ID   Q5Y7D1_HUMAN            Unreviewed;       266 AA.
AC   Q5Y7D1;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 171.
DE   SubName: Full=HLA class II histocompatibility antigen DR beta chain {ECO:0000313|EMBL:BBD34092.1};
DE   SubName: Full=HLA class II histocompatibility antigen, DRB1 beta chain {ECO:0000313|Ensembl:ENSP00000331343.7};
DE   SubName: Full=HLA-DRB1 protein {ECO:0000313|EMBL:BAO73159.1};
DE   SubName: Full=MHC class II antigen {ECO:0000313|EMBL:AAU88011.1};
DE   SubName: Full=Major histocompatibility complex, class II, DR beta 1 (Clone P2-beta-3) {ECO:0000313|EMBL:CAB06490.1};
GN   Name=HLA-DRB1 {ECO:0000313|EMBL:AAU88011.1,
GN   ECO:0000313|Ensembl:ENSP00000331343.7};
GN   ORFNames=RP1-93N13.1-001 {ECO:0000313|EMBL:CAB06490.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAU88011.1};
RN   [1] {ECO:0000313|Ensembl:ENSP00000331343.7}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=14574404; DOI=10.1038/nature02055;
RA   Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA   Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA   Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA   Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA   Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA   Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA   Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA   Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA   Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA   Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA   French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA   Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA   Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA   Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA   Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA   Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA   Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA   Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA   Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA   Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA   Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA   Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA   Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA   Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA   Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA   West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA   Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA   Bentley D.R., Coulson A., Durbin R., Hubbard T., Sulston J.E., Dunham I.,
RA   Rogers J., Beck S.;
RT   "The DNA sequence and analysis of human chromosome 6.";
RL   Nature 425:805-811(2003).
RN   [2] {ECO:0000313|EMBL:AAU88011.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=16140993; DOI=10.1101/gr.3554305;
RA   Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S.,
RA   Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V.;
RT   "Ancient haplotypes of the HLA Class II region.";
RL   Genome Res. 15:1250-1257(2005).
RN   [3] {ECO:0000313|EMBL:AAX63452.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=17174751; DOI=10.1016/j.humimm.2006.09.002;
RA   Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P.,
RA   de Pablo R., Garcia-Sanchez F., Vicario J.L.;
RT   "Group-specific amplification of cDNA from DRB1 genes. Complete coding
RT   sequences of partially defined alleles and identification of the new
RT   alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113.";
RL   Hum. Immunol. 67:1008-1016(2006).
RN   [4] {ECO:0000313|EMBL:CAB06490.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Williams S.;
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:ADI59556.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Zhu F.M., He Y.M., Yan L.X.;
RT   "Full length cDNA sequence of HLA-DRB1*03:01:01:01.";
RL   Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:ADI59556.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=21388356; DOI=10.1111/j.1399-0039.2010.01626.x;
RA   Zhu F., He Y., Tao S., Zhang W., He J., He J., Xu X., Lv H., Yan L.;
RT   "Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-
RT   specific amplification primers in the Chinese Han population.";
RL   Tissue Antigens 77:329-332(2011).
RN   [7] {ECO:0000313|EMBL:BAO73159.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=24355003; DOI=10.1111/tan.12258;
RA   Ozaki Y., Suzuki S., Shigenari A., Okudaira Y., Kikkawa E., Oka A., Ota M.,
RA   Mitsunaga S., Kulski J.K., Inoko H., Shiina T.;
RT   "HLA-DRB1, -DRB3, -DRB4 and -DRB5 genotyping at a super-high resolution
RT   level by long range PCR and high-throughput sequencing.";
RL   Tissue Antigens 83:10-16(2014).
RN   [8] {ECO:0000313|EMBL:CZQ50742.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [9] {ECO:0000313|EMBL:CZQ50742.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Marsh S.G.E.;
RT   "Full-length genomic HLA sequences.";
RL   Submitted (JUL-2017) to the EMBL/GenBank/DDBJ databases.
RN   [10] {ECO:0000313|EMBL:BBD34092.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=30337930; DOI=.3389/fimmu.2018.02294;
RA   Suzuki S., Ranade S., Osaki K., Ito S., Shigenari A., Ohnuki Y., Oka A.,
RA   Masuya A., Harting J., Baybayan P., Kitazume M., Sunaga J., Morishima S.,
RA   Morishima Y., Inoko H., Kulski J.K., Shiina T.;
RT   "Reference Grade Characterization of Polymorphisms in Full-Length HLA Class
RT   I and II Genes With Short-Read Sequencing on the ION PGM System and Long-
RT   Reads Generated by Single Molecule, Real-Time Sequencing on the PacBio
RT   Platform.";
RL   Front. Immunol. 9:2294-2294(2018).
RN   [11] {ECO:0000313|EMBL:CAD5895161.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Albrecht V., Schmidt H. A., Klussmeier A., Lange V., Putke K.;
RL   Submitted (SEP-2020) to the EMBL/GenBank/DDBJ databases.
RN   [12] {ECO:0007829|PDB:7N19}
RP   X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) OF 33-219, AND DISULFIDE BONDS.
RX   PubMed=34410304; DOI=10.1084/jem.20210785;
RA   Greaves S.A., Ravindran A., Santos R.G., Chen L., Falta M.T., Wang Y.,
RA   Mitchell A.M., Atif S.M., Mack D.G., Tinega A.N., Maier L.A., Dai S.,
RA   Pinilla C., Grunewald J., Fontenot A.P.;
RT   "CD4+ T cells in the lungs of acute sarcoidosis patients recognize an
RT   Aspergillus nidulans epitope.";
RL   J. Exp. Med. 218:e20210785-e20210785(2021).
RN   [13] {ECO:0000313|EMBL:CAE6990065.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Turner R T.;
RL   Submitted (JAN-2021) to the EMBL/GenBank/DDBJ databases.
RN   [14] {ECO:0000313|Ensembl:ENSP00000331343.7}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2022) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004530}. Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004352}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004352}.
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DR   EMBL; AL662842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL929581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AY663399; AAU87990.1; -; Genomic_DNA.
DR   EMBL; AY663407; AAU88011.1; -; Genomic_DNA.
DR   EMBL; AY961064; AAX63452.1; -; mRNA.
DR   EMBL; HM067844; ADI59556.1; -; mRNA.
DR   EMBL; AB829524; BAO73159.1; -; Genomic_DNA.
DR   EMBL; LC257774; BBD34092.1; -; Genomic_DNA.
DR   EMBL; Z84489; CAB06490.1; -; Genomic_DNA.
DR   EMBL; LR878369; CAD5127856.1; -; Genomic_DNA.
DR   EMBL; LR878371; CAD5127858.1; -; Genomic_DNA.
DR   EMBL; LR878373; CAD5127860.1; -; Genomic_DNA.
DR   EMBL; LR878374; CAD5127861.1; -; Genomic_DNA.
DR   EMBL; LR878398; CAD5127885.1; -; Genomic_DNA.
DR   EMBL; LR878422; CAD5127909.1; -; Genomic_DNA.
DR   EMBL; LR878423; CAD5127910.1; -; Genomic_DNA.
DR   EMBL; LR880420; CAD5137397.1; -; Genomic_DNA.
DR   EMBL; LR880421; CAD5137398.1; -; Genomic_DNA.
DR   EMBL; LR880441; CAD5137418.1; -; Genomic_DNA.
DR   EMBL; LR882675; CAD5895161.1; -; Genomic_DNA.
DR   EMBL; LR882676; CAD5895163.1; -; Genomic_DNA.
DR   EMBL; LR882677; CAD5895164.1; -; Genomic_DNA.
DR   EMBL; LR882678; CAD5895166.1; -; Genomic_DNA.
DR   EMBL; LR882737; CAD5895209.1; -; Genomic_DNA.
DR   EMBL; HG993069; CAE6990065.1; -; Genomic_DNA.
DR   EMBL; HG993070; CAE6990068.1; -; Genomic_DNA.
DR   EMBL; OU385940; CAG7912257.1; -; Genomic_DNA.
DR   EMBL; LT220256; CZQ50742.1; -; Genomic_DNA.
DR   RefSeq; NP_001230894.1; NM_001243965.1.
DR   PDB; 7N19; X-ray; 2.38 A; B/E/H/K=33-219.
DR   AlphaFoldDB; Q5Y7D1; -.
DR   SMR; Q5Y7D1; -.
DR   MassIVE; Q5Y7D1; -.
DR   DNASU; 3123; -.
DR   Ensembl; ENST00000328980.11; ENSP00000331343.7; ENSG00000206306.10.
DR   Ensembl; ENST00000399450.6; ENSP00000382378.2; ENSG00000206240.11.
DR   GeneID; 3123; -.
DR   KEGG; hsa:3123; -.
DR   UCSC; uc063uqs.1; human.
DR   CTD; 3123; -.
DR   HGNC; HGNC:4948; HLA-DRB1.
DR   OrthoDB; 3785866at2759; -.
DR   BioGRID-ORCS; 3123; 23 hits in 1057 CRISPR screens.
DR   ChiTaRS; HLA-DRB1; human.
DR   GenomeRNAi; 3123; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   GO; GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
DR   CDD; cd21000; IgC1_MHC_II_beta_HLA-DR; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003006; Ig/MHC_CS.
DR   InterPro; IPR003597; Ig_C1-set.
DR   InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR   InterPro; IPR014745; MHC_II_a/b_N.
DR   InterPro; IPR000353; MHC_II_b_N.
DR   PANTHER; PTHR19944:SF99; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DR BETA 3 CHAIN; 1.
DR   PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR   Pfam; PF07654; C1-set; 1.
DR   Pfam; PF00969; MHC_II_beta; 1.
DR   SMART; SM00407; IGc1; 1.
DR   SMART; SM00921; MHC_II_beta; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS00290; IG_MHC; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:7N19};
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   MHC II {ECO:0000256|ARBA:ARBA00023182};
KW   Proteomics identification {ECO:0007829|MaxQB:Q5Y7D1,
KW   ECO:0007829|PeptideAtlas:Q5Y7D1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           30..266
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014310211"
FT   TRANSMEM        228..250
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          126..214
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DISULFID        44..108
FT                   /evidence="ECO:0007829|PDB:7N19"
FT   DISULFID        146..202
FT                   /evidence="ECO:0007829|PDB:7N19"
SQ   SEQUENCE   266 AA;  30120 MW;  37329B097C6BEEB4 CRC64;
     MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT ERVRYLDRYF
     HNQEENVRFD SDVGEFRAVT ELGRPDAEYW NSQKDLLEQK RGRVDNYCRH NYGVVESFTV
     QRRVHPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG
     DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL
     FLGAGLFIYF RNQKGHSGLQ PRGFLS
//