Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q5YPP1 (G6PI_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:pgi
Ordered Locus Names:NFA_49980
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia

Protein attributes

Sequence length551 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

glycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 551551Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180696

Sites

Active site3591Proton donor By similarity
Active site3901 By similarity
Active site5161 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q5YPP1 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: F22568B0F195B6EF

FASTA55159,471
        10         20         30         40         50         60 
MSTLADVSSD ITASAAWRKL HDHHGALAQR HLREIFAEDP ERGRELTLQV ADLHIDYSKH 

        70         80         90        100        110        120 
RATRETLQLL VELAREAGVE AHRDAMFAGE HINTSEDRAV GHVALRLPAG RTMTIDGADA 

       130        140        150        160        170        180 
GAQVHEVLRR MGEFTDALRS GQWRGATGER IETVVNIGIG GSDLGPVMVH QALRHYADAG 

       190        200        210        220        230        240 
ITARFVSNVD PADLVAELTG LNPATTLFIV ASKTFSTLET LTNATAARRW LVAALGEDAV 

       250        260        270        280        290        300 
AKHFVAVSTN AERVSAFGID TANMFGFWDW VGGRYSVDSA IGLSVMATIG KERFAEFLAG 

       310        320        330        340        350        360 
MHAVDTHFAT APLEANAPVL LGLLGIWYAN FFGAESRAVL PYSNDLARFP AYLQQLTMES 

       370        380        390        400        410        420 
NGKSVRADGT PVTTATGEIF WGEPGTNGQH AFYQLLHQGT RLIPADFIGF ARPTDDLPTA 

       430        440        450        460        470        480 
DGTGSMHDVL MSNLFAQTKV LAFGKTAEEI AAEGTAPNLV PHKVMPGNRP STTILAPQLT 

       490        500        510        520        530        540 
PAVVGQLIAL YEHQVFVEGV IWGIDSFDQW GVELGKQQAL ALAALLTAAE DPAPQDDSST 

       550 
DALIRWYRAH R 

« Hide

References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP006618 Genomic DNA. Translation: BAD59850.1.
RefSeqYP_121214.1. NC_006361.1.

3D structure databases

ProteinModelPortalQ5YPP1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING247156.nfa49980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAD59850; BAD59850; NFA_49980.
GeneID3111365.
KEGGnfa:nfa49980.
PATRIC22739577. VBINocFar94200_5011.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0166.
KOK01810.
OMAEWTELED.
OrthoDBEOG64R61J.
ProtClustDBPRK00179.

Enzyme and pathway databases

BioCycNFAR247156:GJ9T-5066-MONOMER.
UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_NOCFA
AccessionPrimary (citable) accession number: Q5YPP1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: November 23, 2004
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways