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Protein
Submitted name:

HLA class II histocompatibility antigen, DQ beta 1 chain

Gene

HLA-DQB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processImmunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA class II histocompatibility antigen, DQ beta 1 chainImported
Submitted name:
MHC class II antigenImported
Submitted name:
cDNA, FLJ79232, highly similar to HLA class II histocompatibility antigen, DQB1*0602 beta chainImported
Gene namesi
Name:HLA-DQB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000179344.16
HGNCiHGNC:4944 HLA-DQB1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei231 – 251HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000179344
PharmGKBiPA35068

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_501431020631 – 261Sequence analysisAdd BLAST231

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSG00000179344

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000382034

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini129 – 217Ig-likeInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the MHC class II family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IWG3 Eukaryota
ENOG410YI0S LUCA
GeneTreeiENSGT00900000140849
HOVERGENiHBG012730
TreeFamiTF336626

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.320.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
IPR011162 MHC_I/II-like_Ag-recog
IPR014745 MHC_II_a/b_N
IPR000353 MHC_II_b_N
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
PF00969 MHC_II_beta, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD000328 MHC_II_b_N, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SM00921 MHC_II_beta, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
SSF54452 SSF54452, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS00290 IG_MHC, 1 hit

Sequencei

Sequence statusi: Complete.

Q5Y7D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWKKALRIP GDLRVATVTL MLAMLSSLLA EGRDSPEDFV FQFKGMCYFT
60 70 80 90 100
NGTERVRLVT RYIYNREEYA RFDSDVGVYR AVTPQGRPDA EYWNSQKEVL
110 120 130 140 150
EGTRAELDTV CRHNYEVAFR GILQRRVEPT VTISPSRTEA LNHHNLLVCS
160 170 180 190 200
VTDFYPGQIK VRWFRNDQEE TAGVVSTPLI RNGDWTFQIL VMLEMTPQRG
210 220 230 240 250
DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGVGGFVL GLIFLGLGLI
260
IRQRSQKGLL H
Length:261
Mass (Da):29,791
Last modified:May 10, 2005 - v1
Checksum:i955BF0E22AA4BD79
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662789 Genomic DNA No translation available.
AY663395 Genomic DNA Translation: AAU87980.1
AY663406 Genomic DNA Translation: AAU88009.1
AY663411 Genomic DNA Translation: AAU88024.1
KF270555 Genomic DNA Translation: AGW82949.2
MF417566 Genomic DNA Translation: AST16107.1
AK316333 mRNA Translation: BAH14704.1
AB774942 Genomic DNA Translation: BAN59788.1
AB774978 Genomic DNA Translation: BAN59824.1
LN999672 Genomic DNA Translation: CUX91065.1
LN999677 Genomic DNA Translation: CUX91070.1
LN999709 Genomic DNA Translation: CUX91102.1
LN999710 Genomic DNA Translation: CUX91103.1
LN999767 Genomic DNA Translation: CUX91160.1
LN999771 Genomic DNA Translation: CUX91164.1
LT578429 Genomic DNA Translation: SBO45770.1
RefSeqiNP_002114.3, NM_002123.4
UniGeneiHs.409934
Hs.534322

Genome annotation databases

EnsembliENST00000399084; ENSP00000382034; ENSG00000179344
ENST00000434651; ENSP00000407332; ENSG00000179344
GeneIDi3119
UCSCiuc003obw.4 human

Similar proteinsi

Entry informationi

Entry nameiQ5Y7D6_HUMAN
AccessioniPrimary (citable) accession number: Q5Y7D6
Entry historyiIntegrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: April 25, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health