691 ; NFA_18450 .
    GeneIDi 3109568.
    KEGGi nfa:nfa18450.
    PATRICi 22733308. VBINocFar94200_1896.

    Phylogenomic databases

    eggNOGi COG0141.
    KOi K00013.
    OMAi DEMAMPI.
    OrthoDBi EOG6CVVCR.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00014 .
    BioCyci NFAR247156:GJ9T-1886-MONOMER.

    Family and domain databases

    HAMAPi MF_01024. HisD.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR001692. Histidinol_DH_CS.
    IPR022695. Histidinol_DH_monofunct.
    IPR012131. Hstdl_DH.
    [Graphical view ]
    Pfami PF00815. Histidinol_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
    PRINTSi PR00083. HOLDHDRGNASE.
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR00069. hisD. 1 hit.
    PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiHISX_NOCFA
    AccessioniPrimary (citable) accession number: Q5YYQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3