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Q5YY98

- NADK_NOCFA

UniProt

Q5YY98 - NADK_NOCFA

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Protein
NAD kinase
Gene
nadK, NFA_19970
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptor By similarity
Binding sitei94 – 941NAD By similarity
Binding sitei193 – 1931NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi89 – 902NAD By similarity
Nucleotide bindingi163 – 1642NAD By similarity
Nucleotide bindingi204 – 2096NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-2042-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:NFA_19970
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324NAD kinaseUniRule annotation
PRO_0000229660Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa19970.

Structurei

3D structure databases

ProteinModelPortaliQ5YY98.
SMRiQ5YY98. Positions 4-309.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5YY98-1 [UniParc]FASTAAdd to Basket

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MSGSGDREIL LIAHPGRAEI VETAHRAAKI FTEAGIGLRV LADEAPSTRF    50
DSRAEPAPVT GPAGDAVRVV EHSAAAAVGC EMVLALGGDG TFLRAAELAR 100
PASVPVLGIN LGRIGFLTEA EAEHLDEALG QVVRGDYRVE DRMTIDVTVR 150
VEDEVVESGW ALNEASIENA SRMGVLEVVL EVDGRPVSAF GCDGILIATP 200
TGSTAYAFSA GGPVVWPELE ALLVIPSNAH ALFARPLVTS PESRIAVESV 250
ATGHDAIVFL DGRRTLALPR GGRVEAVRGS EPVRWVRLDS APFADRMVRK 300
FQLPVTGWRG RRRTESTRAD RDQD 324
Length:324
Mass (Da):34,525
Last modified:November 23, 2004 - v1
Checksum:i16AED821C99E3385
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD56843.1.
RefSeqiYP_118207.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD56843; BAD56843; NFA_19970.
GeneIDi3106676.
KEGGinfa:nfa19970.
PATRICi22733618. VBINocFar94200_2047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD56843.1 .
RefSeqi YP_118207.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YY98.
SMRi Q5YY98. Positions 4-309.
ModBasei Search...

Protein-protein interaction databases

STRINGi 247156.nfa19970.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD56843 ; BAD56843 ; NFA_19970 .
GeneIDi 3106676.
KEGGi nfa:nfa19970.
PATRICi 22733618. VBINocFar94200_2047.

Phylogenomic databases

eggNOGi COG0061.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-2042-MONOMER.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiNADK_NOCFA
AccessioniPrimary (citable) accession number: Q5YY98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2006
Last sequence update: November 23, 2004
Last modified: July 9, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi