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Q5YTM1 (Q5YTM1_NOCFA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroorotase RuleBase RU003441
EC=3.5.2.3 RuleBase RU003441
Gene names
Ordered Locus Names:NFA_36220
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. RuleBase RU003441 SAAS SAAS002195

Cofactor

Binds 2 zinc ions per subunit By similarity. RuleBase RU003441 SAAS SAAS002195

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. RuleBase RU003441 SAAS SAAS002195

Subunit structure

Homodimer By similarity. SAAS SAAS002195

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily. RuleBase RU003441

Sequences

Sequence LengthMass (Da)Tools
Q5YTM1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: 57A3B0092EA24AA6

FASTA43746,011
        10         20         30         40         50         60 
MSGLLIKGAV LYGEGEPVDV FVDEGEIRQI GTDLGVVDAE IVEARGQVLL PGFVDLHTHL 

        70         80         90        100        110        120 
REPGREDTET IETGSAAAAL GGYTAVFAMA NTNPVADSVV VTDHVWRRGQ EVGLVDVHPV 

       130        140        150        160        170        180 
GAVTVGLAGK QLAEMGTMAA GVGGVRMFSD DGHCVYDPLI MRRALEYSNS LGVLIAQHAE 

       190        200        210        220        230        240 
EPRLTKGAVA HEGPTAARLG LAGWPRAAEE SIVARDALLA RDAGARVHIC HASTAGTVEL 

       250        260        270        280        290        300 
VKWAKAQGIS ITAEVTPHHL LLDDSRLETY DAVNKVNPPL REASDTAALR AALAEGIIDC 

       310        320        330        340        350        360 
VATDHAPHAE QDKCCEFAAA RPGMLGLETA LSIVVETMVR PGLLDWRGVA RVMSERPAEI 

       370        380        390        400        410        420 
VGLDDQGRPI AVGEPANLVL VDPDATWTVR ASELASISNN TPFEEMTFPA RVTMTLLRGR 

       430 
ITARAGRAAQ PQGAGGA

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References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006618 Genomic DNA. Translation: BAD58470.1.
RefSeqYP_119834.1. NC_006361.1.

3D structure databases

ProteinModelPortalQ5YTM1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3107023.
GenomeReviewsGene locus NFA_36220 in contig AP006618_GR.
KEGGnfa:nfa36220.
NMPDRfig|247156.1.peg.3535.
PATRIC22736860. VBINocFar94200_3666.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG724623.
OMACDVHPVG.
ProtClustDBPRK09357.

Family and domain databases

HAMAPMF_00220_B. PyrC_type2_B.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. PyrC_multi. 1 hit.
PROSITEPS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ5YTM1_NOCFA
AccessionPrimary (citable) accession number: Q5YTM1
Entry history
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: December 14, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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