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Q5YY98

- NADK_NOCFA

UniProt

Q5YY98 - NADK_NOCFA

Protein

NAD kinase

Gene

nadK

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei89 – 891Proton acceptorUniRule annotation
    Binding sitei94 – 941NADUniRule annotation
    Binding sitei193 – 1931NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi89 – 902NADUniRule annotation
    Nucleotide bindingi163 – 1642NADUniRule annotation
    Nucleotide bindingi204 – 2096NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-2042-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:NFA_19970
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324NAD kinasePRO_0000229660Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi247156.nfa19970.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5YY98.
    SMRiQ5YY98. Positions 4-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    KOiK00858.
    OMAiGVLWCDG.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5YY98-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGSGDREIL LIAHPGRAEI VETAHRAAKI FTEAGIGLRV LADEAPSTRF    50
    DSRAEPAPVT GPAGDAVRVV EHSAAAAVGC EMVLALGGDG TFLRAAELAR 100
    PASVPVLGIN LGRIGFLTEA EAEHLDEALG QVVRGDYRVE DRMTIDVTVR 150
    VEDEVVESGW ALNEASIENA SRMGVLEVVL EVDGRPVSAF GCDGILIATP 200
    TGSTAYAFSA GGPVVWPELE ALLVIPSNAH ALFARPLVTS PESRIAVESV 250
    ATGHDAIVFL DGRRTLALPR GGRVEAVRGS EPVRWVRLDS APFADRMVRK 300
    FQLPVTGWRG RRRTESTRAD RDQD 324
    Length:324
    Mass (Da):34,525
    Last modified:November 23, 2004 - v1
    Checksum:i16AED821C99E3385
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD56843.1.
    RefSeqiYP_118207.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD56843; BAD56843; NFA_19970.
    GeneIDi3106676.
    KEGGinfa:nfa19970.
    PATRICi22733618. VBINocFar94200_2047.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD56843.1 .
    RefSeqi YP_118207.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5YY98.
    SMRi Q5YY98. Positions 4-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa19970.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD56843 ; BAD56843 ; NFA_19970 .
    GeneIDi 3106676.
    KEGGi nfa:nfa19970.
    PATRICi 22733618. VBINocFar94200_2047.

    Phylogenomic databases

    eggNOGi COG0061.
    KOi K00858.
    OMAi GVLWCDG.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci NFAR247156:GJ9T-2042-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiNADK_NOCFA
    AccessioniPrimary (citable) accession number: Q5YY98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3