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Q5YRP8

- COX1A_NOCFA

UniProt

Q5YRP8 - COX1A_NOCFA

Protein

Probable cytochrome c oxidase subunit 1-alpha

Gene

ctaD1

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B By similarity.By similarity

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Cofactori

    Binds 1 copper B per subunit.By similarity
    Binds 2 heme groups per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi87 – 871Iron (heme A axial ligand)By similarity
    Metal bindingi265 – 2651Copper BBy similarity
    Metal bindingi269 – 2691Copper BBy similarity
    Metal bindingi314 – 3141Copper BBy similarity
    Metal bindingi315 – 3151Copper BBy similarity
    Metal bindingi398 – 3981Iron (heme A3 axial ligand)By similarity
    Metal bindingi400 – 4001Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. cytochrome-c oxidase activity Source: UniProtKB-EC
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. electron transport chain Source: InterPro
    3. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-4354-MONOMER.
    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome aa3 subunit 1-alpha
    Cytochrome c oxidase polypeptide I-alpha
    Gene namesi
    Name:ctaD1
    Ordered Locus Names:NFA_42940
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 581581Probable cytochrome c oxidase subunit 1-alphaPRO_0000183445Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Interactioni

    Subunit structurei

    Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

    Protein-protein interaction databases

    STRINGi247156.nfa42940.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5YRP8.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei128 – 14821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei214 – 23421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei360 – 38021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei399 – 41921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei434 – 45421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei477 – 49721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0843.
    KOiK02274.
    OMAiINGEFIW.
    OrthoDBiEOG6B35XR.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5YRP8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTAVEPRPVP QLEATRPYPA RTGPKGSFLY KMVTTTDPKV LGTMYLVTAM    50
    SFFMIGGLMA LLMRGELARP GLQFLSPEQF NQLFTMHGTI MLLFYATAIV 100
    FGFANIILPL QIGAPDVAFP RLNAFSYWLY AFGATMATAG FITPGGAADF 150
    GWTAYVPLTD ILHSPGVGTD LWILGLAVSG LGTILGGVNM LTTVVCLRAP 200
    GMTMFRMPIF TWNIAVTSVL VLLAFPLLTA ALFGLAYDRH LGGHIYDPAT 250
    GGILLYQHLF WFFGHPEVYI IALPFFGIVS EIFPVFSRKP IFGYTTLVYA 300
    TLGIAALSIA VWAHHMYATG AVLLPYFSFM TFLIAVPTGV KFFNWIGTMW 350
    RGQLTFESPM LWSLGFLVTF LFGGLSGVIL ASPPLDFHVT DSYFVVAHFH 400
    YVLFGTIVFA TFAGIYFWFP KITGRMVDER LAKWHFWATF VGFHTTFLVQ 450
    HWLGAEGMPR RYADYLPSDG FTTLNTISTI GAFVLGASML PFIWNIFKSY 500
    RYGEVVTVDD PWGYGNSLEW ATTCPPPRHN FYELPRIRSE RPAFELHYPH 550
    MIERMRAEAH VGWGSGKHGT PQDDDALLAK K 581
    Length:581
    Mass (Da):64,744
    Last modified:November 23, 2004 - v1
    Checksum:i80C88D7D9C8C2516
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD59143.1.
    RefSeqiWP_011210828.1. NC_006361.1.
    YP_120507.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD59143; BAD59143; NFA_42940.
    GeneIDi3106270.
    KEGGinfa:nfa42940.
    PATRICi22738138. VBINocFar94200_4296.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD59143.1 .
    RefSeqi WP_011210828.1. NC_006361.1.
    YP_120507.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5YRP8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa42940.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD59143 ; BAD59143 ; NFA_42940 .
    GeneIDi 3106270.
    KEGGi nfa:nfa42940.
    PATRICi 22738138. VBINocFar94200_4296.

    Phylogenomic databases

    eggNOGi COG0843.
    KOi K02274.
    OMAi INGEFIW.
    OrthoDBi EOG6B35XR.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci NFAR247156:GJ9T-4354-MONOMER.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    IPR014241. Cyt_c_oxidase_su1_bac.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    TIGRFAMsi TIGR02891. CtaD_CoxA. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiCOX1A_NOCFA
    AccessioniPrimary (citable) accession number: Q5YRP8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3