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Q5YTI1

- MDH_NOCFA

UniProt

Q5YTI1 - MDH_NOCFA

Protein

Malate dehydrogenase

Gene

mdh

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei97 – 971SubstrateUniRule annotation
    Binding sitei103 – 1031SubstrateUniRule annotation
    Binding sitei110 – 1101NADUniRule annotation
    Binding sitei117 – 1171NADUniRule annotation
    Binding sitei136 – 1361SubstrateUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation
    Active sitei192 – 1921Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi16 – 227NADUniRule annotation
    Nucleotide bindingi134 – 1363NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-3712-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:NFA_36620
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 334334Malate dehydrogenasePRO_0000113383Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi247156.nfa36620.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5YTI1.
    SMRiQ5YTI1. Positions 8-331.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    KOiK00024.
    OMAiVNDQAWL.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.
    PROSITEiPS00068. MDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5YTI1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTADRTAPV TVTVTGAAGQ IAYGLLFRIA SGAMLGPHTP IRLRLLEIPA    50
    AVASLEGVAM ELEDGAFPLL DAIDISDDPW TGFAGANVAL LVGARPRTAG 100
    MERADLLAAN GPIFTDQGQA INAVAADDVK VLVVGNPANT NAFIAMSNAP 150
    DVPAERFTAM TRLDHNRAIA QLAKKTGAPA TEIHRIAVWG NHSATQYPDL 200
    THATVAGRPA RELVDEQWLR EDFIPTVQQR GTAIIQARGA SSAASAASAA 250
    IDHIHDWVLG TPAGEWTSMA VPSDGSYGVP DGLISSFPVT CADGAYRIVE 300
    GLEVDAFSRE RIDASVAELT AEREAVVELG FAKG 334
    Length:334
    Mass (Da):34,910
    Last modified:November 23, 2004 - v1
    Checksum:iC79493FA1D8CCE8C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD58510.1.
    RefSeqiYP_119874.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD58510; BAD58510; NFA_36620.
    GeneIDi3111271.
    KEGGinfa:nfa36620.
    PATRICi22736946. VBINocFar94200_3709.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD58510.1 .
    RefSeqi YP_119874.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5YTI1.
    SMRi Q5YTI1. Positions 8-331.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa36620.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD58510 ; BAD58510 ; NFA_36620 .
    GeneIDi 3111271.
    KEGGi nfa:nfa36620.
    PATRICi 22736946. VBINocFar94200_3709.

    Phylogenomic databases

    eggNOGi COG0039.
    KOi K00024.
    OMAi VNDQAWL.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci NFAR247156:GJ9T-3712-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR001252. Malate_DH_AS.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    PROSITEi PS00068. MDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiMDH_NOCFA
    AccessioniPrimary (citable) accession number: Q5YTI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3