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Protein

Imidazoleglycerol-phosphate dehydratase

Gene

hisB

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00011.

Names & Taxonomyi

Protein namesi
Recommended name:
Imidazoleglycerol-phosphate dehydrataseUniRule annotation (EC:4.2.1.19UniRule annotation)
Short name:
IGPDUniRule annotation
Gene namesi
Name:hisBUniRule annotation
Ordered Locus Names:NFA_18470
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000006820 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001581501 – 216Imidazoleglycerol-phosphate dehydrataseAdd BLAST216

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa18470.

Structurei

3D structure databases

ProteinModelPortaliQ5YYP8.
SMRiQ5YYP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the imidazoleglycerol-phosphate dehydratase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105ECC. Bacteria.
COG0131. LUCA.
KOiK01693.
OMAiARHGLFD.
OrthoDBiPOG091H060Z.

Family and domain databases

CDDicd07914. IGPD. 1 hit.
HAMAPiMF_00076. HisB. 1 hit.
InterProiView protein in InterPro
IPR000807. ImidazoleglycerolP_deHydtase.
IPR020565. ImidazoleglycerP_deHydtase_CS.
IPR020568. Ribosomal_S5_D2-typ_fold.
PANTHERiPTHR23133. PTHR23133. 1 hit.
PfamiView protein in Pfam
PF00475. IGPD. 1 hit.
SUPFAMiSSF54211. SSF54211. 2 hits.
PROSITEiView protein in PROSITE
PS00954. IGP_DEHYDRATASE_1. 1 hit.
PS00955. IGP_DEHYDRATASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5YYP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDTTLRHRT ARVERVTKES SIVVELDLDG TGRTDISTGV PFYDHMLTAL
60 70 80 90 100
GAHASFDLSV RAEGDIQIEA HHTVEDTAIV FGQALGKALG DKAGIRRFGD
110 120 130 140 150
AFIPMDETLA HAAVDVSGRP YCVHTGEPEH LLHAVIPGSP VRGTGEPGAP
160 170 180 190 200
YSTVLNRHVF ESIALNARIA LHVRVLYGRD QHHVTEAEFK AVARALRAAV
210
EFDPRVSGVP STKGTL
Length:216
Mass (Da):23,301
Last modified:November 23, 2004 - v1
Checksum:iBBE36ED5192EA658
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD56693.1.
RefSeqiWP_011208378.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD56693; BAD56693; NFA_18470.
KEGGinfa:NFA_18470.

Similar proteinsi

Entry informationi

Entry nameiHIS7_NOCFA
AccessioniPrimary (citable) accession number: Q5YYP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 23, 2004
Last modified: June 7, 2017
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families