Q5YLC1 (Q5YLC1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names	Submitted name: TGIF-interacting ubiquitin ligase 1 EMBL AAQ22764.1
Organism	Homo sapiens (Human) EMBL AAQ22764.1
Taxonomic identifier	9606 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	922 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412 SAAS SAAS001202 Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. SAAS SAAS000569

Ontologies

Keywords
Biological process	Ubl conjugation pathway SAAS SAAS000569
Molecular function	Ligase EMBL AAQ22764.1
Gene Ontology (GO)
Biological process	protein modification process Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	acid-amino acid ligase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5YLC1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 35B6E1C03A3147DA	FASTA	922	105,202
	10 20 30 40 50 60 MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI TKTAKSSSSS 70 80 90 100 110 120 NPKWDEQLTV NVTPQTTLEF QVWSHRTLKA DALLGKATID LKQALLIHNR KLERVKEQLK 130 140 150 160 170 180 LSLENKNGIA QTGELTVVLD GLVIEQENIT NCSSSPTIEI QENGDALHEN GEPSARTTAR 190 200 210 220 230 240 LAVEGTNGID NHVPTSTLVQ NSCCSYVVNG DNTPSSPSQV AARPKNTPAP KPLASEPADD 250 260 270 280 290 300 TVNGESSSFA PTDNASVTGT PVVSEENALS PNCTSTTVED PPVQEILTSS ENNECIPSTS 310 320 330 340 350 360 AELESEARSI LEPDTSNSRS SSAFEAAKSR QPDGCMDPVR QQSGNANTET LPSGWEQRKD 370 380 390 400 410 420 PHGRTYYVDH NTRTTTWERP QPLPPGWERR VDDRRRVYYV DHNTRTTTWQ RPTMESVRNF 430 440 450 460 470 480 EQWQSQRNQL QGAMQQFNQR YLYSASMLAA ENDPYGPLPP GWEKRVDSTD RVYFVNHNTK 490 500 510 520 530 540 TTQWEDPRTQ GLQNEEPLPE GWEIRYTREG VRYFVDHNTR TTTFKDPRNG KSSVTKGGPQ 550 560 570 580 590 600 IAYERGFRWK LAHFRYLCQS NALPSHVKIN VSRQTLFEDS FQQIMALKPY DLRRRLYVIF 610 620 630 640 650 660 RGEEGLDYGG LAREWFFLLS HEVLNPMYCL FEYAGKNNYC LQINPASTIN PDHLSYFCFI 670 680 690 700 710 720 GRFIAMALFH GKFIDTGFSL PFYKRMLSKK LTIKDLESID TEFYNSLIWI RDNNIEECGL 730 740 750 760 770 780 EMYFSVDMEI LGKVTSHDLK LGGSNILVTE ENKDEYIGLM TEWRFSRGVQ EQTKAFLDGF 790 800 810 820 830 840 NEVVPLQWLQ YFDEKELEVM LCGMQEVDLA DWQRNTVYRH YTRNSKQIIW FWQFVKETDN 850 860 870 880 890 900 EVRMRLLQFV TGTCRLPLGG FAELMGSNGP QKFCIEKVGK DTWLPRSHTC FNRLDLPPYK 910 920 SYEQLKEKLL FAIEETEGFG QE

References

[1]	"The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation." Seo S.R., Lallemand F., Ferrand N., Pessah M., L'Hoste S., Camonis J., Atfi A. EMBO J. 23:3780-3792(2004) [PubMed: 15359284] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY345857 mRNA. Translation: AAQ22764.1.
IPI	IPI00013009.
RefSeq	NP_008944.1. NM_007013.3.
UniGene	Hs.655189.
3D structure databases
ProteinModelPortal	Q5YLC1.
SMR	Q5YLC1. Positions 13-145, 346-917.
ModBase	Search...
Protein-protein interaction databases
STRING	Q5YLC1.
Proteomic databases
PRIDE	Q5YLC1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	11059.
KEGG	hsa:11059.
Organism-specific databases
CTD	11059.
PharmGKB	PA134960138.
Phylogenomic databases
GeneTree	ENSGT00570000078756.
HOVERGEN	HBG004134.
OMA	EFRVWSH.
PhylomeDB	Q5YLC1.
Gene expression databases
ArrayExpress	Q5YLC1.
Bgee	Q5YLC1.
Family and domain databases
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR024928. E3_ub_ligase_SMURF1. IPR000569. HECT. IPR001202. WW_Rsp5_WWP. [Graphical view]
Gene3D	G3DSA:2.20.70.10. G3DSA:2.20.70.10. 4 hits.
KO	K05633.
Pfam	PF00168. C2. 1 hit. PF00632. HECT. 1 hit. PF00397. WW. 4 hits. [Graphical view]
PIRSF	PIRSF001569. E3_ub_ligase_SMURF1. 1 hit.
SMART	SM00239. C2. 1 hit. SM00119. HECTc. 1 hit. SM00456. WW. 4 hits. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 1 hit. SSF56204. HECT. 1 hit. SSF51045. WW_Rsp5_WWP. 4 hits.
PROSITE	PS50004. C2. 1 hit. PS50237. HECT. 1 hit. PS01159. WW_DOMAIN_1. 4 hits. PS50020. WW_DOMAIN_2. 4 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	42019.

Entry information

Entry name

Q5YLC1_HUMAN

Accession

Primary (citable) accession number: Q5YLC1

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.