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Protein

E3 ubiquitin-protein ligase

Gene

Itch

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.UniRule annotationSAAS annotation

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei822Glycyl thioester intermediateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseImported, TransferaseUniRule annotationSAAS annotation
Biological processUbl conjugation pathwayUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligaseUniRule annotation (EC:2.3.2.26UniRule annotation)
Gene namesi
Name:ItchImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi1359556. Itch.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ5YB86.

PTM databases

iPTMnetiQ5YB86.
PhosphoSitePlusiQ5YB86.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ5YB86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 89C2InterPro annotationAdd BLAST89
Domaini277 – 310WWInterPro annotationAdd BLAST34
Domaini309 – 342WWInterPro annotationAdd BLAST34
Domaini389 – 422WWInterPro annotationAdd BLAST34
Domaini429 – 462WWInterPro annotationAdd BLAST34
Domaini520 – 854HECTInterPro annotationAdd BLAST335

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
HOGENOMiHOG000208453.
HOVERGENiHBG004134.
KOiK05632.
PhylomeDBiQ5YB86.

Family and domain databases

CDDicd00078. HECTc. 1 hit.
cd00201. WW. 4 hits.
Gene3Di2.60.40.150. 1 hit.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR024928. E3_ub_ligase_SMURF1.
IPR000569. HECT_dom.
IPR035983. Hect_E3_ubiquitin_ligase.
IPR001202. WW_dom.
IPR036020. WW_dom_sf.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF00632. HECT. 1 hit.
PF00397. WW. 3 hits.
PIRSFiPIRSF001569. E3_ub_ligase_SMURF1. 3 hits.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00119. HECTc. 1 hit.
SM00456. WW. 4 hits.
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51045. SSF51045. 4 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 3 hits.
PS50020. WW_DOMAIN_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Q5YB86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT
60 70 80 90 100
NSPKWKQPLT VIVTPMSKLC FRVWSHQTLK SDVLLGTAGL DIYETLKSNN
110 120 130 140 150
MKLEEVVMTL QLVGDKEPTE TMGDLSVCLD GLQVEAEVVT NGETSCSEGA
160 170 180 190 200
TQNDAGCRPK DETRVSTNGS EDPEVAASGE NKRANGNNSP SLSNGGFKPS
210 220 230 240 250
RPPRPSRPPP PTPRRPASVN GSPSTNSDSD GSSTGSLPPT NTNVNSSASE
260 270 280 290 300
GAASGLIIPR TISGGSGPRP LNTVSQAPLP PGWEQRVDQH GRAYYVDHVE
310 320 330 340 350
KRTTRDRPEP LPPGWERRVD NMGRIYYVDH FTRTTTWQRP TLESVRNYEQ
360 370 380 390 400
WQLQRSQLQG AMQQFNQRFI FGNQDLFATS QNKEFDPLGP LPPGWEKRTD
410 420 430 440 450
SNGRVYFVNH NTRITQWEDP RSQGQLNEKP LPEGWEMRFT VDGIPYFVDH
460 470 480 490 500
NRRATTYIDP RTGKSALDNG PQIAYVRDFK AKVQYFRFWC QQLAMPQHIK
510 520 530 540 550
ITVTRKTLFE DSFQQIMSFS PQDLRRRLWV IFPGEEGLDY GGVAREWFFL
560 570 580 590 600
LSHEVLNPMY CLFEYAGKDN YCLQINPASY INPDHLKYFR FIGRFIAMAL
610 620 630 640 650
FHGKFIDTGF SLPFYKRILN KPVGLKDLES IDPEFYNSLI WVKENNIEEC
660 670 680 690 700
GLEMYFSVDK EILGEIKSHD LKPNGGNILV TEENKEEYIR MVAEWRLSRG
710 720 730 740 750
VEEQTQAFFE GFNEILPQQY LQYFDAKELE VLLCGMQEID LNDWQRHAIY
760 770 780 790 800
RHYTRTSKQI VWFWQFVKEI DNEKRMRLLQ FVTGTCRLPV GGFADLMGSN
810 820 830 840 850
GPQKFCIEKV GKENWLPRSH TCFNRLDLPP YKSYEQLKEK LLFAIEETEG

FGQE
Length:854
Mass (Da):97,746
Last modified:November 23, 2004 - v1
Checksum:iD05FF6FAE119D8BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY600518 mRNA. Translation: AAT46068.1.
RefSeqiNP_001005887.1. NM_001005887.1.
UniGeneiRn.20718.

Genome annotation databases

GeneIDi311567.
KEGGirno:311567.
UCSCiRGD:1359556. rat.

Similar proteinsi

Entry informationi

Entry nameiQ5YB86_RAT
AccessioniPrimary (citable) accession number: Q5YB86
Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 22, 2017
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)