Reviewed, UniProtKB/Swiss-Prot Q5YQ72 (COAA_NOCFA)

Names and origin

Protein names

Recommended name:
    Pantothenate kinase
    EC=2.7.1.33
Alternative name(s):
    Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	NFA_48170

Organism

Nocardia farcinica [Complete proteome] [HAMAP]

Taxonomic identifier

37329 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	310 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme A from pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP pantothenate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 310	310	Pantothenate kinase HAMAP MF_00215		PRO_1000043237
Regions
	Nucleotide binding	95 – 102	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q5YQ72-1 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 7D299941B2DD901F	FASTA	310	35,436
	10 20 30 40 50 60 MARMSEPSPY VEFDRKQWRT LRKSTPLVLT EEELIGLRGL GEQIDLEEVA EVYLPLARLI 70 80 90 100 110 120 HLQVAARQRL FAATATFLGE KHPDRQVPFV IGVAGSVAVG KSTTARVLQA LLARWEHHPR 130 140 150 160 170 180 VDLVTTDGFL YPTAELTRRG IMHRKGFPES YDRRKLLRFV TEVKSGAEEV CAPVYSHISY 190 200 210 220 230 240 DIVPGKLHCV RQPDILIVEG LNVLQTGPRL MVSDLFDFSI YVDARIEDIE KWYVQRFLAL 250 260 270 280 290 300 RKTAFADPDA HFHHYASLTD EQATLAAQEI WNSTNRPNLV ENILPTRPRA TLVLRKDADH 310 SINRLRLRKL

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AP006618 Genomic DNA. Translation: BAD59669.1.
RefSeq	YP_121033.1.
3D structure databases
SMR	Q5YQ72. Positions 5-310.
ModBase	Search...
Genome annotation databases
GeneID	3109846.
GenomeReviews	Gene locus NFA_48170 in contig AP006618_GR.
KEGG	nfa:nfa48170.
NMPDR	fig|247156.1.peg.4632.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q5YQ72.
OMA	Q5YQ72. PKVDLIT.
Enzyme and pathway databases
BioCyc	NFAR247156:NFA48170-MON.
BRENDA	2.7.1.33. 290697.
Family and domain databases
HAMAP	MF_00215. [Tree]
InterPro	IPR004566. PanK_bact. [Graphical view]
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. panK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_NOCFA

Accession

Primary (citable) accession number: Q5YQ72

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	November 23, 2004
Last modified:	June 16, 2009
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)