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Q5YUH5

- ACDH3_NOCFA

UniProt

Q5YUH5 - ACDH3_NOCFA

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Protein

Acetaldehyde dehydrogenase 3

Gene
NFA_33190
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD+ and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds By similarity.UniRule annotation

Catalytic activityi

Acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei135 – 1351Acyl-thioester intermediate By similarity
Binding sitei298 – 2981NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 204NAD By similarity
Nucleotide bindingi166 – 1749NAD By similarity

GO - Molecular functioni

  1. acetaldehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. NAD binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic compound catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Aromatic hydrocarbons catabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-3368-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetaldehyde dehydrogenase 3 (EC:1.2.1.10)
Alternative name(s):
Acetaldehyde dehydrogenase [acetylating] 3
Gene namesi
Ordered Locus Names:NFA_33190
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Acetaldehyde dehydrogenase 3UniRule annotationPRO_0000387697Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa33190.

Structurei

3D structure databases

ProteinModelPortaliQ5YUH5.
SMRiQ5YUH5. Positions 10-320.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG4569.
KOiK04073.
OMAiFTETTAH.
OrthoDBiEOG6H1PXH.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_01657. Ac_ald_DH_ac.
InterProiIPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view]
PfamiPF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTiSM00859. Semialdhyde_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03215. ac_ald_DH_ac. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5YUH5-1 [UniParc]FASTAAdd to Basket

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MNHMSDPTTV KVAVIGSGNI GTDLMIKVIR HSRVLEMGAM VGIDPDSDGL    50
ARARRLGVPT TSDGVEGLLA LPGFADIEVI FDATSAKAHA ANAALLQPLG 100
KRLIDLTPAA LGPFVVPAVN VDEHRDAPNV NMVTCGGQAT IPIVAAVSRV 150
APVAYAEIVA SIASKSAGPG TRANIDEFTE TTAHAVETVG GARRGKAIII 200
LNPAEPPLIM RDTVLCLATA PDPATRSAIR ESIEEMVARV AGYVPGYRLK 250
QQIQITEIPP DQPVHTLAAD GGPAPTHQVS VFLEVEGAAH YLPSYAGNLD 300
IMTSAALRYA ESIAATVTAA PADQGATR 328
Length:328
Mass (Da):34,005
Last modified:November 23, 2004 - v1
Checksum:i667A5FEAB2656F97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD58166.1.
RefSeqiWP_011209851.1. NC_006361.1.
YP_119530.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD58166; BAD58166; NFA_33190.
GeneIDi3107663.
KEGGinfa:nfa33190.
PATRICi22736264. VBINocFar94200_3368.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD58166.1 .
RefSeqi WP_011209851.1. NC_006361.1.
YP_119530.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YUH5.
SMRi Q5YUH5. Positions 10-320.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa33190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD58166 ; BAD58166 ; NFA_33190 .
GeneIDi 3107663.
KEGGi nfa:nfa33190.
PATRICi 22736264. VBINocFar94200_3368.

Phylogenomic databases

eggNOGi COG4569.
KOi K04073.
OMAi FTETTAH.
OrthoDBi EOG6H1PXH.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-3368-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_01657. Ac_ald_DH_ac.
InterProi IPR003361. Acetaldehyde_dehydrogenase.
IPR015426. Acetylaldehyde_DH_C.
IPR016040. NAD(P)-bd_dom.
IPR000534. Semialdehyde_DH_NAD-bd.
[Graphical view ]
Pfami PF09290. AcetDehyd-dimer. 1 hit.
PF01118. Semialdhyde_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF015689. Actaldh_dh_actl. 1 hit.
SMARTi SM00859. Semialdhyde_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03215. ac_ald_DH_ac. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiACDH3_NOCFA
AccessioniPrimary (citable) accession number: Q5YUH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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