Reviewed, UniProtKB/Swiss-Prot Q5YT53 (AHPD_NOCFA)

Names and origin

Protein names

Recommended name:
    Alkyl hydroperoxide reductase ahpD
    EC=1.11.1.15
Alternative name(s):
    Alkylhydroperoxidase ahpD

Gene names

Name:	ahpD
Ordered Locus Names:	NFA_37900

Organism

Nocardia farcinica [Complete proteome] [HAMAP]

Taxonomic identifier

37329 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	179 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the ahpC active site cysteine residues and for the regeneration of the ahpC enzyme activity By similarity.
Catalytic activity	2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. HAMAP MF_01676
Subunit structure	Homotrimer By similarity.
Sequence similarities	Belongs to the ahpD family.

Ontologies

Keywords
Domain	Redox-active center
Molecular function	Antioxidant Oxidoreductase Peroxidase
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	alkyl hydroperoxide reductase activity Inferred from electronic annotation. Source: HAMAP peroxiredoxin activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 179	179	Alkyl hydroperoxide reductase ahpD HAMAP MF_01676		PRO_0000359502
Sites
	Active site	130	1	Proton donor By similarity
	Active site	133	1	Cysteine sulfenic acid (-SOH) intermediate By similarity
Amino acid modifications
	Disulfide bond	130 ↔ 133		Alternate By similarity
	Disulfide bond	133		Interchain (with ahpC); in linked form By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5YT53-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 78EF0FFEA2929936	FASTA	179	18,986
	10 20 30 40 50 60 MSIENLKNSL PEYAKDLKLN LSSIARSTVL NEQQLWGTLL ASAAATRSAT TLREIAEEAA 70 80 90 100 110 120 DVLSAEAYNA ALGAASIMGM NNVFYRGKAF LGGRYDDLRA GLRMQIIGNP GVDKADFELW 130 140 150 160 170 SFAVSSINGC AHCLEAHEHT LREAGVSREV IFESLRVAAI VAGVGQAVQS TEALAAAAV

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006618 Genomic DNA. Translation: BAD58638.1.
RefSeq	YP_120002.1.
3D structure databases
SMR	Q5YT53. Positions 2-175.
ModBase	Search...
Protein family/group databases
PeroxiBase	4583. NfaAhpD.
Genome annotation databases
GeneID	3109919.
GenomeReviews	Gene locus NFA_37900 in contig AP006618_GR.
KEGG	nfa:nfa37900.
NMPDR	fig|247156.1.peg.3691.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5YT53.
OMA	MAMNNVY.
Enzyme and pathway databases
BioCyc	NFAR247156:NFA37900-MON.
Family and domain databases
HAMAP	MF_01676. [Tree]
InterPro	IPR004674. AhpD. IPR004675. AhpD_core. IPR003779. CMD. [Graphical view]
Pfam	PF02627. CMD. 1 hit. [Graphical view]
TIGRFAMs	TIGR00777. ahpD. 1 hit. TIGR00778. ahpD_dom. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AHPD_NOCFA

Accession

Primary (citable) accession number: Q5YT53

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	November 23, 2004
Last modified:	November 3, 2009
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)