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Q5YWV4 (GCSP_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:NFA_24900
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia

Protein attributes

Sequence length934 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 934934Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000227110

Amino acid modifications

Modified residue6871N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5YWV4 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 3D1FE2DBA0B7A6F8

FASTA93499,249
        10         20         30         40         50         60 
MTRSFADRHI GPDAAELSRI LEVVGVDSLD ALAAAALPAS ILDDAGAGPL AALPPAVSEH 

        70         80         90        100        110        120 
EALAELAALA QSNTVTTSMI GLGYYDTLTP PVLVRNLLEN PAWYTAYTPY QPEISQGRLE 

       130        140        150        160        170        180 
ALLNFQTMVS DLTGMEVANA SMLDEATAAA EAMTLLRRAG RSRSNRLLID ADLFPQTRTV 

       190        200        210        220        230        240 
LHTRAEPLGI EIVEADLAAA GLPEGGFFGV IVQVPGASGR VVDWTALIAA AHERGALVAA 

       250        260        270        280        290        300 
GADLLAMTLI VPPGEQGADV CFGTTQRFGV PMGFGGPHAG YLAVRSAHAR QLPGRLVGVS 

       310        320        330        340        350        360 
KDADGNPAYR LALQTREQHI RREKATSNIC TAQVLLAIVA AMYACYHGAD GLRAIARRVH 

       370        380        390        400        410        420 
GHAARIAGAL GEALVHDTYF DTVLARVPGH AEAVVAKAAA CGITLRLVDP DHVAVACDEA 

       430        440        450        460        470        480 
TTDAHVEAVL DAFGVAPAEP VDAGIATRTS EFLTHPAFTR YRTETAMLRY LRSLSDKDIA 

       490        500        510        520        530        540 
LDRSMIPLGS CTMKLNATAE MEPITWPGFA KLHPYAPVEH APGLLKLIGD LESWLAEITG 

       550        560        570        580        590        600 
YDAVSLQPNA GSQGEYAGLL AIRRYHLDRG DTHRDTCLIP SSAHGTNAAS AAMAGLRVEV 

       610        620        630        640        650        660 
VKCRENGDVD LDDLRAKITD HAERLACIMI TYPSTHGVYE HEIAELCALV HDAGGQVYVD 

       670        680        690        700        710        720 
GANLNALVGL ARPGRFGGDV SHLNLHKTFC IPHGGGGPGV GPVAVRAHLA QYLPGDPLES 

       730        740        750        760        770        780 
GSHAVSAARY GSASILPITW AYIRMMGAEG LRKATLTAIA SANYLARRLD EYFPVLYTGE 

       790        800        810        820        830        840 
NGMVAHECIL DLRELTKRTG VTVDDVAKRL ADYGFHAPTM SFPVAGTLMV EPTESENLAE 

       850        860        870        880        890        900 
LDEFVAAMIA IRAEIDQVGA GVWPAEDNPL RGAPHTAECL VGEWTHPYSR EIAVYPRGLG 

       910        920        930 
HARAKVWPAV RRIDGAYGDR NLVCSCPPLE AYAE 

« Hide

References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006618 Genomic DNA. Translation: BAD57337.1.
RefSeqYP_118701.1. NC_006361.1.

3D structure databases

ProteinModelPortalQ5YWV4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING247156.nfa24900.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD57337; BAD57337; NFA_24900.
GeneID3109643.
KEGGnfa:nfa24900.
PATRIC22734606. VBINocFar94200_2540.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
KOK00281.
OMAFHQYRSE.
OrthoDBEOG6HMXDX.

Enzyme and pathway databases

BioCycNFAR247156:GJ9T-2537-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_NOCFA
AccessionPrimary (citable) accession number: Q5YWV4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families