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Q5YNV7 (Q5YNV7_NOCFA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3 2 HAMAP MF_01815
EC=2.3.1.180 HAMAP MF_01815
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III 2 HAMAP MF_01815
Beta-ketoacyl-ACP synthase III 2 HAMAP MF_01815
Gene names
Name:fabH EMBL BAD60134.1
Synonyms:fabH2 HAMAP MF_01815
Ordered Locus Names:NFA_52820
OrganismNocardia farcinica (strain IFM 10152) [Complete proteome] [HAMAP]
Taxonomic identifier247156 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Nocardiaceae › Nocardia

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity. HAMAP MF_01815

Catalytic activity

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2. HAMAP MF_01815

Pathway

Lipid metabolism; fatty acid biosynthesis. HAMAP MF_01815 SAAS SAAS013747

Subunit structure

Homodimer By similarity. HAMAP MF_01815 SAAS SAAS013747

Subcellular location

Cytoplasm By similarity HAMAP MF_01815 SAAS SAAS013747.

Domain

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity. HAMAP MF_01815

Sequence similarities

Belongs to the FabH family. HAMAP MF_01815

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region265 – 2695ACP-binding By similarity HAMAP MF_01815

Sites

Active site1231 By similarity HAMAP MF_01815
Active site2641 By similarity HAMAP MF_01815
Active site2951 By similarity HAMAP MF_01815

Sequences

Sequence LengthMass (Da)Tools
Q5YNV7 [UniParc].

Last modified November 23, 2004. Version 1.
Checksum: F29FD4D1029F69AA

FASTA34236,105
        10         20         30         40         50         60 
MSARIAQTTG AEHTAILGLG VYRPARVVTN DEIAGPINSS DEWIRTRSGI KTRRFADETE 

        70         80         90        100        110        120 
TVQSMSVAAA RDALEAAAVA VDQVDCVIVA TSTHLLLTPA AAPRIATELG MNGAAAFDIS 

       130        140        150        160        170        180 
AGCAGFCHAL ALASDLVRAG TSKNVLVIGV EKLTDTIDMT DRSTAFLFAD GAGAVVVGPA 

       190        200        210        220        230        240 
EEPGIGPTVW GSDGTQHHAI RQNKDWIEFF TEIEEKGLDA VRPYLTMEGT AVFRWAAHSL 

       250        260        270        280        290        300 
EKVCRDAIDR AGLSTDDLRA MIPHQANGRI IEIMARVLKL PEDCALANDI EETGNTSAAS 

       310        320        330        340 
IPLAMEALLR KGESKPGDTA LLIAFGAGLS YAAQVVSLPR LK

« Hide

References

[1]"The complete genomic sequence of Nocardia farcinica IFM 10152."
Ishikawa J., Yamashita A., Mikami Y., Hoshino Y., Kurita H., Hotta K., Shiba T., Hattori M.
Proc. Natl. Acad. Sci. U.S.A. 101:14925-14930(2004) [PubMed: 15466710] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IFM 10152.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP006618 Genomic DNA. Translation: BAD60134.1.
RefSeqYP_121498.1. NC_006361.1.

3D structure databases

ProteinModelPortalQ5YNV7.
SMRQ5YNV7. Positions 3-339.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3109733.
GenomeReviewsGene locus NFA_52820 in contig AP006618_GR.
KEGGnfa:nfa52820.
NMPDRfig|247156.1.peg.5078.
PATRIC22740163. VBINocFar94200_5300.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG649927.
OMASNCFIFA.
ProtClustDBPRK09352.

Family and domain databases

HAMAPMF_01815. FabH.
[Tree]
InterProIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
Gene3DG3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
KOK11608.
PfamPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMSSF53901. Thiolase-like. 1 hit.
TIGRFAMsTIGR00747. FabH. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ5YNV7_NOCFA
AccessionPrimary (citable) accession number: Q5YNV7
Entry history
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: December 14, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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