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Q5YN65

- SYL_NOCFA

UniProt

Q5YN65 - SYL_NOCFA

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei724 – 7241ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-5596-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:NFA_55240
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Leucine--tRNA ligasePRO_0000152056Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa55240.

Structurei

3D structure databases

ProteinModelPortaliQ5YN65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 7712"HIGH" regionAdd
BLAST
Motifi721 – 7255"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YN65-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQDTRATESD VPEHRYNAAL AGRIERRWQQ RWLERGTFHA PNPTGPLAGP
60 70 80 90 100
TATLPADKLF VQDMFPYPSG AGLHVGHPLG YIATDVFARY HRMRGRNVLH
110 120 130 140 150
ALGYDAFGLP AEQYAVQTGA HPRDTTESNI ATMQRQLDRL GLGHDRRRSF
160 170 180 190 200
ATTDPEYYRW TQWIFLQIYN AWYDLELNRA RPISELEEQF ASGARPAPDG
210 220 230 240 250
KDWASMSQAE RAAVIDSYRL VYQTDSMVNW CPGLGTVLSN EEVTAEGRSE
260 270 280 290 300
RGNFPVFRKR LWQWMMRITA YADRLVDDLD LLDWPENVKA MQRNWIGRSR
310 320 330 340 350
GAQVRFDSPA GQIEVFTTRP DTLFGATYVV LAPEHDLVDA LAAAQWPADT
360 370 380 390 400
DPRWTGGAAT PAEAVAQYRK SIAAKSDLER QENKEKTGVF LGVHAVNPVN
410 420 430 440 450
GARVPIFIAD YVLSGYGTGA IMAVPGHDQR DWEFATAFGL PIVEVISGGD
460 470 480 490 500
ITAAAHTGEG ELVNSDYLNG LSVEEAKATV IGRLEADGHG TGTIQYKLRD
510 520 530 540 550
WLFARQRYWG EPFPIVYDED GAPHALPESM LPVRLPELDD FAPVTFDPDD
560 570 580 590 600
ADSEPSPPLA KATDWVHVEL DLGDGPKKYR RDTNVMPNWA GSSWYQLRYA
610 620 630 640 650
DPTNADAFCA KENEQYWLGP RTAEHGPDDP GGVDLYVGGV EHAVLHLLYA
660 670 680 690 700
RFWQKVLFDL GYVSSSEPYR RLFNQGYIQA FAYTDPRGAY VPAAEVVERD
710 720 730 740 750
GAFFWTDATG TEIEVSQEYG KIGKSLKNAI SPDEVCDQFG ADTFRFYEMS
760 770 780 790 800
MGPLDTSRPW STKDVVGAHR FLQRVWRLVV DEETGASRVT EDAPTDETLR
810 820 830 840 850
FLHRTIAGVD EDFAALRDNT AGAKLIELTN HLTKSYPSGT PRAAVEPLVL
860 870 880 890 900
MLAPLAPHVA EELWERLGHS ESLAHGPFPV ADPAWLVEET VEYPIQVNGK
910 920 930 940 950
VRSRIQVPAD ADNAAIEAAA LADEKIAALL AGATPRKLIV VPGRLVNIVA
Length:950
Mass (Da):105,624
Last modified:November 23, 2004 - v1
Checksum:i2F6FF32904598B35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD60376.1.
RefSeqiYP_121740.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD60376; BAD60376; NFA_55240.
GeneIDi3111210.
KEGGinfa:nfa55240.
PATRICi22740681. VBINocFar94200_5558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD60376.1 .
RefSeqi YP_121740.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YN65.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa55240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD60376 ; BAD60376 ; NFA_55240 .
GeneIDi 3111210.
KEGGi nfa:nfa55240.
PATRICi 22740681. VBINocFar94200_5558.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-5596-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiSYL_NOCFA
AccessioniPrimary (citable) accession number: Q5YN65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3