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Unreviewed, UniProtKB/TrEMBL Q5YLC1 (Q5YLC1_HUMAN)

Last modified November 4, 2008. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    TGIF-interacting ubiquitin ligase 1 EMBL AAQ22764.1
OrganismHomo sapiens (Human) EMBL AAQ22764.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length922 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Sequence similarities

Contains 1 C2 domain. RuleBase RU003412V0

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Spearmint SPM000569

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Ontologies

Keywords

   Biological processUbl conjugation pathway Spearmint SPM000569
   Molecular functionLigase

Gene Ontology (GO)

   Uncategorizedubiquitin cycle

Inferred from electronic annotation. Source: InterPro

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

ubiquitin-protein ligase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q5YLC1-1 [UniParc].

Last modified May 10, 2005. Version 1.
Checksum: 35B6E1C03A3147DA

FASTA922105,202
        10         20         30         40         50         60 
MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI TKTAKSSSSS 

        70         80         90        100        110        120 
NPKWDEQLTV NVTPQTTLEF QVWSHRTLKA DALLGKATID LKQALLIHNR KLERVKEQLK 

       130        140        150        160        170        180 
LSLENKNGIA QTGELTVVLD GLVIEQENIT NCSSSPTIEI QENGDALHEN GEPSARTTAR 

       190        200        210        220        230        240 
LAVEGTNGID NHVPTSTLVQ NSCCSYVVNG DNTPSSPSQV AARPKNTPAP KPLASEPADD 

       250        260        270        280        290        300 
TVNGESSSFA PTDNASVTGT PVVSEENALS PNCTSTTVED PPVQEILTSS ENNECIPSTS 

       310        320        330        340        350        360 
AELESEARSI LEPDTSNSRS SSAFEAAKSR QPDGCMDPVR QQSGNANTET LPSGWEQRKD 

       370        380        390        400        410        420 
PHGRTYYVDH NTRTTTWERP QPLPPGWERR VDDRRRVYYV DHNTRTTTWQ RPTMESVRNF 

       430        440        450        460        470        480 
EQWQSQRNQL QGAMQQFNQR YLYSASMLAA ENDPYGPLPP GWEKRVDSTD RVYFVNHNTK 

       490        500        510        520        530        540 
TTQWEDPRTQ GLQNEEPLPE GWEIRYTREG VRYFVDHNTR TTTFKDPRNG KSSVTKGGPQ 

       550        560        570        580        590        600 
IAYERGFRWK LAHFRYLCQS NALPSHVKIN VSRQTLFEDS FQQIMALKPY DLRRRLYVIF 

       610        620        630        640        650        660 
RGEEGLDYGG LAREWFFLLS HEVLNPMYCL FEYAGKNNYC LQINPASTIN PDHLSYFCFI 

       670        680        690        700        710        720 
GRFIAMALFH GKFIDTGFSL PFYKRMLSKK LTIKDLESID TEFYNSLIWI RDNNIEECGL 

       730        740        750        760        770        780 
EMYFSVDMEI LGKVTSHDLK LGGSNILVTE ENKDEYIGLM TEWRFSRGVQ EQTKAFLDGF 

       790        800        810        820        830        840 
NEVVPLQWLQ YFDEKELEVM LCGMQEVDLA DWQRNTVYRH YTRNSKQIIW FWQFVKETDN 

       850        860        870        880        890        900 
EVRMRLLQFV TGTCRLPLGG FAELMGSNGP QKFCIEKVGK DTWLPRSHTC FNRLDLPPYK 

       910        920 
SYEQLKEKLL FAIEETEGFG QE

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References

[1]"The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation."
Seo S.R., Lallemand F., Ferrand N., Pessah M., L'Hoste S., Camonis J., Atfi A.
EMBO J. 23:3780-3792(2004) [PubMed: 15359284] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AY345857 mRNA. Translation: AAQ22764.1.
RefSeqNP_008944.1.
UniGeneHs.655189

3D structure databases

SMRQ5YLC1. Positions 453-528.
ModBaseSearch...

Genome annotation databases

EnsemblENSG00000123124. Homo sapiens. [Contig view]
GeneID11059.
KEGGhsa:11059.

Organism-specific databases

HGNCHGNC:17004. WWP1.
GeneCardsSearch...

Phylogenomic databases

HOVERGENQ5YLC1.

Gene expression databases

ArrayExpressQ5YLC1.

Family and domain databases

InterProIPR000008. C2_Ca-dep.
IPR000569. HECT.
IPR002349. WW.
IPR001202. WW_Rsp5_WWP.
[Graphical view]
PfamPF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 4 hits.
[Graphical view]
PRINTSPR00403. WWDOMAIN.
SMARTSM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 4 hits.
[Graphical view]
PROSITEPS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 4 hits.
PS50020. WW_DOMAIN_2. 2 hits.
[Graphical view]

Other Resources

NextBio42019.

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Entry information

Entry nameQ5YLC1_HUMAN
AccessionPrimary (citable) accession number: Q5YLC1
Entry history
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 4, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information