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Protein
Submitted name:

HLA-DRB1 protein

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA-DRB1 proteinImported
Submitted name:
MHC class II antigenImported
Gene namesi
Name:HLA-DRB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. MHC class II protein complex Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IIUniRule annotationSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ5Y7D1.
SMRiQ5Y7D1. Positions 34-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOVERGENiHBG012730.
KOiK06752.
OMAiNGTERRY.
PhylomeDBiQ5Y7D1.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Y7D1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT
60 70 80 90 100
ERVRYLDRYF HNQEENVRFD SDVGEFRAVT ELGRPDAEYW NSQKDLLEQK
110 120 130 140 150
RGRVDNYCRH NYGVVESFTV QRRVHPKVTV YPSKTQPLQH HNLLVCSVSG
160 170 180 190 200
FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG DWTFQTLVML ETVPRSGEVY
210 220 230 240 250
TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF
260
RNQKGHSGLQ PRGFLS
Length:266
Mass (Da):30,120
Last modified:May 10, 2005 - v1
Checksum:i37329B097C6BEEB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663399 Genomic DNA. Translation: AAU87990.1.
AY663407 Genomic DNA. Translation: AAU88011.1.
AY961064 mRNA. Translation: AAX63452.1.
HM067844 mRNA. Translation: ADI59556.1.
AB829524 Genomic DNA. Translation: BAO73159.1.
RefSeqiNP_001230894.1. NM_001243965.1.
UniGeneiHs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

Genome annotation databases

GeneIDi3123.
KEGGihsa:3123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663399 Genomic DNA. Translation: AAU87990.1.
AY663407 Genomic DNA. Translation: AAU88011.1.
AY961064 mRNA. Translation: AAX63452.1.
HM067844 mRNA. Translation: ADI59556.1.
AB829524 Genomic DNA. Translation: BAO73159.1.
RefSeqiNP_001230894.1. NM_001243965.1.
UniGeneiHs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

3D structure databases

ProteinModelPortaliQ5Y7D1.
SMRiQ5Y7D1. Positions 34-220.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi3123.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3123.
KEGGihsa:3123.

Organism-specific databases

CTDi3123.
H-InvDBHIX0005754.
HIX0078596.

Phylogenomic databases

HOVERGENiHBG012730.
KOiK06752.
OMAiNGTERRY.
PhylomeDBiQ5Y7D1.

Miscellaneous databases

ChiTaRSiHLA-DRB1. human.
GenomeRNAii3123.
NextBioi12394.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113."
    Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P., de Pablo R., Garcia-Sanchez F., Vicario J.L.
    Hum. Immunol. 67:1008-1016(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Full length cDNA sequence of HLA-DRB1*03:01:01:01."
    Zhu F.M., He Y.M., Yan L.X.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population."
    Zhu F., He Y., Tao S., Zhang W., He J., He J., Xu X., Lv H., Yan L.
    Tissue Antigens 77:329-332(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "HLA-DRB1, -DRB3, -DRB4 and -DRB5 genotyping at a super-high resolution level by long range PCR and high-throughput sequencing."
    Ozaki Y., Suzuki S., Shigenari A., Okudaira Y., Kikkawa E., Oka A., Ota M., Mitsunaga S., Kulski J.K., Inoko H., Shiina T.
    Tissue Antigens 83:10-16(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ5Y7D1_HUMAN
AccessioniPrimary (citable) accession number: Q5Y7D1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: March 4, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.