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Protein
Submitted name:

MHC class II antigen

Gene

HLA-DQA1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class II antigenImported
Gene namesi
Name:HLA-DQA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei221 – 239HelicalSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC IISAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500792523224 – 254Sequence analysisAdd BLAST231

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PeptideAtlasiQ5Y7C6.
PRIDEiQ5Y7C6.

Interactioni

Protein-protein interaction databases

MINTiMINT-1373026.

Structurei

3D structure databases

ProteinModelPortaliQ5Y7C6.
SMRiQ5Y7C6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 192Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST81

Sequence similaritiesi

Belongs to the MHC class II family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

HOVERGENiHBG006862.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q5Y7C6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILNKALMLG TLALTTVMSP CGGEDIVADH VASYGVNLYQ SYGPSGQYTH
60 70 80 90 100
EFDGDEQFYV DLGRKETVWC LPVLRQFRFD PQFALTNIAV LKHNLNSLIK
110 120 130 140 150
RSNSTAATNE VPEVTVFSKS PVTLGQPNIL ICLVDNIFPP VVNITWLSNG
160 170 180 190 200
HSVTEGVSET SFLSKSDHSF FKISYLTLLP SAEESYDCKV EHWGLDKPLL
210 220 230 240 250
KHWEPEIPAP MSELTETVVC ALGLSVGLVG IVVGTVFIIR GLRSVGASRH

QGPL
Length:254
Mass (Da):27,835
Last modified:November 23, 2004 - v1
Checksum:i84E12B5C5A480A8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663394 Genomic DNA. Translation: AAU87975.1.
AY663409 Genomic DNA. Translation: AAU88016.1.
AY663412 Genomic DNA. Translation: AAU88025.1.
KU319358 Genomic DNA. Translation: ANG08773.1.
KU319359 Genomic DNA. Translation: ANG08774.1.
KU319360 Genomic DNA. Translation: ANG08775.1.
KU319361 Genomic DNA. Translation: ANG08776.1.
KU319362 Genomic DNA. Translation: ANG08777.1.
HE966411 Genomic DNA. Translation: CCJ51907.1.
LN885090 Genomic DNA. Translation: CUQ94671.1.
UniGeneiHs.387679.
Hs.591798.
Hs.706240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663394 Genomic DNA. Translation: AAU87975.1.
AY663409 Genomic DNA. Translation: AAU88016.1.
AY663412 Genomic DNA. Translation: AAU88025.1.
KU319358 Genomic DNA. Translation: ANG08773.1.
KU319359 Genomic DNA. Translation: ANG08774.1.
KU319360 Genomic DNA. Translation: ANG08775.1.
KU319361 Genomic DNA. Translation: ANG08776.1.
KU319362 Genomic DNA. Translation: ANG08777.1.
HE966411 Genomic DNA. Translation: CCJ51907.1.
LN885090 Genomic DNA. Translation: CUQ94671.1.
UniGeneiHs.387679.
Hs.591798.
Hs.706240.

3D structure databases

ProteinModelPortaliQ5Y7C6.
SMRiQ5Y7C6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1373026.

Proteomic databases

PeptideAtlasiQ5Y7C6.
PRIDEiQ5Y7C6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006862.

Miscellaneous databases

ChiTaRSiHLA-DQA1. human.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.10.320.10. 1 hit.
InterProiIPR032431. C1-set_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011162. MHC_I/II-like_Ag-recog.
IPR014745. MHC_II_a/b_N.
IPR001003. MHC_II_a_N.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF16196. C1-set_C. 1 hit.
PF00993. MHC_II_alpha. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
SM00920. MHC_II_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ5Y7C6_HUMAN
AccessioniPrimary (citable) accession number: Q5Y7C6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: November 30, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.