Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable cytochrome c oxidase subunit 1-alpha

Gene

ctaD1

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).By similarity

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Protein has several cofactor binding sites:
  • Cu2+By similarityNote: Binds 1 copper B ion per subunit.By similarity
  • hemeBy similarityNote: Binds 2 heme groups per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi87 – 871Iron (heme A axial ligand)By similarity
Metal bindingi265 – 2651Copper BBy similarity
Metal bindingi269 – 2691Copper BBy similarity
Metal bindingi314 – 3141Copper BBy similarity
Metal bindingi315 – 3151Copper BBy similarity
Metal bindingi398 – 3981Iron (heme A3 axial ligand)By similarity
Metal bindingi400 – 4001Iron (heme A axial ligand)By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. electron transport chain Source: InterPro
  3. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-4354-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cytochrome c oxidase subunit 1-alpha (EC:1.9.3.1)
Alternative name(s):
Cytochrome aa3 subunit 1-alpha
Cytochrome c oxidase polypeptide I-alpha
Gene namesi
Name:ctaD1
Ordered Locus Names:NFA_42940
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820 Componenti: Chromosome

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei90 – 11021HelicalSequence AnalysisAdd
BLAST
Transmembranei128 – 14821HelicalSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Transmembranei214 – 23421HelicalSequence AnalysisAdd
BLAST
Transmembranei259 – 27921HelicalSequence AnalysisAdd
BLAST
Transmembranei291 – 31121HelicalSequence AnalysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence AnalysisAdd
BLAST
Transmembranei360 – 38021HelicalSequence AnalysisAdd
BLAST
Transmembranei399 – 41921HelicalSequence AnalysisAdd
BLAST
Transmembranei434 – 45421HelicalSequence AnalysisAdd
BLAST
Transmembranei477 – 49721HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 581581Probable cytochrome c oxidase subunit 1-alphaPRO_0000183445Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki265 ↔ 2691'-histidyl-3'-tyrosine (His-Tyr)By similarity

Interactioni

Subunit structurei

Associates with subunits II, III and IV to form cytochrome c oxidase.By similarity

Protein-protein interaction databases

STRINGi247156.nfa42940.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0843.
KOiK02274.
OMAiAAELFFM.
OrthoDBiEOG6B35XR.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YRP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAVEPRPVP QLEATRPYPA RTGPKGSFLY KMVTTTDPKV LGTMYLVTAM
60 70 80 90 100
SFFMIGGLMA LLMRGELARP GLQFLSPEQF NQLFTMHGTI MLLFYATAIV
110 120 130 140 150
FGFANIILPL QIGAPDVAFP RLNAFSYWLY AFGATMATAG FITPGGAADF
160 170 180 190 200
GWTAYVPLTD ILHSPGVGTD LWILGLAVSG LGTILGGVNM LTTVVCLRAP
210 220 230 240 250
GMTMFRMPIF TWNIAVTSVL VLLAFPLLTA ALFGLAYDRH LGGHIYDPAT
260 270 280 290 300
GGILLYQHLF WFFGHPEVYI IALPFFGIVS EIFPVFSRKP IFGYTTLVYA
310 320 330 340 350
TLGIAALSIA VWAHHMYATG AVLLPYFSFM TFLIAVPTGV KFFNWIGTMW
360 370 380 390 400
RGQLTFESPM LWSLGFLVTF LFGGLSGVIL ASPPLDFHVT DSYFVVAHFH
410 420 430 440 450
YVLFGTIVFA TFAGIYFWFP KITGRMVDER LAKWHFWATF VGFHTTFLVQ
460 470 480 490 500
HWLGAEGMPR RYADYLPSDG FTTLNTISTI GAFVLGASML PFIWNIFKSY
510 520 530 540 550
RYGEVVTVDD PWGYGNSLEW ATTCPPPRHN FYELPRIRSE RPAFELHYPH
560 570 580
MIERMRAEAH VGWGSGKHGT PQDDDALLAK K
Length:581
Mass (Da):64,744
Last modified:November 22, 2004 - v1
Checksum:i80C88D7D9C8C2516
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD59143.1.
RefSeqiYP_120507.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD59143; BAD59143; NFA_42940.
KEGGinfa:nfa42940.
PATRICi22738138. VBINocFar94200_4296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD59143.1.
RefSeqiYP_120507.1. NC_006361.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi247156.nfa42940.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAD59143; BAD59143; NFA_42940.
KEGGinfa:nfa42940.
PATRICi22738138. VBINocFar94200_4296.

Phylogenomic databases

eggNOGiCOG0843.
KOiK02274.
OMAiAAELFFM.
OrthoDBiEOG6B35XR.

Enzyme and pathway databases

UniPathwayiUPA00705.
BioCyciNFAR247156:GJ9T-4354-MONOMER.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiCOX1A_NOCFA
AccessioniPrimary (citable) accession number: Q5YRP8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 25, 2005
Last sequence update: November 22, 2004
Last modified: March 31, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.