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Q5YWV4

- GCSP_NOCFA

UniProt

Q5YWV4 - GCSP_NOCFA

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, NFA_24900
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-2537-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:NFA_24900
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 934934Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_0000227110Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei687 – 6871N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi247156.nfa24900.

Structurei

3D structure databases

ProteinModelPortaliQ5YWV4.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
KOiK00281.
OMAiFHQYRSE.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5YWV4-1 [UniParc]FASTAAdd to Basket

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MTRSFADRHI GPDAAELSRI LEVVGVDSLD ALAAAALPAS ILDDAGAGPL    50
AALPPAVSEH EALAELAALA QSNTVTTSMI GLGYYDTLTP PVLVRNLLEN 100
PAWYTAYTPY QPEISQGRLE ALLNFQTMVS DLTGMEVANA SMLDEATAAA 150
EAMTLLRRAG RSRSNRLLID ADLFPQTRTV LHTRAEPLGI EIVEADLAAA 200
GLPEGGFFGV IVQVPGASGR VVDWTALIAA AHERGALVAA GADLLAMTLI 250
VPPGEQGADV CFGTTQRFGV PMGFGGPHAG YLAVRSAHAR QLPGRLVGVS 300
KDADGNPAYR LALQTREQHI RREKATSNIC TAQVLLAIVA AMYACYHGAD 350
GLRAIARRVH GHAARIAGAL GEALVHDTYF DTVLARVPGH AEAVVAKAAA 400
CGITLRLVDP DHVAVACDEA TTDAHVEAVL DAFGVAPAEP VDAGIATRTS 450
EFLTHPAFTR YRTETAMLRY LRSLSDKDIA LDRSMIPLGS CTMKLNATAE 500
MEPITWPGFA KLHPYAPVEH APGLLKLIGD LESWLAEITG YDAVSLQPNA 550
GSQGEYAGLL AIRRYHLDRG DTHRDTCLIP SSAHGTNAAS AAMAGLRVEV 600
VKCRENGDVD LDDLRAKITD HAERLACIMI TYPSTHGVYE HEIAELCALV 650
HDAGGQVYVD GANLNALVGL ARPGRFGGDV SHLNLHKTFC IPHGGGGPGV 700
GPVAVRAHLA QYLPGDPLES GSHAVSAARY GSASILPITW AYIRMMGAEG 750
LRKATLTAIA SANYLARRLD EYFPVLYTGE NGMVAHECIL DLRELTKRTG 800
VTVDDVAKRL ADYGFHAPTM SFPVAGTLMV EPTESENLAE LDEFVAAMIA 850
IRAEIDQVGA GVWPAEDNPL RGAPHTAECL VGEWTHPYSR EIAVYPRGLG 900
HARAKVWPAV RRIDGAYGDR NLVCSCPPLE AYAE 934
Length:934
Mass (Da):99,249
Last modified:November 23, 2004 - v1
Checksum:i3D1FE2DBA0B7A6F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD57337.1.
RefSeqiWP_011209022.1. NC_006361.1.
YP_118701.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD57337; BAD57337; NFA_24900.
GeneIDi3109643.
KEGGinfa:nfa24900.
PATRICi22734606. VBINocFar94200_2540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD57337.1 .
RefSeqi WP_011209022.1. NC_006361.1.
YP_118701.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YWV4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa24900.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD57337 ; BAD57337 ; NFA_24900 .
GeneIDi 3109643.
KEGGi nfa:nfa24900.
PATRICi 22734606. VBINocFar94200_2540.

Phylogenomic databases

eggNOGi COG1003.
KOi K00281.
OMAi FHQYRSE.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-2537-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiGCSP_NOCFA
AccessioniPrimary (citable) accession number: Q5YWV4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi