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Q5YTQ5 (PGK_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:NFA_35880
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 410410Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_1000009639

Regions

Nucleotide binding360 – 3634ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site401Substrate By similarity
Binding site1221Substrate By similarity
Binding site1621Substrate By similarity
Binding site2121ATP By similarity
Binding site3001ATP; via carbonyl oxygen By similarity
Binding site3311ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5YTQ5 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 37A5875F2363D7E5

FASTA41042,608
        10         20         30         40         50         60 
MAVKTLQDLL NEGVEGRGVL VRSDLNVPLD DNGQITDPGR IIASIPTLKA LVEAGAKVVV 

        70         80         90        100        110        120 
TAHLGRPKGE PDPKFSLAPV AAKLAELLGR NVQLAGDVVG YDALSRSEGL TDGDVLLLEN 

       130        140        150        160        170        180 
VRFDPRETSK DEAERGKLAA ALVELVGEDG AFVSDGFGVV HRKQASVYDV AKLLPHYAGT 

       190        200        210        220        230        240 
LVAAEVDVLA KLTDNTERPY AVVLGGSKVS DKLAVIEALA PKVDTLVIGG GMCFTFLAAQ 

       250        260        270        280        290        300 
GLSVGSSLLQ EEMIDTCKGL LERYADVIHL PRDVVVADSF SADAESKCVP ANEIPDGWMG 

       310        320        330        340        350        360 
LDIGAESVDR FAALLTEAKT VFWNGPMGVF EFEKFAAGTR GVAEAIVAAT GKGAFTVVGG 

       370        380        390        400        410 
GDSAAAVRAL GLPEDGFSHI STGGGASLEY LEGKELPGIS VLEDTAPEGS 

« Hide

References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006618 Genomic DNA. Translation: BAD58436.1.
RefSeqYP_119800.1. NC_006361.1.

3D structure databases

ProteinModelPortalQ5YTQ5.
SMRQ5YTQ5. Positions 3-406.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING247156.nfa35880.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD58436; BAD58436; NFA_35880.
GeneID3111366.
KEGGnfa:nfa35880.
PATRIC22736792. VBINocFar94200_3632.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
KOK00927.
OMAGLDCGEK.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

BioCycNFAR247156:GJ9T-3638-MONOMER.
UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_NOCFA
AccessionPrimary (citable) accession number: Q5YTQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 23, 2004
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways