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Q5Y7D1

- Q5Y7D1_HUMAN

UniProt

Q5Y7D1 - Q5Y7D1_HUMAN

Protein
Submitted name:

HLA-DRB1 protein

Gene

HLA-DRB1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (10 May 2005)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
    2. immune response Source: InterPro

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HLA-DRB1 proteinImported
    Submitted name:
    MHC class II antigenImported
    Gene namesi
    Name:HLA-DRB1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. MHC class II protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MHC IIUniRule annotationSAAS annotation

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Structurei

    3D structure databases

    SMRiQ5Y7D1. Positions 34-220.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG012730.
    KOiK06752.
    OMAiNGMERVR.
    PhylomeDBiQ5Y7D1.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view]
    ProDomiPD000328. MHC_II_b_N. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q5Y7D1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVCLRLPGGS CMAVLTVTLM VLSSPLALAG DTRPRFLEYS TSECHFFNGT    50
    ERVRYLDRYF HNQEENVRFD SDVGEFRAVT ELGRPDAEYW NSQKDLLEQK 100
    RGRVDNYCRH NYGVVESFTV QRRVHPKVTV YPSKTQPLQH HNLLVCSVSG 150
    FYPGSIEVRW FRNGQEEKTG VVSTGLIHNG DWTFQTLVML ETVPRSGEVY 200
    TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL FLGAGLFIYF 250
    RNQKGHSGLQ PRGFLS 266
    Length:266
    Mass (Da):30,120
    Last modified:May 10, 2005 - v1
    Checksum:i37329B097C6BEEB4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY663399 Genomic DNA. Translation: AAU87990.1.
    AY663407 Genomic DNA. Translation: AAU88011.1.
    AY961064 mRNA. Translation: AAX63452.1.
    HM067844 mRNA. Translation: ADI59556.1.
    AB829524 Genomic DNA. Translation: BAO73159.1.
    RefSeqiNP_001230894.1. NM_001243965.1.
    UniGeneiHs.534322.
    Hs.696211.
    Hs.716081.
    Hs.723344.
    Hs.736560.

    Genome annotation databases

    GeneIDi3123.
    KEGGihsa:3123.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY663399 Genomic DNA. Translation: AAU87990.1 .
    AY663407 Genomic DNA. Translation: AAU88011.1 .
    AY961064 mRNA. Translation: AAX63452.1 .
    HM067844 mRNA. Translation: ADI59556.1 .
    AB829524 Genomic DNA. Translation: BAO73159.1 .
    RefSeqi NP_001230894.1. NM_001243965.1.
    UniGenei Hs.534322.
    Hs.696211.
    Hs.716081.
    Hs.723344.
    Hs.736560.

    3D structure databases

    SMRi Q5Y7D1. Positions 34-220.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 3123.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3123.
    KEGGi hsa:3123.

    Organism-specific databases

    CTDi 3123.
    H-InvDB HIX0005754.
    HIX0078596.

    Phylogenomic databases

    HOVERGENi HBG012730.
    KOi K06752.
    OMAi NGMERVR.
    PhylomeDBi Q5Y7D1.

    Miscellaneous databases

    ChiTaRSi HLA-DRB1. human.
    GenomeRNAii 3123.
    NextBioi 12394.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.10.320.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR014745. MHC_II_a/b_N.
    IPR000353. MHC_II_b_N.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00969. MHC_II_beta. 1 hit.
    [Graphical view ]
    ProDomi PD000328. MHC_II_b_N. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00407. IGc1. 1 hit.
    SM00921. MHC_II_beta. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. "Group-specific amplification of cDNA from DRB1 genes. Complete coding sequences of partially defined alleles and identification of the new alleles DRB1*040602, DRB1*111102, DRB1*080103, and DRB1*0113."
      Balas A., Vilches C., Rodriguez M.A., Fernandez B., Martinez M.P., de Pablo R., Garcia-Sanchez F., Vicario J.L.
      Hum. Immunol. 67:1008-1016(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Full length cDNA sequence of HLA-DRB1*03:01:01:01."
      Zhu F.M., He Y.M., Yan L.X.
      Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "Analysis of the complete cDNA sequences of HLA-DRB1 alleles with group-specific amplification primers in the Chinese Han population."
      Zhu F., He Y., Tao S., Zhang W., He J., He J., Xu X., Lv H., Yan L.
      Tissue Antigens 77:329-332(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    5. "HLA-DRB1, -DRB3, -DRB4 and -DRB5 genotyping at a super-high resolution level by long range PCR and high-throughput sequencing."
      Ozaki Y., Suzuki S., Shigenari A., Okudaira Y., Kikkawa E., Oka A., Ota M., Mitsunaga S., Kulski J.K., Inoko H., Shiina T.
      Tissue Antigens 83:10-16(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ5Y7D1_HUMAN
    AccessioniPrimary (citable) accession number: Q5Y7D1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.