Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q5YWV4

- GCSP_NOCFA

UniProt

Q5YWV4 - GCSP_NOCFA

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-2537-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:NFA_24900
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 934934Glycine dehydrogenase (decarboxylating)PRO_0000227110Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei687 – 6871N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi247156.nfa24900.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5YWV4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    KOiK00281.
    OMAiFHQYRSE.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5YWV4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTRSFADRHI GPDAAELSRI LEVVGVDSLD ALAAAALPAS ILDDAGAGPL    50
    AALPPAVSEH EALAELAALA QSNTVTTSMI GLGYYDTLTP PVLVRNLLEN 100
    PAWYTAYTPY QPEISQGRLE ALLNFQTMVS DLTGMEVANA SMLDEATAAA 150
    EAMTLLRRAG RSRSNRLLID ADLFPQTRTV LHTRAEPLGI EIVEADLAAA 200
    GLPEGGFFGV IVQVPGASGR VVDWTALIAA AHERGALVAA GADLLAMTLI 250
    VPPGEQGADV CFGTTQRFGV PMGFGGPHAG YLAVRSAHAR QLPGRLVGVS 300
    KDADGNPAYR LALQTREQHI RREKATSNIC TAQVLLAIVA AMYACYHGAD 350
    GLRAIARRVH GHAARIAGAL GEALVHDTYF DTVLARVPGH AEAVVAKAAA 400
    CGITLRLVDP DHVAVACDEA TTDAHVEAVL DAFGVAPAEP VDAGIATRTS 450
    EFLTHPAFTR YRTETAMLRY LRSLSDKDIA LDRSMIPLGS CTMKLNATAE 500
    MEPITWPGFA KLHPYAPVEH APGLLKLIGD LESWLAEITG YDAVSLQPNA 550
    GSQGEYAGLL AIRRYHLDRG DTHRDTCLIP SSAHGTNAAS AAMAGLRVEV 600
    VKCRENGDVD LDDLRAKITD HAERLACIMI TYPSTHGVYE HEIAELCALV 650
    HDAGGQVYVD GANLNALVGL ARPGRFGGDV SHLNLHKTFC IPHGGGGPGV 700
    GPVAVRAHLA QYLPGDPLES GSHAVSAARY GSASILPITW AYIRMMGAEG 750
    LRKATLTAIA SANYLARRLD EYFPVLYTGE NGMVAHECIL DLRELTKRTG 800
    VTVDDVAKRL ADYGFHAPTM SFPVAGTLMV EPTESENLAE LDEFVAAMIA 850
    IRAEIDQVGA GVWPAEDNPL RGAPHTAECL VGEWTHPYSR EIAVYPRGLG 900
    HARAKVWPAV RRIDGAYGDR NLVCSCPPLE AYAE 934
    Length:934
    Mass (Da):99,249
    Last modified:November 23, 2004 - v1
    Checksum:i3D1FE2DBA0B7A6F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD57337.1.
    RefSeqiWP_011209022.1. NC_006361.1.
    YP_118701.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD57337; BAD57337; NFA_24900.
    GeneIDi3109643.
    KEGGinfa:nfa24900.
    PATRICi22734606. VBINocFar94200_2540.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD57337.1 .
    RefSeqi WP_011209022.1. NC_006361.1.
    YP_118701.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5YWV4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa24900.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD57337 ; BAD57337 ; NFA_24900 .
    GeneIDi 3109643.
    KEGGi nfa:nfa24900.
    PATRICi 22734606. VBINocFar94200_2540.

    Phylogenomic databases

    eggNOGi COG1003.
    KOi K00281.
    OMAi FHQYRSE.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci NFAR247156:GJ9T-2537-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiGCSP_NOCFA
    AccessioniPrimary (citable) accession number: Q5YWV4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 7, 2006
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3