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Q5YWU1

- MASZ_NOCFA

UniProt

Q5YWU1 - MASZ_NOCFA

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Protein
Malate synthase G
Gene
glcB, NFA_25030
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Acetyl-CoA; via carbonyl oxygen By similarity
Binding sitei276 – 2761Acetyl-CoA By similarity
Binding sitei313 – 3131Acetyl-CoA By similarity
Active sitei340 – 3401Proton acceptor By similarity
Binding sitei340 – 3401Glyoxylate By similarity
Metal bindingi432 – 4321Magnesium By similarity
Binding sitei432 – 4321Glyoxylate By similarity
Metal bindingi460 – 4601Magnesium By similarity
Binding sitei541 – 5411Acetyl-CoA; via carbonyl oxygen By similarity
Active sitei632 – 6321Proton donor By similarity

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-HAMAP
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-2550-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthase G (EC:2.3.3.9)
Gene namesi
Name:glcB
Ordered Locus Names:NFA_25030
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 726726Malate synthase GUniRule annotation
PRO_1000056915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei618 – 6181Cysteine sulfenic acid (-SOH) By similarity

Keywords - PTMi

Oxidation

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi247156.nfa25030.

Structurei

3D structure databases

ProteinModelPortaliQ5YWU1.
SMRiQ5YWU1. Positions 2-722.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 1262Acetyl-CoA binding By similarity
Regioni457 – 4604Glyoxylate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2225.
KOiK01638.
OMAiSTIMDFE.
OrthoDBiEOG6HJ286.

Family and domain databases

Gene3Di2.170.170.11. 2 hits.
HAMAPiMF_00641. Malate_synth_G.
InterProiIPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01345. malate_syn_G. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5YWU1-1 [UniParc]FASTAAdd to Basket

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MTERIQVGGL QVAKVLHDFI ENEALPGSGV DSAAFWAGAE QVITDLAPRN    50
RALLAERDEI QGKLDAWHAE HPGANYDKAA YKSFLTEIGY LRPEPADFQI 100
TTQNVDSEIA ETAGPQLVVP VMNARFAINA ANARWGSLYD ALYGTDAIPE 150
DNGAEKGTGY NKVRGDKVIE WARNFLDDAV TLITGSHIGS TSYAIVDGEL 200
EVGLEDGTTI GLADASQLVG YQGDPAKPTS ILLKHNGLHI DIQIDPESPI 250
GSTDTAGIKD IVLESAVTTI MDFEDSVAAV DAEDKVLCYH NWLGLMQGTL 300
AEEVSKGGKT FTRTMNPDRV YTALDGSELR LHGRSLLFVR NVGHLMTSDA 350
ILDAQGNEVP EGIMDGLITS LIAKHSLRED VELKNSRTGS VYIVKPKMHG 400
PDEVAFTNEL FGRIEDVLGL ARNTLKVGIM DEERRTTVNL KACIEAAKER 450
VVFINTGFLD RTGDEIHTSM EAGPMVRKAD MKSQQWIASY EDWNVDTGLA 500
TGLPGKAQIG KGMWAMPDLM ADMLAQKIGH PKSGANTAWV PSPTAATLHA 550
THYHLVDVFK RQAEIAKGGR RASVDEILEI PLAANPNWSP EEIRQELDNN 600
SQSILGYVVR WIDQGVGCSK VPDIKDVALM EDRATLRISS QLMANWLRHG 650
IVTADEVVAS LERMAPVVDR QNAGDPNYRP MAPDFDGSIA FQAAKELILE 700
GTKQPNGYTE PILHRRRREA KALSRV 726
Length:726
Mass (Da):79,260
Last modified:November 23, 2004 - v1
Checksum:i633308E4D3C79077
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD57350.1.
RefSeqiWP_011209035.1. NC_006361.1.
YP_118714.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD57350; BAD57350; NFA_25030.
GeneIDi3109647.
KEGGinfa:nfa25030.
PATRICi22734632. VBINocFar94200_2553.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD57350.1 .
RefSeqi WP_011209035.1. NC_006361.1.
YP_118714.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YWU1.
SMRi Q5YWU1. Positions 2-722.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa25030.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD57350 ; BAD57350 ; NFA_25030 .
GeneIDi 3109647.
KEGGi nfa:nfa25030.
PATRICi 22734632. VBINocFar94200_2553.

Phylogenomic databases

eggNOGi COG2225.
KOi K01638.
OMAi STIMDFE.
OrthoDBi EOG6HJ286.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci NFAR247156:GJ9T-2550-MONOMER.

Family and domain databases

Gene3Di 2.170.170.11. 2 hits.
HAMAPi MF_00641. Malate_synth_G.
InterProi IPR011076. Malate_synth-like.
IPR023310. Malate_synth_G_beta_sub_dom.
IPR001465. Malate_synthase.
IPR006253. Malate_synthG.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01345. malate_syn_G. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiMASZ_NOCFA
AccessioniPrimary (citable) accession number: Q5YWU1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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