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Q5YV94

- ACDH2_NOCFA

UniProt

Q5YV94 - ACDH2_NOCFA

Protein

Acetaldehyde dehydrogenase 2

Gene

NFA_30500

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

    Catalytic activityi

    Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei126 – 1261Acyl-thioester intermediateUniRule annotation
    Binding sitei266 – 2661NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 144NADUniRule annotation
    Nucleotide bindingi157 – 1659NADUniRule annotation

    GO - Molecular functioni

    1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. NAD binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic compound catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Aromatic hydrocarbons catabolism

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-3099-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetaldehyde dehydrogenase 2UniRule annotation (EC:1.2.1.10UniRule annotation)
    Alternative name(s):
    Acetaldehyde dehydrogenase [acetylating] 2UniRule annotation
    Gene namesi
    Ordered Locus Names:NFA_30500
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Acetaldehyde dehydrogenase 2PRO_0000387696Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi247156.nfa30500.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5YV94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG4569.
    OMAiQPELPDF.
    OrthoDBiEOG6H1PXH.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01657. Ac_ald_DH_ac.
    InterProiIPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view]
    PfamiPF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTiSM00859. Semialdhyde_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q5YV94-1 [UniParc]FASTAAdd to Basket

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    MSRWKAAIVG SGNIGTDLMY KLLRSEHVDP VYMVGIDPAS EGLARAAQEG    50
    LDASAEGVDW LLSRRELPDV VFEATSAKVH AAAAPRYAAA GITAIDLTPA 100
    SVGPYVVPAV NLHEHLDAPN LNMVSCAGQA TIPILAAINR VADASYGEIV 150
    AAIASHSAGP GTRQNLSEFS EKTGRALAQV AGADRAKAIS VINPAEPPMN 200
    MRDTVYAKVR NPDADAIERA VLDMVAEVQR YVPGYTLRLI DVDGDLVTVM 250
    LEVVGAGDFL PTYAGNLDII TAAAVQVADV LAQRTLVEEP AR 292
    Length:292
    Mass (Da):30,705
    Last modified:November 23, 2004 - v1
    Checksum:i161475CA27BFC6DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD57897.1.
    RefSeqiYP_119261.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD57897; BAD57897; NFA_30500.
    GeneIDi3108504.
    KEGGinfa:nfa30500.
    PATRICi22735720. VBINocFar94200_3096.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD57897.1 .
    RefSeqi YP_119261.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5YV94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa30500.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD57897 ; BAD57897 ; NFA_30500 .
    GeneIDi 3108504.
    KEGGi nfa:nfa30500.
    PATRICi 22735720. VBINocFar94200_3096.

    Phylogenomic databases

    eggNOGi COG4569.
    OMAi QPELPDF.
    OrthoDBi EOG6H1PXH.

    Enzyme and pathway databases

    BioCyci NFAR247156:GJ9T-3099-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01657. Ac_ald_DH_ac.
    InterProi IPR003361. Acetaldehyde_dehydrogenase.
    IPR015426. Acetylaldehyde_DH_C.
    IPR016040. NAD(P)-bd_dom.
    IPR000534. Semialdehyde_DH_NAD-bd.
    [Graphical view ]
    Pfami PF09290. AcetDehyd-dimer. 1 hit.
    PF01118. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
    SMARTi SM00859. Semialdhyde_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiACDH2_NOCFA
    AccessioniPrimary (citable) accession number: Q5YV94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 3, 2009
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3