Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q5YSV6

- PNP_NOCFA

UniProt

Q5YSV6 - PNP_NOCFA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Polyribonucleotide nucleotidyltransferase

Gene

pnp

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi541 – 5411MagnesiumUniRule annotation
Metal bindingi547 – 5471MagnesiumUniRule annotation

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-3941-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferaseUniRule annotation (EC:2.7.7.8UniRule annotation)
Alternative name(s):
Polynucleotide phosphorylaseUniRule annotation
Short name:
PNPaseUniRule annotation
Gene namesi
Name:pnpUniRule annotation
Ordered Locus Names:NFA_38870
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Polyribonucleotide nucleotidyltransferasePRO_0000329740Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa38870.

Structurei

3D structure databases

ProteinModelPortaliQ5YSV6.
SMRiQ5YSV6. Positions 23-741.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini607 – 66660KHUniRule annotationAdd
BLAST
Domaini678 – 74770S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the polyribonucleotide nucleotidyltransferase family.UniRule annotation
Contains 1 KH domain.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YSV6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQTSERKSS AVEVEPGVFE SVALIDNGSY GTRTVRFETG RLARQAAGSV
60 70 80 90 100
VAYLDDETML LSATTAGKTP KDQFDFFPLT VDVEERMYAA GRIPGSFFRR
110 120 130 140 150
EGRPSTDAIL TCRLIDRPLR PSFVDGLRNE VQVVVTVLSL DPKDLYDVVA
160 170 180 190 200
INAASASTQI AGLPFSGPVG GVRVALIPDQ GANSAGGGQW VAFPTVEQLE
210 220 230 240 250
GAVFDMVVAG RVVESGDVAI MMVEAEATEK VIELVEGGAQ APTEAVVAEG
260 270 280 290 300
LEAAKPFIAR LCRAQQDLAE LAAKPTEEFP LFPPYGPDVY EAVEGAAEAE
310 320 330 340 350
LGEALSIAGK QEREEKIDEI KLAVLDRLAE QFAGREKELG AAFRSVTKKL
360 370 380 390 400
VRQRILTDGF RIDGRGLADI RALSAEVAVV PRAHGSALFE RGETQILGVT
410 420 430 440 450
TLDMVKMAQQ VDSLGPETSK RYMHHYNFPP FSTGETGRVG SPKRREIGHG
460 470 480 490 500
ALAERALIPV LPSQEDFPYA IRQVSEALGS NGSTSMGSVC ASTLSLLNAG
510 520 530 540 550
VPLKAPVAGI AMGLVSDTVT NDKGEQEVRY VALTDILGAE DAFGDMDFKV
560 570 580 590 600
AGTREFVTAL QLDTKLDGIP SQVLAGALSQ AHDARTTILD VMAEAIATPD
610 620 630 640 650
EMSPYAPRVT AIKIPVDKIG EVIGPKGKVI NQITEDTGAN ISIEDDGTVF
660 670 680 690 700
VGATDGPSAQ AAIDAINAIA NPQLPKVGER FLGTVVKTTA FGAFVSLLPG
710 720 730 740 750
RDGLVHISKL GNGKRVAKVE DVVNVGDKLR VEIADIDNRG KISLVPVDEN
760
ADEPAADAVD AGTE
Length:764
Mass (Da):80,876
Last modified:November 23, 2004 - v1
Checksum:iCC9F5CEAE243A96B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD58735.1.
RefSeqiWP_011210420.1. NC_006361.1.
YP_120099.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD58735; BAD58735; NFA_38870.
GeneIDi3111377.
KEGGinfa:nfa38870.
PATRICi22737402. VBINocFar94200_3934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD58735.1 .
RefSeqi WP_011210420.1. NC_006361.1.
YP_120099.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YSV6.
SMRi Q5YSV6. Positions 23-741.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa38870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD58735 ; BAD58735 ; NFA_38870 .
GeneIDi 3111377.
KEGGi nfa:nfa38870.
PATRICi 22737402. VBINocFar94200_3934.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-3941-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. S1_dom.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiPNP_NOCFA
AccessioniPrimary (citable) accession number: Q5YSV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 23, 2004
Last modified: November 26, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3