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Q5YNY7

- DNLI_NOCFA

UniProt

Q5YNY7 - DNLI_NOCFA

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Protein
Probable DNA ligase
Gene
lig, NFA_52520
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei210 – 2101ATP By similarity
Active sitei212 – 2121N6-AMP-lysine intermediate By similarity
Binding sitei217 – 2171ATP By similarity
Binding sitei232 – 2321ATP By similarity
Binding sitei261 – 2611ATP By similarity
Binding sitei317 – 3171ATP By similarity
Binding sitei388 – 3881ATP By similarity
Binding sitei394 – 3941ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-5323-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligase (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig
Ordered Locus Names:NFA_52520
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 523523Probable DNA ligaseUniRule annotation
PRO_0000365235Add
BLAST

Proteomic databases

PRIDEiQ5YNY7.

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa52520.

Structurei

3D structure databases

ProteinModelPortaliQ5YNY7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
KOiK01971.
OMAiIQSSPRY.
OrthoDBiEOG6Q8HXT.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YNY7-1 [UniParc]FASTAAdd to Basket

« Hide

MLFADVVRTS EAVRATRSRK TKVAALAELL RAAESAELAP VVAWLSGELR    50
QGRIGTGWRT LTGVRVPPAL DAALEVATVD AIFDELAAVS GAGSGNRRKE 100
LLTRLWSAAT EPEQEFLLRL LTGELRQGAL TALVAEAVAA AADVPVEQVR 150
RAYMLSGQLP VTAEAALRGG AAALAEFRLE VGRPIQPMLA APGASLEEAM 200
TEFGGEVSVE HKLDGARIQV HRDGDRIAVF TRTLRDITAG VPELVELVAR 250
LDCTSVVLDG ETLALTDAGR PRPFQETMSR FATADPARAA EVDLPPGTPV 300
VPPVSSTREL LLHPYFFDCL HLDGRDLLDA PLSERRAALL AVVGEHAIPA 350
LIRPEPEAAA EYFDGALAAG HEGLMVKSLS APYAAGRRGR SWQKIKPTHT 400
LDLLVLGAEW GYGRRTGYLS NLHLGARDPR TGEPVMVGKT FKGLTDALLA 450
WQTAEFPRHE RARDEHTVYL WPELVVEIAL DGVQVSPRYP GGVALRFARV 500
VRYRPDKTPD QADTIDTVRG LLP 523
Length:523
Mass (Da):56,457
Last modified:November 23, 2004 - v1
Checksum:i398B9736FF4F94BA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD60104.1.
RefSeqiWP_011211786.1. NC_006361.1.
YP_121468.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD60104; BAD60104; NFA_52520.
GeneIDi3110671.
KEGGinfa:nfa52520.
PATRICi22740091. VBINocFar94200_5264.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD60104.1 .
RefSeqi WP_011211786.1. NC_006361.1.
YP_121468.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YNY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa52520.

Proteomic databases

PRIDEi Q5YNY7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD60104 ; BAD60104 ; NFA_52520 .
GeneIDi 3110671.
KEGGi nfa:nfa52520.
PATRICi 22740091. VBINocFar94200_5264.

Phylogenomic databases

eggNOGi COG1793.
KOi K01971.
OMAi IQSSPRY.
OrthoDBi EOG6Q8HXT.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-5323-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 2 hits.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiDNLI_NOCFA
AccessioniPrimary (citable) accession number: Q5YNY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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