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Protein

Acetaldehyde dehydrogenase 3

Gene

NFA_33190

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351Acyl-thioester intermediateUniRule annotation
Binding sitei298 – 2981NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 204NADUniRule annotation
Nucleotide bindingi166 – 1749NADUniRule annotation

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-3368-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3UniRule annotation (EC:1.2.1.10UniRule annotation)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3UniRule annotation
Gene namesi
Ordered Locus Names:NFA_33190
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Acetaldehyde dehydrogenase 3PRO_0000387697Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa33190.

Structurei

3D structure databases

ProteinModelPortaliQ5YUH5.
SMRiQ5YUH5. Positions 10-320.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acetaldehyde dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG4569.
KOiK04073.
OMAiMIKVIRH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5YUH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNHMSDPTTV KVAVIGSGNI GTDLMIKVIR HSRVLEMGAM VGIDPDSDGL
60 70 80 90 100
ARARRLGVPT TSDGVEGLLA LPGFADIEVI FDATSAKAHA ANAALLQPLG
110 120 130 140 150
KRLIDLTPAA LGPFVVPAVN VDEHRDAPNV NMVTCGGQAT IPIVAAVSRV
160 170 180 190 200
APVAYAEIVA SIASKSAGPG TRANIDEFTE TTAHAVETVG GARRGKAIII
210 220 230 240 250
LNPAEPPLIM RDTVLCLATA PDPATRSAIR ESIEEMVARV AGYVPGYRLK
260 270 280 290 300
QQIQITEIPP DQPVHTLAAD GGPAPTHQVS VFLEVEGAAH YLPSYAGNLD
310 320
IMTSAALRYA ESIAATVTAA PADQGATR
Length:328
Mass (Da):34,005
Last modified:November 23, 2004 - v1
Checksum:i667A5FEAB2656F97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD58166.1.
RefSeqiWP_011209851.1. NC_006361.1.
YP_119530.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD58166; BAD58166; NFA_33190.
KEGGinfa:nfa33190.
PATRICi22736264. VBINocFar94200_3368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD58166.1.
RefSeqiWP_011209851.1. NC_006361.1.
YP_119530.1. NC_006361.1.

3D structure databases

ProteinModelPortaliQ5YUH5.
SMRiQ5YUH5. Positions 10-320.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi247156.nfa33190.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD58166; BAD58166; NFA_33190.
KEGGinfa:nfa33190.
PATRICi22736264. VBINocFar94200_3368.

Phylogenomic databases

eggNOGiCOG4569.
KOiK04073.
OMAiMIKVIRH.
OrthoDBiEOG6H1PXH.

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-3368-MONOMER.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiACDH3_NOCFA
AccessioniPrimary (citable) accession number: Q5YUH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 23, 2004
Last modified: April 1, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.