Q5YY98 (PPNK_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable inorganic polyphosphate/ATP-NAD kinase
Short name=Poly(P)/ATP NAD kinase
EC=2.7.1.23

Gene names

Name:	ppnK
Ordered Locus Names:	NFA_19970

Organism

Nocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]

Taxonomic identifier

247156 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus By similarity. HAMAP MF_00361
Catalytic activity	ATP + NAD+ = ADP + NADP+. HAMAP MF_00361
Cofactor	Divalent metal ions By similarity. HAMAP MF_00361
Subcellular location	Cytoplasm By similarity HAMAP MF_00361.
Sequence similarities	Belongs to the NAD kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding NAD NADP Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW NAD+ kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Probable inorganic polyphosphate/ATP-NAD kinase HAMAP MF_00361		PRO_0000229660

Sequences

	Sequence		Length	Mass (Da)
	Q5YY98 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 16AED821C99E3385	FASTA	324	34,525
	10 20 30 40 50 60 MSGSGDREIL LIAHPGRAEI VETAHRAAKI FTEAGIGLRV LADEAPSTRF DSRAEPAPVT 70 80 90 100 110 120 GPAGDAVRVV EHSAAAAVGC EMVLALGGDG TFLRAAELAR PASVPVLGIN LGRIGFLTEA 130 140 150 160 170 180 EAEHLDEALG QVVRGDYRVE DRMTIDVTVR VEDEVVESGW ALNEASIENA SRMGVLEVVL 190 200 210 220 230 240 EVDGRPVSAF GCDGILIATP TGSTAYAFSA GGPVVWPELE ALLVIPSNAH ALFARPLVTS 250 260 270 280 290 300 PESRIAVESV ATGHDAIVFL DGRRTLALPR GGRVEAVRGS EPVRWVRLDS APFADRMVRK 310 320 FQLPVTGWRG RRRTESTRAD RDQD

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006618 Genomic DNA. Translation: BAD56843.1.
RefSeq	YP_118207.1. NC_006361.1.
3D structure databases
ProteinModelPortal	Q5YY98.
SMR	Q5YY98. Positions 4-309.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3106676.
GenomeReviews	Gene locus NFA_19970 in contig AP006618_GR.
KEGG	nfa:nfa19970.
NMPDR	fig|247156.1.peg.2001.
PATRIC	22733618. VBINocFar94200_2047.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG713904.
OMA	GPVVWPE.
ProtClustDB	PRK03372.
Enzyme and pathway databases
BioCyc	NFAR247156:NFA19970-MONOMER.
Family and domain databases
HAMAP	MF_00361. NAD_kinase. [Tree]
InterPro	IPR016064. ATP-NAD_kinase_PpnK-typ. IPR017438. ATP-NAD_kinase_PpnK-typ_a/b. IPR017437. ATP-NAD_kinase_PpnK-typ_all-b. IPR002504. polyP/ATP_NADK_prd. [Graphical view]
Gene3D	G3DSA:2.60.200.30. ATP-NAD_kinase_PpnK-typ. 1 hit. G3DSA:3.40.50.10330. ATP-NAD_kinase_PpnK-typ_a/b. 1 hit.
KO	K00858.
PANTHER	PTHR20275. ATP_NADK. 1 hit.
Pfam	PF01513. NAD_kinase. 1 hit. [Graphical view]
SUPFAM	SSF111331. ATP-NAD_kinase_PpnK-typ. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PPNK_NOCFA

Accession

Primary (citable) accession number: Q5YY98

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program