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Q5YNA5

- TRMB_NOCFA

UniProt

Q5YNA5 - TRMB_NOCFA

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei91 – 911S-adenosyl-L-methionineUniRule annotation
    Binding sitei116 – 1161S-adenosyl-L-methionineUniRule annotation
    Binding sitei143 – 1431S-adenosyl-L-methionineUniRule annotation
    Active sitei166 – 1661By similarity
    Binding sitei166 – 1661S-adenosyl-L-methionineUniRule annotation
    Binding sitei170 – 1701SubstrateUniRule annotation
    Binding sitei202 – 2021SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-5556-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:NFA_54840
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 269269tRNA (guanine-N(7)-)-methyltransferasePRO_0000171365Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi247156.nfa54840.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5YNA5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni247 – 2504Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    KOiK03439.
    OMAiLHIATDH.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5YNA5-1 [UniParc]FASTAAdd to Basket

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    MDGVNDAANH TVESVPGRPS TASAPLEAGR RSPTGSRLYP RVTSFRSRRG    50
    ALTPNQQGAW DRMWPRIGRE VGDEPLDADA WFGRQAPLVI EIGCGTGTAT 100
    AAMAAAEPHV NLIGIEVYQP GLAQLVQRIE RDGIDNIRLL RGDAVDVLEH 150
    MIAAESLTGV RVFFPDPWPK ARHHKRRLLQ PATVALIAGR LRPGGVLHVA 200
    TDHAGYAEHI AAVGAAEPLL VGLNEATGGD DERARTLAPI GLDRPVTKFE 250
    DKAHRAGSAI TEFVWGKIE 269
    Length:269
    Mass (Da):28,933
    Last modified:November 23, 2004 - v1
    Checksum:i047088073EC83495
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD60336.1.
    RefSeqiWP_011212018.1. NC_006361.1.
    YP_121700.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD60336; BAD60336; NFA_54840.
    GeneIDi3110508.
    KEGGinfa:nfa54840.
    PATRICi22740593. VBINocFar94200_5514.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD60336.1 .
    RefSeqi WP_011212018.1. NC_006361.1.
    YP_121700.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5YNA5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa54840.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD60336 ; BAD60336 ; NFA_54840 .
    GeneIDi 3110508.
    KEGGi nfa:nfa54840.
    PATRICi 22740593. VBINocFar94200_5514.

    Phylogenomic databases

    eggNOGi COG0220.
    KOi K03439.
    OMAi LHIATDH.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci NFAR247156:GJ9T-5556-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiTRMB_NOCFA
    AccessioniPrimary (citable) accession number: Q5YNA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 15, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3