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Protein

Elongation factor Tu

Gene

tuf

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi19 – 26GTPUniRule annotation8
Nucleotide bindingi83 – 87GTPUniRule annotation5
Nucleotide bindingi138 – 141GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Synonyms:tufB
Ordered Locus Names:NFA_50750
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000006820 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003374481 – 396Elongation factor TuAdd BLAST396

Proteomic databases

PRIDEiQ5YPG4.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi247156.nfa50750.

Structurei

3D structure databases

ProteinModelPortaliQ5YPG4.
SMRiQ5YPG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 205tr-type GAdd BLAST196

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 26G1By similarity8
Regioni62 – 66G2By similarity5
Regioni83 – 86G3By similarity4
Regioni138 – 141G4By similarity4
Regioni175 – 177G5By similarity3

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CGV. Bacteria.
COG0050. LUCA.
OMAiYGHIDCP.
OrthoDBiPOG091H00LA.

Family and domain databases

CDDicd03697. EFTU_II. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B. 1 hit.
InterProiView protein in InterPro
IPR004161. EFTu-like_2.
IPR033720. EFTU_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel_sf.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
PfamiView protein in Pfam
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q5YPG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKAKFERTK PHVNIGTIGH VDHGKTTLTA AITKVLADKY PDLNQSFAFD
60 70 80 90 100
QIDKAPEEKA RGITINISHV EYQTEKRHYA HVDAPGHADY IKNMITGAAQ
110 120 130 140 150
MDGAILVVAA TDGPMPQTRE HVLLARQVGV PYILVALNKA DMVDDEEILE
160 170 180 190 200
LVEMEVRELL AAQEFDEEAP VVRVSGLKAL EGDPKWVKSV EDLMDAVDES
210 220 230 240 250
IPDPVRETDK PFLMPIEDVF TITGRGTVVT GRVERGIINV NEEVEITGIR
260 270 280 290 300
PETTKTTVTG IEMFRKLLDQ GQAGDNVGLL IRGIKREDVE RGQVVIKPGT
310 320 330 340 350
TTPHTEFEGQ AYILSKDEGG RHTPFFNNYR PQFYFRTTDV TGVVTLPEGT
360 370 380 390
EMVMPGDNTE MSVKLIQPVA MEEGLRFAIR EGGRTVGAGR VTKIIK
Length:396
Mass (Da):43,769
Last modified:May 20, 2008 - v2
Checksum:i0EF9BD2E3060CCAF
GO

Sequence cautioni

The sequence BAD59927 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA. Translation: BAD59927.1. Different initiation.
RefSeqiWP_011211609.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD59927; BAD59927; NFA_50750.
KEGGinfa:NFA_50750.

Similar proteinsi

Entry informationi

Entry nameiEFTU_NOCFA
AccessioniPrimary (citable) accession number: Q5YPG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 22, 2017
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome