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Q5YP79

- GSA_NOCFA

UniProt

Q5YP79 - GSA_NOCFA

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Protein
Glutamate-1-semialdehyde 2,1-aminomutase
Gene
hemL, NFA_51600
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. glutamate-1-semialdehyde 2,1-aminomutase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
  3. transaminase activity Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Porphyrin biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-5231-MONOMER.
UniPathwayiUPA00251; UER00317.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase (EC:5.4.3.8)
Short name:
GSA
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name:
GSA-AT
Gene namesi
Name:hemL
Ordered Locus Names:NFA_51600
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation
PRO_0000243590Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi247156.nfa51600.

Structurei

3D structure databases

ProteinModelPortaliQ5YP79.
SMRiQ5YP79. Positions 14-429.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0001.
KOiK01845.
OMAiTVIGHAN.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_00375. HemL_aminotrans_3.
InterProiIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR00713. hemL. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YP79-1 [UniParc]FASTAAdd to Basket

« Hide

MSASPRATHA SAAASARLFD RAAQVIPGGV NSPVRAFRSV GGTPRFIASA    50
DGYTLTDADG NEYVDLVCSW GPMILGHAHP AVVDAVRRAA TGGLSFGAPT 100
EAEVELAEHI VARVAPVDRV RLVNSGTEAT MSAVRLARGF TGRTKIIKFA 150
GCYHGHVDAL LADAGSGVAT LGLPTSPGVT GAQAADTIVL PYNDLDAVAA 200
AFEANPGEIA CVITEAAAGN MGAVAPLPGF NAGLRELTEN HGALLIMDEV 250
MTGFRVSRSG WYGREGVAGD LYTFGKVMSG GLPAAAFGGR AEVMNQLAPL 300
GPVYQAGTLS GNPVAVAAGL ATLRAADDAV YAALDRNAER LGGLLTEALT 350
AAGVEHQVQF AGNMVSVFFS DRPVTDYATA KASQTWRFPA FFHALLDGGV 400
YAPPSAFEAW FVSAALDEDA FARIAAALPA AARAAAAATP EGSRA 445
Length:445
Mass (Da):45,484
Last modified:November 23, 2004 - v1
Checksum:i6B38484F7BE71817
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD60012.1.
RefSeqiWP_011211694.1. NC_006361.1.
YP_121376.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD60012; BAD60012; NFA_51600.
GeneIDi3109563.
KEGGinfa:nfa51600.
PATRICi22739905. VBINocFar94200_5171.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD60012.1 .
RefSeqi WP_011211694.1. NC_006361.1.
YP_121376.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YP79.
SMRi Q5YP79. Positions 14-429.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa51600.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD60012 ; BAD60012 ; NFA_51600 .
GeneIDi 3109563.
KEGGi nfa:nfa51600.
PATRICi 22739905. VBINocFar94200_5171.

Phylogenomic databases

eggNOGi COG0001.
KOi K01845.
OMAi TVIGHAN.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00317 .
BioCyci NFAR247156:GJ9T-5231-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_00375. HemL_aminotrans_3.
InterProi IPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR00713. hemL. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiGSA_NOCFA
AccessioniPrimary (citable) accession number: Q5YP79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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