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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Nocardia farcinica (strain IFM 10152)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei724ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciNFAR247156:G1G24-5519-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:NFA_55240
OrganismiNocardia farcinica (strain IFM 10152)
Taxonomic identifieri247156 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesNocardiaceaeNocardia
Proteomesi
  • UP000006820 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001520561 – 950Leucine--tRNA ligaseAdd BLAST950

Proteomic databases

PRIDEiQ5YN65

Interactioni

Protein-protein interaction databases

STRINGi247156.nfa55240

Structurei

3D structure databases

ProteinModelPortaliQ5YN65
SMRiQ5YN65
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi66 – 77"HIGH" regionAdd BLAST12
Motifi721 – 725"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 3 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 1 hit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q5YN65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDTRATESD VPEHRYNAAL AGRIERRWQQ RWLERGTFHA PNPTGPLAGP
60 70 80 90 100
TATLPADKLF VQDMFPYPSG AGLHVGHPLG YIATDVFARY HRMRGRNVLH
110 120 130 140 150
ALGYDAFGLP AEQYAVQTGA HPRDTTESNI ATMQRQLDRL GLGHDRRRSF
160 170 180 190 200
ATTDPEYYRW TQWIFLQIYN AWYDLELNRA RPISELEEQF ASGARPAPDG
210 220 230 240 250
KDWASMSQAE RAAVIDSYRL VYQTDSMVNW CPGLGTVLSN EEVTAEGRSE
260 270 280 290 300
RGNFPVFRKR LWQWMMRITA YADRLVDDLD LLDWPENVKA MQRNWIGRSR
310 320 330 340 350
GAQVRFDSPA GQIEVFTTRP DTLFGATYVV LAPEHDLVDA LAAAQWPADT
360 370 380 390 400
DPRWTGGAAT PAEAVAQYRK SIAAKSDLER QENKEKTGVF LGVHAVNPVN
410 420 430 440 450
GARVPIFIAD YVLSGYGTGA IMAVPGHDQR DWEFATAFGL PIVEVISGGD
460 470 480 490 500
ITAAAHTGEG ELVNSDYLNG LSVEEAKATV IGRLEADGHG TGTIQYKLRD
510 520 530 540 550
WLFARQRYWG EPFPIVYDED GAPHALPESM LPVRLPELDD FAPVTFDPDD
560 570 580 590 600
ADSEPSPPLA KATDWVHVEL DLGDGPKKYR RDTNVMPNWA GSSWYQLRYA
610 620 630 640 650
DPTNADAFCA KENEQYWLGP RTAEHGPDDP GGVDLYVGGV EHAVLHLLYA
660 670 680 690 700
RFWQKVLFDL GYVSSSEPYR RLFNQGYIQA FAYTDPRGAY VPAAEVVERD
710 720 730 740 750
GAFFWTDATG TEIEVSQEYG KIGKSLKNAI SPDEVCDQFG ADTFRFYEMS
760 770 780 790 800
MGPLDTSRPW STKDVVGAHR FLQRVWRLVV DEETGASRVT EDAPTDETLR
810 820 830 840 850
FLHRTIAGVD EDFAALRDNT AGAKLIELTN HLTKSYPSGT PRAAVEPLVL
860 870 880 890 900
MLAPLAPHVA EELWERLGHS ESLAHGPFPV ADPAWLVEET VEYPIQVNGK
910 920 930 940 950
VRSRIQVPAD ADNAAIEAAA LADEKIAALL AGATPRKLIV VPGRLVNIVA
Length:950
Mass (Da):105,624
Last modified:November 23, 2004 - v1
Checksum:i2F6FF32904598B35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP006618 Genomic DNA Translation: BAD60376.1
RefSeqiWP_011212058.1, NC_006361.1

Genome annotation databases

EnsemblBacteriaiBAD60376; BAD60376; NFA_55240
KEGGinfa:NFA_55240

Similar proteinsi

Entry informationi

Entry nameiSYL_NOCFA
AccessioniPrimary (citable) accession number: Q5YN65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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