Q5YP50 (GPMA_NOCFA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Short name=BPG-dependent PGAM
Short name=PGAM
Short name=Phosphoglyceromutase
Short name=dPGM
EC=5.4.2.1

Gene names

Name:	gpmA
Ordered Locus Names:	NFA_51890

Organism

Nocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]

Taxonomic identifier

247156 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length	245 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphoglycerate mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 245	245	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase HAMAP MF_01039		PRO_0000229133
Sites
	Active site	10	1	Tele-phosphohistidine intermediate By similarity
	Active site	180	1	By similarity
	Site	61	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q5YP50 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 8E95E97A9A314C0A	FASTA	245	27,376
	10 20 30 40 50 60 MTYTLVLLRH GESEWNALNL FTGWVDVHLT DKGVAEGKRA GELLAEHGIL PDIVYTSLLR 70 80 90 100 110 120 RAISTANIAL DAADRHWIPV VRDWRLNERH YGELQGKNKA QIRDKYGEEQ FMLWRRSYDT 130 140 150 160 170 180 PPPPIEAGNE YSQEGDARYA GIDIPKTECL LDVVNRMVPY WESTISKDLL AGKTVLIAAH 190 200 210 220 230 240 GNSLRALVKH LDQISDEEIA GLNIPTGIPL RYELDENLRP VRPREYLDPE AAAAGAAAVA SQGGK

References

[1]

"The complete genomic sequence of Nocardia farcinica IFM 10152." Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M. Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IFM 10152.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AP006618 Genomic DNA. Translation: BAD60041.1.
RefSeq	YP_121405.1. NC_006361.1.
3D structure databases
ProteinModelPortal	Q5YP50.
SMR	Q5YP50. Positions 2-235.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3110754.
GenomeReviews	Gene locus NFA_51890 in contig AP006618_GR.
KEGG	nfa:nfa51890.
NMPDR	fig|247156.1.peg.4986.
PATRIC	22739967. VBINocFar94200_5202.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG658938.
OMA	EWNALNL.
ProtClustDB	PRK14120.
Enzyme and pathway databases
BioCyc	NFAR247156:NFA51890-MONOMER.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA. [Tree]
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. [Graphical view]
KO	K01834.
PANTHER	PTHR11931. Phosphogly_mut1. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. Pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA_NOCFA

Accession

Primary (citable) accession number: Q5YP50

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2006
Last sequence update:	November 23, 2004
Last modified:	January 25, 2012
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program