ID Q5Y7D6_HUMAN Unreviewed; 261 AA. AC Q5Y7D6; DT 10-MAY-2005, integrated into UniProtKB/TrEMBL. DT 10-MAY-2005, sequence version 1. DT 24-JAN-2024, entry version 174. DE SubName: Full=HLA class II histocompatibility antigen DQ beta chain {ECO:0000313|EMBL:BBD34192.1}; DE SubName: Full=HLA class II histocompatibility antigen, DQ beta 1 chain {ECO:0000313|Ensembl:ENSP00000382034}; DE SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AAU88009.1}; DE SubName: Full=cDNA, FLJ79232, highly similar to HLA class II histocompatibility antigen, DQB1*0602 beta chain {ECO:0000313|EMBL:BAH14704.1}; GN Name=HLA-DQB1 {ECO:0000313|EMBL:AAU88009.1, GN ECO:0000313|Ensembl:ENSP00000382034}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:AAU88009.1}; RN [1] {ECO:0000313|Ensembl:ENSP00000382034, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=14574404; DOI=10.1038/nature02055; RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., RA Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I., RA Rogers J., Beck S.; RT "The DNA sequence and analysis of human chromosome 6."; RL Nature 425:805-811(2003). RN [2] {ECO:0000313|EMBL:AAU88009.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=16140993; DOI=10.1101/gr.3554305; RA Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S., RA Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V.; RT "Ancient haplotypes of the HLA Class II region."; RL Genome Res. 15:1250-1257(2005). RN [3] {ECO:0000313|EMBL:BAH14704.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Spleen {ECO:0000313|EMBL:BAH14704.1}; RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A., RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y., RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T., RA Sugano S., Nomura N., Isogai T.; RT "NEDO human cDNA sequencing project."; RL Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0007829|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [5] {ECO:0000313|Ensembl:ENSP00000382034} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [6] {ECO:0000313|EMBL:BAN59788.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=23714642; DOI=10.1186/1471-2164-14-355; RA Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.; RT "Phase-defined complete sequencing of the HLA genes by next-generation RT sequencing."; RL BMC Genomics 14:355-355(2013). RN [7] {ECO:0000313|EMBL:AGW82949.2} RP NUCLEOTIDE SEQUENCE. RA Li J.; RT "44 novel HLA-DQB1 alleles found by BGI in 2011 year."; RL Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases. RN [8] {ECO:0000313|EMBL:CUX91065.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=28547825; DOI=10.1111/tan.13057; RA Albrecht V., Zweiniger C., Surendranath V., Lang K., Schofl G., Dahl A., RA Winkler S., Lange V., Bohme I., Schmidt A.H.; RT "Dual redundant sequencing strategy: Full-length gene characterisation of RT 1056 novel and confirmatory HLA alleles."; RL HLA 90:79-87(2017). RN [9] {ECO:0000313|EMBL:AVN68388.1} RP NUCLEOTIDE SEQUENCE. RA Balz V., Krause S., Enczmann J., Fischer J.; RT "New variants of HLA-DQB1."; RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases. RN [10] {ECO:0000313|EMBL:BBD34192.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=30337930; DOI=.3389/fimmu.2018.02294; RA Suzuki S., Ranade S., Osaki K., Ito S., Shigenari A., Ohnuki Y., Oka A., RA Masuya A., Harting J., Baybayan P., Kitazume M., Sunaga J., Morishima S., RA Morishima Y., Inoko H., Kulski J.K., Shiina T.; RT "Reference Grade Characterization of Polymorphisms in Full-Length HLA Class RT I and II Genes With Short-Read Sequencing on the ION PGM System and Long- RT Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio RT Platform."; RL Front. Immunol. 9:2294-2294(2018). RN [11] {ECO:0000313|EMBL:AST16107.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29327506; DOI=.1111/tan.13210; RA Hurley C.K., Hou L., Lazaro A., Gerfen J., Enriquez E., Galarza P., RA Rodriguez Cardozo M.B., Halagan M., Maiers M., Behm D., Ng J.; RT "Next generation sequencing characterizes the extent of HLA diversity in an RT Argentinian registry population."; RL HLA 91:175-186(2018). RN [12] {ECO:0000313|EMBL:QHR76763.1} RP NUCLEOTIDE SEQUENCE. RA Alizadeh M.; RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases. RN [13] {ECO:0000313|EMBL:BBN51266.1} RP NUCLEOTIDE SEQUENCE. RA Yamamoto F., Suzuki S., Mizutani A., Shigenari A., Ito S., Kametani Y., RA Kato S., Fernandez-Vina M., Murata M., Morishima S., Morishima Y., RA Tanaka M., Kulski J.K., Bahram S., Shiina T.; RT "Capturing Differential Allele-Level Expression and Genotypes of All RT Classical HLA Loci and Haplotypes by a New Capture RNA-Seq Method."; RL Front. Immunol. 11:0-941(2020). RN [14] {ECO:0000313|EMBL:QJQ23414.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=31981322; RA Vianna R., Turner T., Georgiou X., Porto L.C.; RT "Characterization of two novel HLA-DQB1*06:02:01 variants, identified in RT Brazilian individuals."; RL HLA 0:0-0(2020). RN [15] {ECO:0000313|EMBL:CAB0472741.1} RP NUCLEOTIDE SEQUENCE. RA Albrecht V., Schmidt H. A., Klussmeier A., Lange V., Putke K.; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [16] {ECO:0000313|EMBL:QIB02187.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:QIB02187.1}; RA Ananeva A.V., Leksina Y.A., Shagimardanova E.I.; RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases. RN [17] {ECO:0000313|EMBL:QSD59104.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=DQ06NEW_Amelie_017418984 {ECO:0000313|EMBL:QSD59104.1}; RA Senoussi O., Dard C.; RL Submitted (FEB-2021) to the EMBL/GenBank/DDBJ databases. RN [18] {ECO:0000313|EMBL:QWE90336.1} RP NUCLEOTIDE SEQUENCE. RA Vianna R., Porto L.C.; RL Submitted (MAY-2021) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Endosome membrane CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane CC {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein CC {ECO:0000256|ARBA:ARBA00004352}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL662789; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AY663395; AAU87980.1; -; Genomic_DNA. DR EMBL; AY663406; AAU88009.1; -; Genomic_DNA. DR EMBL; AY663411; AAU88024.1; -; Genomic_DNA. DR EMBL; KF270555; AGW82949.2; -; Genomic_DNA. DR EMBL; MF417566; AST16107.1; -; Genomic_DNA. DR EMBL; KY856767; AVN68388.1; -; Genomic_DNA. DR EMBL; KY856768; AVN68389.1; -; Genomic_DNA. DR EMBL; AK316333; BAH14704.1; -; mRNA. DR EMBL; AB774942; BAN59788.1; -; Genomic_DNA. DR EMBL; AB774978; BAN59824.1; -; Genomic_DNA. DR EMBL; LC257874; BBD34192.1; -; Genomic_DNA. DR EMBL; LC499658; BBN51266.1; -; mRNA. DR EMBL; LR777707; CAB0472741.1; -; Genomic_DNA. DR EMBL; LR777790; CAB0472824.1; -; Genomic_DNA. DR EMBL; LR777795; CAB0472829.1; -; Genomic_DNA. DR EMBL; LR812833; CAC8953929.1; -; Genomic_DNA. DR EMBL; LR812836; CAC8954013.1; -; Genomic_DNA. DR EMBL; LN999672; CUX91065.1; -; Genomic_DNA. DR EMBL; LN999677; CUX91070.1; -; Genomic_DNA. DR EMBL; LN999709; CUX91102.1; -; Genomic_DNA. DR EMBL; LN999710; CUX91103.1; -; Genomic_DNA. DR EMBL; LN999767; CUX91160.1; -; Genomic_DNA. DR EMBL; LN999771; CUX91164.1; -; Genomic_DNA. DR EMBL; MN889869; QHR76763.1; -; Genomic_DNA. DR EMBL; MT066118; QIB02187.1; -; Genomic_DNA. DR EMBL; MN461231; QJQ23414.1; -; Genomic_DNA. DR EMBL; MW605150; QSD59104.1; -; Genomic_DNA. DR EMBL; MZ292453; QWE90336.1; -; Genomic_DNA. DR EMBL; LT578429; SBO45770.1; -; Genomic_DNA. DR RefSeq; NP_002114.3; NM_002123.4. DR AlphaFoldDB; Q5Y7D6; -. DR SMR; Q5Y7D6; -. DR MassIVE; Q5Y7D6; -. DR MaxQB; Q5Y7D6; -. DR PeptideAtlas; Q5Y7D6; -. DR ProteomicsDB; 65859; -. DR Antibodypedia; 2668; 218 antibodies from 18 providers. DR DNASU; 3119; -. DR Ensembl; ENST00000399084; ENSP00000382034; ENSG00000179344. DR Ensembl; ENST00000434651; ENSP00000407332; ENSG00000179344. DR GeneID; 3119; -. DR MANE-Select; ENST00000434651.7; ENSP00000407332.2; NM_002123.5; NP_002114.3. DR UCSC; uc003obw.4; human. DR CTD; 3119; -. DR HGNC; HGNC:4944; HLA-DQB1. DR OpenTargets; ENSG00000179344; -. DR PharmGKB; PA35068; -. DR VEuPathDB; HostDB:ENSG00000179344; -. DR GeneTree; ENSGT00940000154723; -. DR HOGENOM; CLU_047501_13_1_1; -. DR TreeFam; TF336626; -. DR BioGRID-ORCS; 3119; 11 hits in 1060 CRISPR screens. DR ChiTaRS; HLA-DQB1; human. DR GenomeRNAi; 3119; -. DR Proteomes; UP000005640; Chromosome 6. DR Bgee; ENSG00000179344; Expressed in right lung and 189 other cell types or tissues. DR ExpressionAtlas; Q5Y7D6; baseline and differential. DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell. DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW. DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW. DR GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW. DR CDD; cd21001; IgC1_MHC_II_beta_HLA-DQ_I-A; 1. DR Gene3D; 2.60.40.10; Immunoglobulins; 1. DR InterPro; IPR007110; Ig-like_dom. DR InterPro; IPR036179; Ig-like_dom_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR003006; Ig/MHC_CS. DR InterPro; IPR003597; Ig_C1-set. DR InterPro; IPR011162; MHC_I/II-like_Ag-recog. DR InterPro; IPR014745; MHC_II_a/b_N. DR InterPro; IPR000353; MHC_II_b_N. DR PANTHER; PTHR19944:SF101; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DQ BETA 1 CHAIN; 1. DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1. DR Pfam; PF07654; C1-set; 1. DR Pfam; PF00969; MHC_II_beta; 1. DR SMART; SM00407; IGc1; 1. DR SMART; SM00921; MHC_II_beta; 1. DR SUPFAM; SSF48726; Immunoglobulin; 1. DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1. DR PROSITE; PS50835; IG_LIKE; 1. DR PROSITE; PS00290; IG_MHC; 1. PE 1: Evidence at protein level; KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130}; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Endosome {ECO:0000256|ARBA:ARBA00022753}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Immunity {ECO:0000256|ARBA:ARBA00022859}; KW Lysosome {ECO:0000256|ARBA:ARBA00023228}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW MHC II {ECO:0000256|ARBA:ARBA00023182}; KW Proteomics identification {ECO:0007829|MaxQB:Q5Y7D6, KW ECO:0007829|PeptideAtlas:Q5Y7D6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}. FT SIGNAL 1..30 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 31..261 FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5014587155" FT TRANSMEM 231..251 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 129..217 FT /note="Ig-like" FT /evidence="ECO:0000259|PROSITE:PS50835" SQ SEQUENCE 261 AA; 29791 MW; 955BF0E22AA4BD79 CRC64; MSWKKALRIP GDLRVATVTL MLAMLSSLLA EGRDSPEDFV FQFKGMCYFT NGTERVRLVT RYIYNREEYA RFDSDVGVYR AVTPQGRPDA EYWNSQKEVL EGTRAELDTV CRHNYEVAFR GILQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPGQIK VRWFRNDQEE TAGVVSTPLI RNGDWTFQIL VMLEMTPQRG DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGVGGFVL GLIFLGLGLI IRQRSQKGLL H //