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Q5YN65

- SYL_NOCFA

UniProt

Q5YN65 - SYL_NOCFA

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Protein
Leucine--tRNA ligase
Gene
leuS, NFA_55240
Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei724 – 7241ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. aminoacyl-tRNA editing activity Source: InterPro
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNFAR247156:GJ9T-5596-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:NFA_55240
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeNocardiaceaeNocardia
ProteomesiUP000006820: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 950950Leucine--tRNA ligaseUniRule annotation
PRO_0000152056Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa55240.

Structurei

3D structure databases

ProteinModelPortaliQ5YN65.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi66 – 7712"HIGH" regionUniRule annotation
Add
BLAST
Motifi721 – 7255"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
KOiK01869.
OMAiYARYHRM.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5YN65-1 [UniParc]FASTAAdd to Basket

« Hide

MQDTRATESD VPEHRYNAAL AGRIERRWQQ RWLERGTFHA PNPTGPLAGP    50
TATLPADKLF VQDMFPYPSG AGLHVGHPLG YIATDVFARY HRMRGRNVLH 100
ALGYDAFGLP AEQYAVQTGA HPRDTTESNI ATMQRQLDRL GLGHDRRRSF 150
ATTDPEYYRW TQWIFLQIYN AWYDLELNRA RPISELEEQF ASGARPAPDG 200
KDWASMSQAE RAAVIDSYRL VYQTDSMVNW CPGLGTVLSN EEVTAEGRSE 250
RGNFPVFRKR LWQWMMRITA YADRLVDDLD LLDWPENVKA MQRNWIGRSR 300
GAQVRFDSPA GQIEVFTTRP DTLFGATYVV LAPEHDLVDA LAAAQWPADT 350
DPRWTGGAAT PAEAVAQYRK SIAAKSDLER QENKEKTGVF LGVHAVNPVN 400
GARVPIFIAD YVLSGYGTGA IMAVPGHDQR DWEFATAFGL PIVEVISGGD 450
ITAAAHTGEG ELVNSDYLNG LSVEEAKATV IGRLEADGHG TGTIQYKLRD 500
WLFARQRYWG EPFPIVYDED GAPHALPESM LPVRLPELDD FAPVTFDPDD 550
ADSEPSPPLA KATDWVHVEL DLGDGPKKYR RDTNVMPNWA GSSWYQLRYA 600
DPTNADAFCA KENEQYWLGP RTAEHGPDDP GGVDLYVGGV EHAVLHLLYA 650
RFWQKVLFDL GYVSSSEPYR RLFNQGYIQA FAYTDPRGAY VPAAEVVERD 700
GAFFWTDATG TEIEVSQEYG KIGKSLKNAI SPDEVCDQFG ADTFRFYEMS 750
MGPLDTSRPW STKDVVGAHR FLQRVWRLVV DEETGASRVT EDAPTDETLR 800
FLHRTIAGVD EDFAALRDNT AGAKLIELTN HLTKSYPSGT PRAAVEPLVL 850
MLAPLAPHVA EELWERLGHS ESLAHGPFPV ADPAWLVEET VEYPIQVNGK 900
VRSRIQVPAD ADNAAIEAAA LADEKIAALL AGATPRKLIV VPGRLVNIVA 950
Length:950
Mass (Da):105,624
Last modified:November 23, 2004 - v1
Checksum:i2F6FF32904598B35
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD60376.1.
RefSeqiWP_011212058.1. NC_006361.1.
YP_121740.1. NC_006361.1.

Genome annotation databases

EnsemblBacteriaiBAD60376; BAD60376; NFA_55240.
GeneIDi3111210.
KEGGinfa:nfa55240.
PATRICi22740681. VBINocFar94200_5558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP006618 Genomic DNA. Translation: BAD60376.1 .
RefSeqi WP_011212058.1. NC_006361.1.
YP_121740.1. NC_006361.1.

3D structure databases

ProteinModelPortali Q5YN65.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 247156.nfa55240.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAD60376 ; BAD60376 ; NFA_55240 .
GeneIDi 3111210.
KEGGi nfa:nfa55240.
PATRICi 22740681. VBINocFar94200_5558.

Phylogenomic databases

eggNOGi COG0495.
KOi K01869.
OMAi YARYHRM.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci NFAR247156:GJ9T-5596-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 4 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IFM 10152.

Entry informationi

Entry nameiSYL_NOCFA
AccessioniPrimary (citable) accession number: Q5YN65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: September 3, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi