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Q5YTA5 (DCUP_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Uroporphyrinogen decarboxylase
Short name=UPD
Short name=URO-D
EC=4.1.1.37
Gene names
Name:hemE
Ordered Locus Names:NFA_37380
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin-containing compound biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_0000325668

Regions

Region35 – 395Substrate binding By similarity

Sites

Binding site841Substrate By similarity
Binding site1591Substrate By similarity
Binding site2141Substrate By similarity
Binding site3331Substrate By similarity
Site841Transition state stabilizer By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5YTA5 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: D9B25A13AD28AB69

FASTA35437,546
        10         20         30         40         50         60 
MAGMSTHTRR RLTDAPFLAA ATGATPSRRP VWFMRQAGRS LPEYRELRAG IGMLESCFDP 

        70         80         90        100        110        120 
ELVCEITMQP IRRHGVDAAI LFSDIVVPLK AAGIDLDIVA GVGPVVAAPV RSVADVRALP 

       130        140        150        160        170        180 
RLRPEEVGAV VEGVRLLVDA LGQTPLIGFA GAPFTLASYL VEGGPSKHHE RTKAMMYADP 

       190        200        210        220        230        240 
KTWHELLGVL TDITIAFLRA QLDAGVDAVQ LFDSWAGALS PADYRAFVLP HSERVFTEIA 

       250        260        270        280        290        300 
DAGVPRIHFG VGTGELLGAM GEAGADVVGV DWRVSLTEAA RRVGPGKALQ GNLDPAVLFA 

       310        320        330        340        350 
GPRAVEAHAR RIAEEADRAL ALGAAGHIFN LGHGVLPDTD PGVLTALVEL VHEL

« Hide

References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006618 Genomic DNA. Translation: BAD58586.1.
RefSeqYP_119950.1. NC_006361.1.

3D structure databases

HSSPHSSP built from PDB template 1R3S based on UniProtKB P06132.
ProteinModelPortalQ5YTA5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3109561.
GenomeReviewsGene locus NFA_37380 in contig AP006618_GR.
KEGGnfa:nfa37380.
PATRIC22737108. VBINocFar94200_3786.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628392.
OMAPRIHFGV.
ProtClustDBPRK00115.

Enzyme and pathway databases

BioCycNFAR247156:NFA37380-MONOMER.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
KOK01599.
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. HemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCUP_NOCFA
AccessionPrimary (citable) accession number: Q5YTA5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 23, 2004
Last modified: January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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