Q5Y7D1 (Q5Y7D1_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
MHC class II antigen EMBL AAU88011.1

Gene names

Name:

HLA-DRB1 EMBL AAU88011.1

Organism

Homo sapiens (Human) EMBL AAU88011.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	266 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS003006

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC II SAAS SAAS003006 RuleBase RU000321 Membrane
Domain	Transmembrane Transmembrane helix SAAS SAAS014745
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class II protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q5Y7D1 [UniParc]. Last modified May 10, 2005. Version 1. Checksum: 37329B097C6BEEB4	FASTA	266	30,120
	10 20 30 40 50 60 MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT ERVRYLDRYF 70 80 90 100 110 120 HNQEENVRFD SDVGEFRAVT ELGRPDAEYW NSQKDLLEQK RGRVDNYCRH NYGVVESFTV 130 140 150 160 170 180 QRRVHPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG 190 200 210 220 230 240 DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL 250 260 FLGAGLFIYF RNQKGHSGLQ PRGFLS

References

[1]	"Ancient haplotypes of the HLA Class II region." Raymond C.K., Kas A., Paddock M., Qiu R., Zhou Y., Subramanian S., Chang J., Palmieri A., Haugen E., Kaul R., Olson M.V. Genome Res. 15:1250-1257(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113." Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P., de Pablo R., Garcia-Sanchez F., Vicario J.L. Hum. Immunol. 67:1008-1016(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Full length cDNA sequence of HLA-DRB1*03:01:01:01." Zhu F.M., He Y.M., Yan L.X. Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population." Zhu F., He Y., Tao S., Zhang W., He J., He J., Xu X., Lv H., Yan L. Tissue Antigens 77:329-332(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY663399 Genomic DNA. Translation: AAU87990.1. AY663407 Genomic DNA. Translation: AAU88011.1. AY961064 mRNA. Translation: AAX63452.1. HM067844 mRNA. Translation: ADI59556.1.
IPI	IPI00473139.
RefSeq	NP_001230894.1. NM_001243965.1.
UniGene	Hs.534322. Hs.696211. Hs.716081. Hs.723344. Hs.736560.
3D structure databases
ProteinModelPortal	Q5Y7D1.
ModBase	Search...
Proteomic databases
PRIDE	Q5Y7D1.
Protocols and materials databases
DNASU	3123.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3123.
KEGG	hsa:3123.
Organism-specific databases
CTD	3123.
H-InvDB	HIX0005754. HIX0078596.
Phylogenomic databases
HOVERGEN	HBG012730.
KO	K06752.
Gene expression databases
ArrayExpress	Q5Y7D1.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.10.320.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR000353. MHC_II_b_N. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00969. MHC_II_beta. 1 hit. [Graphical view]
ProDom	PD000328. MHC_II_b_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00407. IGc1. 1 hit. SM00921. MHC_II_beta. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-DRB1. human.
GenomeRNAi	3123.
NextBio	12394.

Entry information

Entry name

Q5Y7D1_HUMAN

Accession

Primary (citable) accession number: Q5Y7D1

Entry history

Integrated into UniProtKB/TrEMBL:	May 10, 2005
Last sequence update:	May 10, 2005
Last modified:	May 29, 2013
This is version 90 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.