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Q5YVL4

- UPPP_NOCFA

UniProt

Q5YVL4 - UPPP_NOCFA

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Protein
Undecaprenyl-diphosphatase
Gene
uppP, NFA_29300
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-2979-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:NFA_29300
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei121 – 14121Helical; Reviewed prediction
Add
BLAST
Transmembranei152 – 17221Helical; Reviewed prediction
Add
BLAST
Transmembranei187 – 20721Helical; Reviewed prediction
Add
BLAST
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST
Transmembranei259 – 27921Helical; Reviewed prediction
Add
BLAST
Transmembranei290 – 31021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 313313Undecaprenyl-diphosphataseUniRule annotation
PRO_0000151171Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa29300.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
KOiK06153.
OMAiIEGPFRD.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YVL4-1 [UniParc]FASTAAdd to Basket

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MGESMTWVQA LVLGLVQGLT EFLPISSSAH LRIVSSVFFG EDAGASFTAV    50
TQLGTEAAVL VYFAKDIWRI LVAWTTTLWD KARAATGPRV PIHDRPTTRL 100
PVLTADNEHR FAAEAQRELD YRIGWYVIIA TIPIGVLGFL FKDEIRTGAR 150
NLWLVSFMLI AFALVIAAAE HYGAKRRPIE QLTTRDGLVM GFAQCLALIP 200
GVSRSGATSS AGLFLGLERE AAVRFSFLLA IPAVTASGLF SLPDAFEPAG 250
EGLNASGPQL LVATIVSFVV GYASVAWLLK FVARHSLNWF VGYRIVLGLV 300
IMGLLGAGVI SAT 313
Length:313
Mass (Da):33,709
Last modified:November 23, 2004 - v1
Checksum:iC14C28003FEA0FCE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD57777.1.
RefSeqiWP_011209462.1. NC_006361.1.
YP_119141.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD57777; BAD57777; NFA_29300.
GeneIDi3107074.
KEGGinfa:nfa29300.
PATRICi22735464. VBINocFar94200_2968.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD57777.1 .
RefSeqi WP_011209462.1. NC_006361.1.
YP_119141.1. NC_006361.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa29300.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD57777 ; BAD57777 ; NFA_29300 .
GeneIDi 3107074.
KEGGi nfa:nfa29300.
PATRICi 22735464. VBINocFar94200_2968.

Phylogenomic databases

eggNOGi COG1968.
KOi K06153.
OMAi IEGPFRD.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-2979-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiUPPP_NOCFA
AccessioniPrimary (citable) accession number: Q5YVL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi