ID   COAA_NOCFA              Reviewed;         310 AA.
AC   Q5YQ72;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   16-JUN-2009, entry version 32.
DE   RecName: Full=Pantothenate kinase;
DE            EC=2.7.1.33;
DE   AltName: Full=Pantothenic acid kinase;
GN   Name=coaA; OrderedLocusNames=NFA_48170;
OS   Nocardia farcinica.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Nocardiaceae; Nocardia.
OX   NCBI_TaxID=37329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IFM 10152;
RX   PubMed=15466710; DOI=10.1073/pnas.0406410101;
RA   Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K.,
RA   Shiba T., Hattori M.;
RT   "The complete genomic sequence of Nocardia farcinica IFM 10152.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004).
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'-
CC       phosphopantothenate.
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme
CC       A from pantothenate: step 1/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the prokaryotic pantothenate kinase family.
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DR   EMBL; AP006618; BAD59669.1; -; Genomic_DNA.
DR   RefSeq; YP_121033.1; -.
DR   SMR; Q5YQ72; 5-310.
DR   GeneID; 3109846; -.
DR   GenomeReviews; AP006618_GR; NFA_48170.
DR   KEGG; nfa:nfa48170; -.
DR   NMPDR; fig|247156.1.peg.4632; -.
DR   HOGENOM; Q5YQ72; -.
DR   OMA; Q5YQ72; PKVDLIT.
DR   BioCyc; NFAR247156:NFA48170-MON; -.
DR   BRENDA; 2.7.1.33; 290697.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004594; F:pantothenate kinase activity; IEA:HAMAP.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00215; -; 1.
DR   InterPro; IPR004566; PanK_bact.
DR   PANTHER; PTHR10285:SF7; PanK_bact; 1.
DR   PIRSF; PIRSF000545; Pantothenate_kin; 1.
DR   TIGRFAMs; TIGR00554; panK_bact; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    310       Pantothenate kinase.
FT                                /FTId=PRO_1000043237.
FT   NP_BIND      95    102       ATP (Potential).
SQ   SEQUENCE   310 AA;  35436 MW;  7D299941B2DD901F CRC64;
     MARMSEPSPY VEFDRKQWRT LRKSTPLVLT EEELIGLRGL GEQIDLEEVA EVYLPLARLI
     HLQVAARQRL FAATATFLGE KHPDRQVPFV IGVAGSVAVG KSTTARVLQA LLARWEHHPR
     VDLVTTDGFL YPTAELTRRG IMHRKGFPES YDRRKLLRFV TEVKSGAEEV CAPVYSHISY
     DIVPGKLHCV RQPDILIVEG LNVLQTGPRL MVSDLFDFSI YVDARIEDIE KWYVQRFLAL
     RKTAFADPDA HFHHYASLTD EQATLAAQEI WNSTNRPNLV ENILPTRPRA TLVLRKDADH
     SINRLRLRKL
//