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Q5YTI1

- MDH_NOCFA

UniProt

Q5YTI1 - MDH_NOCFA

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei97 – 971SubstrateUniRule annotation
Binding sitei103 – 1031SubstrateUniRule annotation
Binding sitei110 – 1101NADUniRule annotation
Binding sitei117 – 1171NADUniRule annotation
Binding sitei136 – 1361SubstrateUniRule annotation
Binding sitei167 – 1671SubstrateUniRule annotation
Active sitei192 – 1921Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi16 – 227NADUniRule annotation
Nucleotide bindingi134 – 1363NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-3712-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:NFA_36620
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 334334Malate dehydrogenasePRO_0000113383Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi247156.nfa36620.

Structurei

3D structure databases

ProteinModelPortaliQ5YTI1.
SMRiQ5YTI1. Positions 8-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0039.
KOiK00024.
OMAiVNDQAWL.
OrthoDBiEOG6PP9Q2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YTI1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTADRTAPV TVTVTGAAGQ IAYGLLFRIA SGAMLGPHTP IRLRLLEIPA
60 70 80 90 100
AVASLEGVAM ELEDGAFPLL DAIDISDDPW TGFAGANVAL LVGARPRTAG
110 120 130 140 150
MERADLLAAN GPIFTDQGQA INAVAADDVK VLVVGNPANT NAFIAMSNAP
160 170 180 190 200
DVPAERFTAM TRLDHNRAIA QLAKKTGAPA TEIHRIAVWG NHSATQYPDL
210 220 230 240 250
THATVAGRPA RELVDEQWLR EDFIPTVQQR GTAIIQARGA SSAASAASAA
260 270 280 290 300
IDHIHDWVLG TPAGEWTSMA VPSDGSYGVP DGLISSFPVT CADGAYRIVE
310 320 330
GLEVDAFSRE RIDASVAELT AEREAVVELG FAKG
Length:334
Mass (Da):34,910
Last modified:November 23, 2004 - v1
Checksum:iC79493FA1D8CCE8C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD58510.1.
RefSeqiYP_119874.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD58510; BAD58510; NFA_36620.
GeneIDi3111271.
KEGGinfa:nfa36620.
PATRICi22736946. VBINocFar94200_3709.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD58510.1 .
RefSeqi YP_119874.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YTI1.
SMRi Q5YTI1. Positions 8-331.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa36620.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD58510 ; BAD58510 ; NFA_36620 .
GeneIDi 3111271.
KEGGi nfa:nfa36620.
PATRICi 22736946. VBINocFar94200_3709.

Phylogenomic databases

eggNOGi COG0039.
KOi K00024.
OMAi VNDQAWL.
OrthoDBi EOG6PP9Q2.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-3712-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_01517. Malate_dehydrog_2.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23382. PTHR23382. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
PROSITEi PS00068. MDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiMDH_NOCFA
AccessioniPrimary (citable) accession number: Q5YTI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: November 23, 2004
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3