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Q5YSV6

- PNP_NOCFA

UniProt

Q5YSV6 - PNP_NOCFA

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, NFA_38870
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi541 – 5411Magnesium By similarity
Metal bindingi547 – 5471Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-3941-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:NFA_38870
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 764764Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329740Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa38870.

Structurei

3D structure databases

ProteinModelPortaliQ5YSV6.
SMRiQ5YSV6. Positions 23-741.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini607 – 66660KH
Add
BLAST
Domaini678 – 74770S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
KOiK00962.
OMAiTIAGKQD.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YSV6-1 [UniParc]FASTAAdd to Basket

« Hide

MTQTSERKSS AVEVEPGVFE SVALIDNGSY GTRTVRFETG RLARQAAGSV    50
VAYLDDETML LSATTAGKTP KDQFDFFPLT VDVEERMYAA GRIPGSFFRR 100
EGRPSTDAIL TCRLIDRPLR PSFVDGLRNE VQVVVTVLSL DPKDLYDVVA 150
INAASASTQI AGLPFSGPVG GVRVALIPDQ GANSAGGGQW VAFPTVEQLE 200
GAVFDMVVAG RVVESGDVAI MMVEAEATEK VIELVEGGAQ APTEAVVAEG 250
LEAAKPFIAR LCRAQQDLAE LAAKPTEEFP LFPPYGPDVY EAVEGAAEAE 300
LGEALSIAGK QEREEKIDEI KLAVLDRLAE QFAGREKELG AAFRSVTKKL 350
VRQRILTDGF RIDGRGLADI RALSAEVAVV PRAHGSALFE RGETQILGVT 400
TLDMVKMAQQ VDSLGPETSK RYMHHYNFPP FSTGETGRVG SPKRREIGHG 450
ALAERALIPV LPSQEDFPYA IRQVSEALGS NGSTSMGSVC ASTLSLLNAG 500
VPLKAPVAGI AMGLVSDTVT NDKGEQEVRY VALTDILGAE DAFGDMDFKV 550
AGTREFVTAL QLDTKLDGIP SQVLAGALSQ AHDARTTILD VMAEAIATPD 600
EMSPYAPRVT AIKIPVDKIG EVIGPKGKVI NQITEDTGAN ISIEDDGTVF 650
VGATDGPSAQ AAIDAINAIA NPQLPKVGER FLGTVVKTTA FGAFVSLLPG 700
RDGLVHISKL GNGKRVAKVE DVVNVGDKLR VEIADIDNRG KISLVPVDEN 750
ADEPAADAVD AGTE 764
Length:764
Mass (Da):80,876
Last modified:November 23, 2004 - v1
Checksum:iCC9F5CEAE243A96B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD58735.1.
RefSeqiYP_120099.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD58735; BAD58735; NFA_38870.
GeneIDi3111377.
KEGGinfa:nfa38870.
PATRICi22737402. VBINocFar94200_3934.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD58735.1 .
RefSeqi YP_120099.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YSV6.
SMRi Q5YSV6. Positions 23-741.
ModBasei Search...

Protein-protein interaction databases

STRINGi 247156.nfa38870.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD58735 ; BAD58735 ; NFA_38870 .
GeneIDi 3111377.
KEGGi nfa:nfa38870.
PATRICi 22737402. VBINocFar94200_3934.

Phylogenomic databases

eggNOGi COG1185.
KOi K00962.
OMAi TIAGKQD.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-3941-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiPNP_NOCFA
AccessioniPrimary (citable) accession number: Q5YSV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: November 23, 2004
Last modified: May 14, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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