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Q5YN65

- SYL_NOCFA

UniProt

Q5YN65 - SYL_NOCFA

Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (23 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei724 – 7241ATPUniRule annotation

    GO - Molecular functioni

    1. aminoacyl-tRNA editing activity Source: InterPro
    2. ATP binding Source: UniProtKB-HAMAP
    3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciNFAR247156:GJ9T-5596-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
    Alternative name(s):
    Leucyl-tRNA synthetaseUniRule annotation
    Short name:
    LeuRSUniRule annotation
    Gene namesi
    Name:leuSUniRule annotation
    Ordered Locus Names:NFA_55240
    OrganismiNocardia farcinica (strain IFM 10152)
    Taxonomic identifieri247156 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
    ProteomesiUP000006820: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 950950Leucine--tRNA ligasePRO_0000152056Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi247156.nfa55240.

    Structurei

    3D structure databases

    ProteinModelPortaliQ5YN65.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi66 – 7712"HIGH" regionAdd
    BLAST
    Motifi721 – 7255"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0495.
    KOiK01869.
    OMAiYARYHRM.
    OrthoDBiEOG63Z74X.

    Family and domain databases

    Gene3Di1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPiMF_00049_B. Leu_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view]
    PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
    PfamiPF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view]
    PRINTSiPR00985. TRNASYNTHLEU.
    SUPFAMiSSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5YN65-1 [UniParc]FASTAAdd to Basket

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    MQDTRATESD VPEHRYNAAL AGRIERRWQQ RWLERGTFHA PNPTGPLAGP    50
    TATLPADKLF VQDMFPYPSG AGLHVGHPLG YIATDVFARY HRMRGRNVLH 100
    ALGYDAFGLP AEQYAVQTGA HPRDTTESNI ATMQRQLDRL GLGHDRRRSF 150
    ATTDPEYYRW TQWIFLQIYN AWYDLELNRA RPISELEEQF ASGARPAPDG 200
    KDWASMSQAE RAAVIDSYRL VYQTDSMVNW CPGLGTVLSN EEVTAEGRSE 250
    RGNFPVFRKR LWQWMMRITA YADRLVDDLD LLDWPENVKA MQRNWIGRSR 300
    GAQVRFDSPA GQIEVFTTRP DTLFGATYVV LAPEHDLVDA LAAAQWPADT 350
    DPRWTGGAAT PAEAVAQYRK SIAAKSDLER QENKEKTGVF LGVHAVNPVN 400
    GARVPIFIAD YVLSGYGTGA IMAVPGHDQR DWEFATAFGL PIVEVISGGD 450
    ITAAAHTGEG ELVNSDYLNG LSVEEAKATV IGRLEADGHG TGTIQYKLRD 500
    WLFARQRYWG EPFPIVYDED GAPHALPESM LPVRLPELDD FAPVTFDPDD 550
    ADSEPSPPLA KATDWVHVEL DLGDGPKKYR RDTNVMPNWA GSSWYQLRYA 600
    DPTNADAFCA KENEQYWLGP RTAEHGPDDP GGVDLYVGGV EHAVLHLLYA 650
    RFWQKVLFDL GYVSSSEPYR RLFNQGYIQA FAYTDPRGAY VPAAEVVERD 700
    GAFFWTDATG TEIEVSQEYG KIGKSLKNAI SPDEVCDQFG ADTFRFYEMS 750
    MGPLDTSRPW STKDVVGAHR FLQRVWRLVV DEETGASRVT EDAPTDETLR 800
    FLHRTIAGVD EDFAALRDNT AGAKLIELTN HLTKSYPSGT PRAAVEPLVL 850
    MLAPLAPHVA EELWERLGHS ESLAHGPFPV ADPAWLVEET VEYPIQVNGK 900
    VRSRIQVPAD ADNAAIEAAA LADEKIAALL AGATPRKLIV VPGRLVNIVA 950
    Length:950
    Mass (Da):105,624
    Last modified:November 23, 2004 - v1
    Checksum:i2F6FF32904598B35
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD60376.1.
    RefSeqiWP_011212058.1. NC_006361.1.
    YP_121740.1. NC_006361.1.

    Genome annotation databases

    EnsemblBacteriaiBAD60376; BAD60376; NFA_55240.
    GeneIDi3111210.
    KEGGinfa:nfa55240.
    PATRICi22740681. VBINocFar94200_5558.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP006618 Genomic DNA. Translation: BAD60376.1 .
    RefSeqi WP_011212058.1. NC_006361.1.
    YP_121740.1. NC_006361.1.

    3D structure databases

    ProteinModelPortali Q5YN65.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 247156.nfa55240.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAD60376 ; BAD60376 ; NFA_55240 .
    GeneIDi 3111210.
    KEGGi nfa:nfa55240.
    PATRICi 22740681. VBINocFar94200_5558.

    Phylogenomic databases

    eggNOGi COG0495.
    KOi K01869.
    OMAi YARYHRM.
    OrthoDBi EOG63Z74X.

    Enzyme and pathway databases

    BioCyci NFAR247156:GJ9T-5596-MONOMER.

    Family and domain databases

    Gene3Di 1.10.730.10. 1 hit.
    3.40.50.620. 4 hits.
    3.90.740.10. 1 hit.
    HAMAPi MF_00049_B. Leu_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002302. Leu-tRNA-ligase.
    IPR025709. Leu_tRNA-synth_edit.
    IPR015413. Methionyl/Leucyl_tRNA_Synth.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR009080. tRNAsynth_1a_anticodon-bd.
    IPR013155. V/L/I-tRNA-synth_anticodon-bd.
    IPR009008. Val/Leu/Ile-tRNA-synth_edit.
    [Graphical view ]
    PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
    Pfami PF08264. Anticodon_1. 1 hit.
    PF13603. tRNA-synt_1_2. 1 hit.
    PF09334. tRNA-synt_1g. 1 hit.
    [Graphical view ]
    PRINTSi PR00985. TRNASYNTHLEU.
    SUPFAMi SSF47323. SSF47323. 1 hit.
    SSF50677. SSF50677. 1 hit.
    TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IFM 10152.

    Entry informationi

    Entry nameiSYL_NOCFA
    AccessioniPrimary (citable) accession number: Q5YN65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 1, 2005
    Last sequence update: November 23, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3