Q5YP73 (Q5YP73_NOCFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Delta-aminolevulinic acid dehydratase RuleBase RU000515
EC=4.2.1.24 RuleBase RU000515

Gene names

Name:	hemB EMBL BAD60018.1
Ordered Locus Names:	NFA_51660

Organism

Nocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]

Taxonomic identifier

247156 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	325 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 5-aminolevulinate = porphobilinogen + 2 H2O. RuleBase RU000515
Subunit structure	Homooctamer By similarity. RuleBase RU000515
Sequence similarities	Belongs to the ALADH family. RuleBase RU004161

Ontologies

Keywords
Biological process	Porphyrin biosynthesis RuleBase RU000515
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-5
Molecular function	Lyase RuleBase RU000515
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	198	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	250	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	235	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	208	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	219	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	276	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	315	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q5YP73 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 18B9D0D600D03ACB	FASTA	325	35,021
	10 20 30 40 50 60 MTGMDRPRRL RRTPALRRLV AETTVEPRHL VLPMFVADGL DEPREIGSMP GVQQHSMDSL 70 80 90 100 110 120 RKAATEAVSA GVGGLMLFGV PRPEDKDPAG SQASDPDGIL NRGLRALAEE VGDATVIMAD 130 140 150 160 170 180 TCLDEFTDHG HCGVLAADGH VDNDATLHRY VDMALAQAEA GADLLGTSGM MDGQVGAIRR 190 200 210 220 230 240 GLDAVGRTDT GILAYAAKYS SAFYGPFREA VSSSLQGDRR TYQQDPANRR ESMHELDLDL 250 260 270 280 290 300 AEGADIVMVK PAMSYLDILR EVADRSPVPV AAYQISGEYS MITAAAERGW IDRRAAVLES 310 320 LVGIRRAGAD IVLTYWATEA AHWLS

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006618 Genomic DNA. Translation: BAD60018.1.
RefSeq	YP_121382.1. NC_006361.1.
3D structure databases
ProteinModelPortal	Q5YP73.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3109558.
GenomeReviews	Gene locus NFA_51660 in contig AP006618_GR.
KEGG	nfa:nfa51660.
NMPDR	fig|247156.1.peg.4964.
PATRIC	22739919. VBINocFar94200_5178.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	FTSHGHD.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q5YP73_NOCFA

Accession

Primary (citable) accession number: Q5YP73

Entry history

Integrated into UniProtKB/TrEMBL:	November 23, 2004
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)