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Q5YY98 (NADK_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:NFA_19970
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324NAD kinase HAMAP-Rule MF_00361
PRO_0000229660

Regions

Nucleotide binding89 – 902NAD By similarity
Nucleotide binding163 – 1642NAD By similarity
Nucleotide binding204 – 2096NAD By similarity

Sites

Active site891Proton acceptor By similarity
Binding site941NAD By similarity
Binding site1931NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5YY98 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 16AED821C99E3385

FASTA32434,525
        10         20         30         40         50         60 
MSGSGDREIL LIAHPGRAEI VETAHRAAKI FTEAGIGLRV LADEAPSTRF DSRAEPAPVT 

        70         80         90        100        110        120 
GPAGDAVRVV EHSAAAAVGC EMVLALGGDG TFLRAAELAR PASVPVLGIN LGRIGFLTEA 

       130        140        150        160        170        180 
EAEHLDEALG QVVRGDYRVE DRMTIDVTVR VEDEVVESGW ALNEASIENA SRMGVLEVVL 

       190        200        210        220        230        240 
EVDGRPVSAF GCDGILIATP TGSTAYAFSA GGPVVWPELE ALLVIPSNAH ALFARPLVTS 

       250        260        270        280        290        300 
PESRIAVESV ATGHDAIVFL DGRRTLALPR GGRVEAVRGS EPVRWVRLDS APFADRMVRK 

       310        320 
FQLPVTGWRG RRRTESTRAD RDQD 

« Hide

References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006618 Genomic DNA. Translation: BAD56843.1.
RefSeqYP_118207.1. NC_006361.1.

3D structure databases

ProteinModelPortalQ5YY98.
SMRQ5YY98. Positions 4-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING247156.nfa19970.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD56843; BAD56843; NFA_19970.
GeneID3106676.
KEGGnfa:nfa19970.
PATRIC22733618. VBINocFar94200_2047.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
KOK00858.
OMAGVLWCDG.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycNFAR247156:GJ9T-2042-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_NOCFA
AccessionPrimary (citable) accession number: Q5YY98
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 23, 2004
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families