Q5YLH5 (HXA6_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-A6

Gene names

Name:

HOXA6

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Homeobox protein Hox-A6		PRO_0000200069
Regions
	DNA binding	153 – 212	60	Homeobox
	Motif	134 – 139	6	Antp-type hexapeptide

Sequences

	Sequence		Length	Mass (Da)
	Q5YLH5 [UniParc]. Last modified November 23, 2004. Version 1. Checksum: 437DB6474C74C7FD	FASTA	231	26,510
	10 20 30 40 50 60 MSSYFVNPTF PGSLPAGQDS FLGQIPLYPA GYDALRHFPT SYGASSLQDK TYTSPCFYQQ 70 80 90 100 110 120 SNTVIACNRA SYEYGASCFY SDKEISSASP SGSGKQRGQG DYLHFSPEQQ YKSNGVQSKI 130 140 150 160 170 180 VNDEGTDRKY TSPVYPWMQR MNSCAGTVYG AHGRRGRQTY TRYQTLELEK EFHFNRYLTR 190 200 210 220 230 RRRIEIANAL CLTERQIKIW FQNRRMKWKK ENKFINSTQP GSDETEEKSG E

References

[1]	"Expression and regulation of Hoxa5-7 during chick wing specification and outgrowth." Oberg K.C., Pira C.U., Caltharp S.A., Naruse T., Eichele G., Brunick L., Burke A.C. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY307380 mRNA. Translation: AAQ81318.1.
IPI	IPI00598309.
RefSeq	NP_001026158.1. NM_001030987.1.
UniGene	Gga.22376.
3D structure databases
ProteinModelPortal	Q5YLH5.
SMR	Q5YLH5. Positions 128-213.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	420630.
KEGG	gga:420630.
Organism-specific databases
CTD	3203.
Phylogenomic databases
HOVERGEN	HBG016849.
Family and domain databases
InterPro	IPR001356. Homeobox. IPR017995. Homeobox_antennapedia. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_eu. IPR009057. Homeodomain-like. IPR012287. Homeodomain-rel. [Graphical view]
Gene3D	G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.
KO	K09306.
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00025. ANTENNAPEDIA. PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXA6_CHICK

Accession

Primary (citable) accession number: Q5YLH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	November 23, 2004
Last modified:	December 14, 2011
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program