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Q5YVL4 (UPPP_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:NFA_29300
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 313313Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151171

Regions

Transmembrane121 – 14121Helical; Potential
Transmembrane152 – 17221Helical; Potential
Transmembrane187 – 20721Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane259 – 27921Helical; Potential
Transmembrane290 – 31021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q5YVL4 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: C14C28003FEA0FCE

FASTA31333,709
        10         20         30         40         50         60 
MGESMTWVQA LVLGLVQGLT EFLPISSSAH LRIVSSVFFG EDAGASFTAV TQLGTEAAVL 

        70         80         90        100        110        120 
VYFAKDIWRI LVAWTTTLWD KARAATGPRV PIHDRPTTRL PVLTADNEHR FAAEAQRELD 

       130        140        150        160        170        180 
YRIGWYVIIA TIPIGVLGFL FKDEIRTGAR NLWLVSFMLI AFALVIAAAE HYGAKRRPIE 

       190        200        210        220        230        240 
QLTTRDGLVM GFAQCLALIP GVSRSGATSS AGLFLGLERE AAVRFSFLLA IPAVTASGLF 

       250        260        270        280        290        300 
SLPDAFEPAG EGLNASGPQL LVATIVSFVV GYASVAWLLK FVARHSLNWF VGYRIVLGLV 

       310 
IMGLLGAGVI SAT 

« Hide

References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006618 Genomic DNA. Translation: BAD57777.1.
RefSeqYP_119141.1. NC_006361.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING247156.nfa29300.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD57777; BAD57777; NFA_29300.
GeneID3107074.
KEGGnfa:nfa29300.
PATRIC22735464. VBINocFar94200_2968.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
KOK06153.
OMAAQCFALI.
OrthoDBEOG6QP13M.
ProtClustDBPRK00281.

Enzyme and pathway databases

BioCycNFAR247156:GJ9T-2979-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_NOCFA
AccessionPrimary (citable) accession number: Q5YVL4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: February 19, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families