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Q5Y7D1

- Q5Y7D1_HUMAN

UniProt

Q5Y7D1 - Q5Y7D1_HUMAN

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Protein
Submitted name: HLA-DRB1 protein
Gene
HLA-DRB1
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
  2. immune response Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA-DRB1 proteinImported
Submitted name:
MHC class II antigenImported
Gene namesi
Name:HLA-DRB1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. MHC class II protein complex Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IIUniRule annotationSAAS annotations

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Family & Domainsi

Sequence similaritiesi

Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotations

Keywords - Domaini

Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG012730.
KOiK06752.
OMAiNGMERVR.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view]
ProDomiPD000328. MHC_II_b_N. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Y7D1-1 [UniParc]FASTAAdd to Basket

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MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT    50
ERVRYLDRYF HNQEENVRFD SDVGEFRAVT ELGRPDAEYW NSQKDLLEQK 100
RGRVDNYCRH NYGVVESFTV QRRVHPKVTV YPSKTQPLQH HNLLVCSVSG 150
FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG DWTFQTLVML ETVPRSGEVY 200
TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF 250
RNQKGHSGLQ PRGFLS 266
Length:266
Mass (Da):30,120
Last modified:May 10, 2005 - v1
Checksum:i37329B097C6BEEB4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY663399 Genomic DNA. Translation: AAU87990.1.
AY663407 Genomic DNA. Translation: AAU88011.1.
AY961064 mRNA. Translation: AAX63452.1.
HM067844 mRNA. Translation: ADI59556.1.
AB829524 Genomic DNA. Translation: BAO73159.1.
RefSeqiNP_001230894.1. NM_001243965.1.
UniGeneiHs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

Genome annotation databases

GeneIDi3123.
KEGGihsa:3123.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY663399 Genomic DNA. Translation: AAU87990.1 .
AY663407 Genomic DNA. Translation: AAU88011.1 .
AY961064 mRNA. Translation: AAX63452.1 .
HM067844 mRNA. Translation: ADI59556.1 .
AB829524 Genomic DNA. Translation: BAO73159.1 .
RefSeqi NP_001230894.1. NM_001243965.1.
UniGenei Hs.534322.
Hs.696211.
Hs.716081.
Hs.723344.
Hs.736560.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

DNASUi 3123.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3123.
KEGGi hsa:3123.

Organism-specific databases

CTDi 3123.
H-InvDB HIX0005754.
HIX0078596.

Phylogenomic databases

HOVERGENi HBG012730.
KOi K06752.
OMAi NGMERVR.

Miscellaneous databases

ChiTaRSi HLA-DRB1. human.
GenomeRNAii 3123.
NextBioi 12394.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR000353. MHC_II_b_N.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00969. MHC_II_beta. 1 hit.
[Graphical view ]
ProDomi PD000328. MHC_II_b_N. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00407. IGc1. 1 hit.
SM00921. MHC_II_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113."
    Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P., de Pablo R., Garcia-Sanchez F., Vicario J.L.
    Hum. Immunol. 67:1008-1016(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Full length cDNA sequence of HLA-DRB1*03:01:01:01."
    Zhu F.M., He Y.M., Yan L.X.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population."
    Zhu F., He Y., Tao S., Zhang W., He J., He J., Xu X., Lv H., Yan L.
    Tissue Antigens 77:329-332(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "HLA-DRB1, -DRB3, -DRB4 and -DRB5 genotyping at a super-high resolution level by long range PCR and high-throughput sequencing."
    Ozaki Y., Suzuki S., Shigenari A., Okudaira Y., Kikkawa E., Oka A., Ota M., Mitsunaga S., Kulski J.K., Inoko H., Shiina T.
    Tissue Antigens 83:10-16(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ5Y7D1_HUMAN
AccessioniPrimary (citable) accession number: Q5Y7D1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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