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Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathway:iL-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341NADUniRule annotation
Binding sitei198 – 1981NADUniRule annotation
Binding sitei226 – 2261NADUniRule annotation
Binding sitei249 – 2491SubstrateUniRule annotation
Metal bindingi271 – 2711ZincUniRule annotation
Binding sitei271 – 2711SubstrateUniRule annotation
Metal bindingi274 – 2741ZincUniRule annotation
Binding sitei274 – 2741SubstrateUniRule annotation
Active sitei340 – 3401Proton acceptorUniRule annotation
Active sitei341 – 3411Proton acceptorUniRule annotation
Binding sitei341 – 3411SubstrateUniRule annotation
Metal bindingi374 – 3741ZincUniRule annotation
Binding sitei374 – 3741SubstrateUniRule annotation
Binding sitei428 – 4281SubstrateUniRule annotation
Metal bindingi433 – 4331ZincUniRule annotation
Binding sitei433 – 4331SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-1886-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:NFA_18450
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
ProteomesiUP000006820 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Histidinol dehydrogenasePRO_0000135806Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa18450.

Structurei

3D structure databases

ProteinModelPortaliQ5YYQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YYQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSRIELARV DLRGRTPSTA ELRAALPRGG VDVDSVLHHV RPVVEAVRER
60 70 80 90 100
GAAAALEFGE KFDGVVPATV RVPAAELARA LDELDPAVRA ALEESIARAR
110 120 130 140 150
RVHADQRRTD TTTEVVPGGT VTERWVPVAR VGLYVPGGNA VYPSSVVMNV
160 170 180 190 200
VPAQTAGVGS LVVASPPQAN FGGLPHPTIL AAAALLGVEE VWAVGGAQAV
210 220 230 240 250
ALLSYGGTDT DGAPLDPVDL ITGPGNIYVT AAKRLCRGLV GIDAEAGPTE
260 270 280 290 300
IAILADATAD PAHVAADLIS QAEHDVLAAS VLVTDSVALA DAVDAALTAQ
310 320 330 340 350
LAVVKHAERV RTALTGKQSG TVLVDDITQG LRVVDAYAAE HLEIQTADAS
360 370 380 390 400
AVAARVRSAG AVFVGPYAPV SLGDYCAGSN HVLPTAGCAR HSSGLSVQTF
410 420 430 440
LRGIHVVEYT EAALKDVAGH VVALADAEDL PAHGQAVTVR FEALS
Length:445
Mass (Da):45,665
Last modified:November 23, 2004 - v1
Checksum:i90C2C883B64D9081
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD56691.1.
RefSeqiWP_011208376.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD56691; BAD56691; NFA_18450.
KEGGinfa:nfa18450.
PATRICi22733308. VBINocFar94200_1896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD56691.1.
RefSeqiWP_011208376.1. NC_006361.1.

3D structure databases

ProteinModelPortaliQ5YYQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi247156.nfa18450.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD56691; BAD56691; NFA_18450.
KEGGinfa:nfa18450.
PATRICi22733308. VBINocFar94200_1896.

Phylogenomic databases

eggNOGiCOG0141.
KOiK00013.
OMAiLSVQSFL.
OrthoDBiEOG6CVVCR.

Enzyme and pathway databases

UniPathwayiUPA00031; UER00014.
BioCyciNFAR247156:GJ9T-1886-MONOMER.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiHISX_NOCFA
AccessioniPrimary (citable) accession number: Q5YYQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: November 23, 2004
Last modified: July 22, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.