UniProtKB - Q5Y7C6 (Q5Y7C6_HUMAN)
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Protein
Submitted name:
MHC class II antigen
Gene
HLA-DQA1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
- immune response Source: InterPro
Keywordsi
Biological process | Immunity |
Names & Taxonomyi
Protein namesi | Submitted name: MHC class II antigenImported |
Gene namesi | Name:HLA-DQA1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 221 – 239 | HelicalSequence analysisAdd BLAST | 19 |
Keywords - Cellular componenti
Membrane, MHC IISAAS annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5010140920 | 24 – 254 | Sequence analysisAdd BLAST | 231 |
Keywords - PTMi
Disulfide bondSAAS annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 192 | Ig-likeInterPro annotationAdd BLAST | 81 |
Sequence similaritiesi
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotationPhylogenomic databases
HOVERGENi | HBG006862. |
Family and domain databases
Gene3Di | 2.60.40.10. 1 hit. 3.10.320.10. 1 hit. |
InterProi | View protein in InterPro IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig-like_fold. IPR003006. Ig/MHC_CS. IPR003597. Ig_C1-set. IPR011162. MHC_I/II-like_Ag-recog. IPR014745. MHC_II_a/b_N. IPR001003. MHC_II_a_N. |
Pfami | View protein in Pfam PF07654. C1-set. 1 hit. PF00993. MHC_II_alpha. 1 hit. |
SMARTi | View protein in SMART SM00407. IGc1. 1 hit. SM00920. MHC_II_alpha. 1 hit. |
SUPFAMi | SSF48726. SSF48726. 1 hit. SSF54452. SSF54452. 1 hit. |
PROSITEi | View protein in PROSITE PS50835. IG_LIKE. 1 hit. PS00290. IG_MHC. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q5Y7C6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILNKALMLG TLALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH
60 70 80 90 100
EFDGDEQFYV DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK
110 120 130 140 150
RSNSTAATNE VPEVTVFSKS PVTLGQPNIL ICLVDNIFPP VVNITWLSNG
160 170 180 190 200
HSVTEGVSET SFLSKSDHSF FKISYLTLLP SAEESYDCKV EHWGLDKPLL
210 220 230 240 250
KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR GLRSVGASRH
QGPL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY663394 Genomic DNA. Translation: AAU87975.1. AY663409 Genomic DNA. Translation: AAU88016.1. AY663412 Genomic DNA. Translation: AAU88025.1. KU319358 Genomic DNA. Translation: ANG08773.1. KU319359 Genomic DNA. Translation: ANG08774.1. KU319360 Genomic DNA. Translation: ANG08775.1. KU319361 Genomic DNA. Translation: ANG08776.1. KU319362 Genomic DNA. Translation: ANG08777.1. HE966411 Genomic DNA. Translation: CCJ51907.1. LN885090 Genomic DNA. Translation: CUQ94671.1. |
UniGenei | Hs.387679. Hs.591798. Hs.706240. |
Similar proteinsi
Entry informationi
Entry namei | Q5Y7C6_HUMAN | |
Accessioni | Q5Y7C6Primary (citable) accession number: Q5Y7C6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 23, 2004 |
Last sequence update: | November 23, 2004 | |
Last modified: | February 28, 2018 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |